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Baseline and changes in serum uric acid independently predict 11-year incidence of metabolic syndrome among community-dwelling women

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Abstract

Introduction

Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. In women, increased serum uric acid (SUA) levels are associated with MetS and its components. However, whether baseline and changes in SUA predict incidence of MetS and its components remains unclear.

Methods

The subjects comprised 407 women aged 71 ± 8 years from a rural village. We have identified participants who underwent a similar examination 11 years ago, and examined the relationship between baseline and changes in SUA, and MetS based on the modified criteria of the National Cholesterol Education Program’s Adult Treatment Panel (NCEP-ATP) III report.

Results

Of these subjects, 83 (20.4%) women at baseline and 190 (46.7%) women at follow-up had MetS. Multiple linear regression analysis was performed to evaluate the contribution of each confounding factor for MetS; both baseline and changes in SUA as well as history of cardiovascular disease, low-density lipoprotein cholesterol, and estimated glomerular filtration ratio (eGFR) were independently and significantly associated with the number of MetS components during an 11-year follow-up. The adjusted odds ratios (ORs) (95% confidence interval) for incident MetS across tertiles of baseline SUA and changes in SUA were 1.00, 1.47 (0.82–2.65), and 3.11 (1.66–5.83), and 1.00, 1.88 (1.03–3.40), and 2.49 (1.38–4.47), respectively. In addition, the combined effect between increased baseline and changes in SUA was also a significant and independent determinant for the accumulation of MetS components (F = 20.29, p < 0.001). The ORs for incident MetS were significant only in subjects with age ≥ 55 years, decline in eGFR, and no baseline MetS.

Conclusions

These results suggested that combined assessment of baseline and changes in SUA levels provides increased information for incident MetS, independent of other confounding factors in community-dwelling women.

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Acknowledgements

This work was supported in part by a grant-in-aid from the Foundation for Development of Community (2017). No additional external funding was received for this study. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Authors and Affiliations

  1. Department of Community Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon-city, Ehime, 791-0295, Japan

    R. Kawamoto, D. Ninomiya, K. Senzaki & T. Kumagi

  2. Department of Internal Medicine, Seiyo Municipal Nomura Hospital, 9-53 Nomura, Nomura-cho, Seiyo-city, Ehime, 797-1212, Japan

    R. Kawamoto, D. Ninomiya, Y. Kasai, K. Senzaki, T. Kusunoki & N. Ohtsuka

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  1. R. Kawamoto
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Correspondence to R. Kawamoto.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee at which the studies were conducted (IRB Approval number: 1402009).

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Kawamoto, R., Ninomiya, D., Kasai, Y. et al. Baseline and changes in serum uric acid independently predict 11-year incidence of metabolic syndrome among community-dwelling women. J Endocrinol Invest 41, 959–968 (2018). https://doi.org/10.1007/s40618-017-0822-8

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  • DOI: https://doi.org/10.1007/s40618-017-0822-8

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