References
Upadhyay A, Jaber BL, Madias NE (2006) Incidence and prevalence of hyponatremia. Am J Med 119(7 Suppl 1):S30–S35
Adrogue HJ, Madias NE (2000) Hyponatremia. N Engl J Med 342(21):1581–1589
Gill G, Huda B, Boyd A, Skagen K, Wile D, Watson I et al (2006) Characteristics and mortality of severe hyponatraemia—a hospital-based study. Clin Endocrinol (Oxf) 65(2):246–249
Renneboog B, Musch W, Vandemergel X, Manto MU, Decaux G (2006) Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med. 119(1):71e1–71e8
Gankam Kengne F, Andres C, Sattar L, Melot C, Decaux G (2008) Mild hyponatremia and risk of fracture in the ambulatory elderly. QJM 101(7):583–588
Kinsella S, Moran S, Sullivan MO, Molloy MG, Eustace JA (2010) Hyponatremia independent of osteoporosis is associated with fracture occurrence. Clin J Am Soc Nephrol 5(2):275–280
Verbalis JG, Barsony J, Sugimura Y, Tian Y, Adams DJ, Carter EA et al (2010) Hyponatremia-induced osteoporosis. J Bone Miner Res 25(3):554–563
Barsony J, Sugimura Y, Verbalis JG (2011) Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss. J Biol Chem 286(12):10864–10875
Corona G, Giuliani C, Parenti G, Norello D, Verbalis JG, Forti G et al (2013) Moderate hyponatremia is associated with increased risk of mortality: evidence from a meta-analysis. PLoS One 8(12):e80451
Corona G, Giuliani C, Parenti G, Colombo GL, Sforza A, Maggi M et al (2016) The economic burden of hyponatremia: systematic review and meta-analysis. Am J Med. 129(8):823e4–835e4
Chambrey R, Trepiccione F (2015) Relative roles of principal and intercalated cells in the regulation of sodium balance and blood pressure. Curr Hypertens Rep 17(4):538
Cuesta M, Garrahy A, Thompson CJ (2016) SIAD: practical recommendations for diagnosis and management. J Endocrinol Invest 39(9):991–1001
Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D et al (2014) Clinical practice guideline on diagnosis and treatment of hyponatraemia. Intensive Care Med 40(3):320–331
Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH et al (2013) Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations. Am J Med 126(10 Suppl 1):S1–S42
Hoorn EJ, Lindemans J, Zietse R (2006) Development of severe hyponatraemia in hospitalized patients: treatment-related risk factors and inadequate management. Nephrol Dial Transplant 21(1):70–76
Rondon-Berrios H, Berl T (2016) Vasopressin receptor antagonists: characteristics and clinical role. Best Pract Res Clin Endocrinol Metab 30(2):289–303
Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D et al (2014) Clinical practice guideline on diagnosis and treatment of hyponatraemia. Nephrol Dial Transplant 29(Suppl 2):i1–i39
Regolisti G, Cabassi A, Antonucci E, Brusasco I, Cademartiri C, Pistolesi V et al (2015) Hyponatremia in clinical practice. G Ital Nefrol 32(1)
Aylwin S, Burst V, Peri A, Runkle I, Thatcher N (2015) ‘Dos and don’ts’ in the management of hyponatremia. Curr Med Res Opin 31(9):1755–1761
Glover DJ, Glick JH (1987) Metabolic oncologic emergencies. CA Cancer J Clin 37(5):302–320
Silverman P, Distelhorst CW (1989) Metabolic emergencies in clinical oncology. Semin Oncol 16(6):504–515
Berghmans T, Paesmans M, Body JJ (2000) A prospective study on hyponatraemia in medical cancer patients: epidemiology, aetiology and differential diagnosis. Support Care Cancer 8(3):192–197
Liamis G, Milionis H, Elisaf M (2008) A review of drug-induced hyponatremia. Am J Kidney Dis 52(1):144–153
Doshi SM, Shah P, Lei X, Lahoti A, Salahudeen AK (2012) Hyponatremia in hospitalized cancer patients and its impact on clinical outcomes. Am J Kidney Dis 59(2):222–228
Sterns RH, Silver SM, Hix JK (2015) Urea for hyponatremia? Kidney Int 87(2):268–270
Decaux G, Unger J, Brimioulle S, Mockel J (1982) Hyponatremia in the syndrome of inappropriate secretion of antidiuretic hormone. Rapid correction with urea, sodium chloride, and water restriction therapy. JAMA 247(4):471–474
Decaux G, Andres C, Gankam Kengne F, Soupart A (2010) Treatment of euvolemic hyponatremia in the intensive care unit by urea. Crit Care 14(5):R184
Soupart A, Coffernils M, Couturier B, Gankam-Kengne F, Decaux G (2012) Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH. Clin J Am Soc Nephrol 7(5):742–747
Petereit C, Zaba O, Teber I, Luders H, Grohe C (2013) A rapid and efficient way to manage hyponatremia in patients with SIADH and small cell lung cancer: treatment with tolvaptan. BMC Pulm Med 13:55
Verbalis JG (2010) Managing hyponatremia in patients with syndrome of inappropriate antidiuretic hormone secretion. Endocrinol Nutr 57(Suppl 2):30–40
Berardi R, Caramanti M, Castagnani M, Guglielmi S, Marcucci F, Savini A et al (2015) Hyponatremia is a predictor of hospital length and cost of stay and outcome in cancer patients. Support Care Cancer 23(10):3095–3101
Berl T (2013) An elderly patient with chronic hyponatremia. Clin J Am Soc Nephrol 8(3):469–475
Mannesse CK, Vondeling AM, van Marum RJ, van Solinge WW, Egberts TC, Jansen PA (2013) Prevalence of hyponatremia on geriatric wards compared to other settings over four decades: a systematic review. Ageing Res Rev 12(1):165–173
Soiza RL, Cumming K, Clarke JM, Wood KM, Myint PK (2014) Hyponatremia: special considerations in older patients. J Clin Med 3(3):944–958
Shapiro DS, Sonnenblick M, Galperin I, Melkonyan L, Munter G (2010) Severe hyponatraemia in elderly hospitalized patients: prevalence, aetiology and outcome. Intern Med J 40(8):574–580
Beck LH (1998) Changes in renal function with aging. Clin Geriatr Med 14(2):199–209
Lindeman RD, Tobin J, Shock NW (1985) Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc 33(4):278–285
Moran D, Fronk C, Mandel E (2014) Managing hyponatremia in adults. JAAPA 27(4):23–29 (quiz 30)
Kugler JP, Hustead T (2000) Hyponatremia and hypernatremia in the elderly. Am Fam Physician 61(12):3623–3630
Wannamethee SG, Shaper AG, Lennon L, Papacosta O, Whincup P (2016) Mild hyponatremia, hypernatremia and incident cardiovascular disease and mortality in older men: a population-based cohort study. Nutr Metab Cardiovasc Dis 26(1):12–19
Hoyle GE, Chua M, Soiza RL (2011) Volaemic assessment of the elderly hyponatraemic patient: reliability of clinical assessment and validation of bioelectrical impedance analysis. QJM 104(1):35–39
De Luca L, Klein L, Udelson JE, Orlandi C, Sardella G, Fedele F et al (2005) Hyponatremia in patients with heart failure. Am J Cardiol 96(12A):19L–23L
Gheorghiade M, Abraham WT, Albert NM, Gattis Stough W, Greenberg BH, O’Connor CM et al (2007) Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry. Eur Heart J 28(8):980–988
Friedewald VE, Emmett M, Gheorghiade M, Roberts WC (2011) The editor’s roundtable: pathophysiology and management of hyponatremia and the role of vasopressin antagonists. Am J Cardiol 107(9):1357–1364
Farmakis D, Filippatos G, Parissis J, Kremastinos DT, Gheorghiade M (2009) Hyponatremia in heart failure. Heart Fail Rev 14(2):59–63
Gheorghiade M, Rossi JS, Cotts W, Shin DD, Hellkamp AS, Pina IL et al (2007) Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE Trial. Arch Intern Med 167(18):1998–2005
Wald R, Jaber BL, Price LL, Upadhyay A, Madias NE (2010) Impact of hospital-associated hyponatremia on selected outcomes. Arch Intern Med 170(3):294–302
Urso C, Brucculeri S, Caimi G (2015) Acid-base and electrolyte abnormalities in heart failure: pathophysiology and implications. Heart Fail Rev 20(4):493–503
Bettari L, Fiuzat M, Shaw LK, Wojdyla DM, Metra M, Felker GM et al (2012) Hyponatremia and long-term outcomes in chronic heart failure—an observational study from the Duke Databank for Cardiovascular Diseases. J Card Fail. 18(1):74–81
Konishi M, Haraguchi G, Ohigashi H, Sasaoka T, Yoshikawa S, Inagaki H et al (2012) Progression of hyponatremia is associated with increased cardiac mortality in patients hospitalized for acute decompensated heart failure. J Card Fail. 18(8):620–625
De Vecchis R, Di Maio M, Di Biase G, Ariano C (2016) Effects of hyponatremia normalization on the short-term mortality and rehospitalizations in patients with recent acute decompensated heart failure: a retrospective study. J Clin Med 5(10):92
Konstam MA, Gheorghiade M, Burnett JC Jr, Grinfeld L, Maggioni AP, Swedberg K et al (2007) Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial. JAMA 297(12):1319–1331
Rossi J, Bayram M, Udelson JE, Lloyd-Jones D, Adams KF, Oconnor CM et al (2007) Improvement in hyponatremia during hospitalization for worsening heart failure is associated with improved outcomes: insights from the Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Chronic Heart Failure (ACTIV in CHF) trial. Acute Card Care 9(2):82–86
Hauptman PJ, Burnett J, Gheorghiade M, Grinfeld L, Konstam MA, Kostic D et al (2013) Clinical course of patients with hyponatremia and decompensated systolic heart failure and the effect of vasopressin receptor antagonism with tolvaptan. J Card Fail 19(6):390–397
Schrier RW, Gross P, Gheorghiade M, Berl T, Verbalis JG, Czerwiec FS et al (2006) Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med 355(20):2099–2112
Felker GM, Mentz RJ, Adams KF, Cole RT, Egnaczyk GF, Patel CB et al (2015) Tolvaptan in patients hospitalized with acute heart failure: rationale and design of the TACTICS and the SECRET of CHF Trials. Circ Heart Fail 8(5):997–1005
Angeli P, Wong F, Watson H, Gines P, Investigators C (2006) Hyponatremia in cirrhosis: results of a patient population survey. Hepatology 44(6):1535–1542
Gines P, Berl T, Bernardi M, Bichet DG, Hamon G, Jimenez W et al (1998) Hyponatremia in cirrhosis: from pathogenesis to treatment. Hepatology 28(3):851–864
Gines P, Guevara M (2008) Hyponatremia in cirrhosis: pathogenesis, clinical significance, and management. Hepatology 48(3):1002–1010
Fukui H (2015) Do vasopressin V2 receptor antagonists benefit cirrhotics with refractory ascites? World J Gastroenterol 21(41):11584–11596
Kim WR, Biggins SW, Kremers WK, Wiesner RH, Kamath PS, Benson JT et al (2008) Hyponatremia and mortality among patients on the liver-transplant waiting list. N Engl J Med 359(10):1018–1026
Guyader D, Patat A, Ellis-Grosse EJ, Orczyk GP (2002) Pharmacodynamic effects of a nonpeptide antidiuretic hormone V2 antagonist in cirrhotic patients with ascites. Hepatology 36(5):1197–1205
Gines P, Wong F, Watson H, Terg R, Bruha R, Zarski JP et al (2010) Clinical trial: short-term effects of combination of satavaptan, a selective vasopressin V2 receptor antagonist, and diuretics on ascites in patients with cirrhosis without hyponatraemia—a randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther 31(8):834–845
Wong F, Gines P, Watson H, Horsmans Y, Angeli P, Gow P et al (2010) Effects of a selective vasopressin V2 receptor antagonist, satavaptan, on ascites recurrence after paracentesis in patients with cirrhosis. J Hepatol 53(2):283–290
Wong F, Watson H, Gerbes A, Vilstrup H, Badalamenti S, Bernardi M et al (2012) Satavaptan for the management of ascites in cirrhosis: efficacy and safety across the spectrum of ascites severity. Gut 61(1):108–116
Gerbes AL, Gulberg V, Gines P, Decaux G, Gross P, Gandjini H et al (2003) Therapy of hyponatremia in cirrhosis with a vasopressin receptor antagonist: a randomized double-blind multicenter trial. Gastroenterology 124(4):933–939
Okita K, Kawazoe S, Hasebe C, Kajimura K, Kaneko A, Okada M et al (2014) Dose-finding trial of tolvaptan in liver cirrhosis patients with hepatic edema: a randomized, double-blind, placebo-controlled trial. Hepatol Res. 44(1):83–91
Sakaida I, Kawazoe S, Kajimura K, Saito T, Okuse C, Takaguchi K et al (2014) Tolvaptan for improvement of hepatic edema: a phase 3, multicenter, randomized, double-blind, placebo-controlled trial. Hepatol Res 44(1):73–82
Watkins PB, Lewis JH, Kaplowitz N, Alpers DH, Blais JD, Smotzer DM et al (2015) Clinical pattern of tolvaptan-associated liver injury in subjects with autosomal dominant polycystic kidney disease: analysis of clinical trials database. Drug Saf 38(11):1103–1113
Kovesdy CP, Lott EH, Lu JL, Malakauskas SM, Ma JZ, Molnar MZ et al (2012) Hyponatremia, hypernatremia, and mortality in patients with chronic kidney disease with and without congestive heart failure. Circulation 125(5):677–684
Dimitriadis C, Sekercioglu N, Pipili C, Oreopoulos D, Bargman JM (2014) Hyponatremia in peritoneal dialysis: epidemiology in a single center and correlation with clinical and biochemical parameters. Perit Dial Int 34(3):260–270
Khan S, Floris M, Pani A, Rosner MH (2016) Sodium and volume disorders in advanced chronic kidney disease. Adv Chronic Kidney Dis 23(4):240–246
Negro A, Regolisti G, Perazzoli F, Davoli S, Sani C, Rossi E (1998) Ifosfamide-induced renal Fanconi syndrome with associated nephrogenic diabetes insipidus in an adult patient. Nephrol Dial Transplant 13(6):1547–1549
Combs S, Berl T (2014) Dysnatremias in patients with kidney disease. Am J Kidney Dis 63(2):294–303
Waikar SS, Curhan GC, Brunelli SM (2011) Mortality associated with low serum sodium concentration in maintenance hemodialysis. Am J Med 124(1):77–84
Nigwekar SU, Wenger J, Thadhani R, Bhan I (2013) Hyponatremia, mineral metabolism, and mortality in incident maintenance hemodialysis patients: a cohort study. Am J Kidney Dis 62(4):755–762
Hecking M, Karaboyas A, Saran R, Sen A, Inaba M, Rayner H et al (2012) Dialysate sodium concentration and the association with interdialytic weight gain, hospitalization, and mortality. Clin J Am Soc Nephrol 7(1):92–100
Tanaka A, Katsuno T, Ozaki T, Sakata F, Kato N, Suzuki Y et al (2015) The efficacy of tolvaptan as a diuretic for chronic kidney disease patients. Acta Cardiol 70(2):217–223
Dangoisse C, Dickie H, Tovey L, Ostermann M (2014) Correction of hyper- and hyponatraemia during continuous renal replacement therapy. Nephron Clin Pract 128(3–4):394–398
Wendland EM, Kaplan AA (2012) A proposed approach to the dialysis prescription in severely hyponatremic patients with end-stage renal disease. Semin Dial 25(1):82–85
Ball SG, Iqbal Z (2016) Diagnosis and treatment of hyponatraemia. Best Pract Res Clin Endocrinol Metab 30(2):161–173
Gisby M, Lundberg J, Landin M, O’Reilly K, Robinson P, Sobocki P et al (2016) The burden of illness in patients with hyponatraemia in Sweden: a population-based registry study. Int J Clin Pract 70(4):319–329
Rodrigues B, Staff I, Fortunato G, McCullough LD (2014) Hyponatremia in the prognosis of acute ischemic stroke. J Stroke Cerebrovasc Dis 23(5):850–854
Hiew FL, Winer JB, Rajabally YA (2016) Hyponatraemia in Guillain–Barre syndrome revisited. Acta Neurol Scand 133(4):295–301
Holland-Bill L, Christiansen CF, Heide-Jorgensen U, Ulrichsen SP, Ring T, Jorgensen JO et al (2015) Hyponatremia and mortality risk: a Danish cohort study of 279 508 acutely hospitalized patients. Eur J Endocrinol 173(1):71–81
Sherlock M, O’Sullivan E, Agha A, Behan LA, Owens D, Finucane F et al (1002) Incidence and pathophysiology of severe hyponatraemia in neurosurgical patients. Postgrad Med J 2009(85):171–175
Mapa B, Taylor BE, Appelboom G, Bruce EM, Claassen J, Connolly ES Jr (2016) Impact of hyponatremia on morbidity, mortality, and complications after aneurysmal subarachnoid hemorrhage: a systematic review. World Neurosurg 85:305–314
Kelly DF, Laws ER Jr, Fossett D (1995) Delayed hyponatremia after transsphenoidal surgery for pituitary adenoma. Report of nine cases. J Neurosurg 83(2):363–367
Kristof RA, Rother M, Neuloh G, Klingmuller D (2009) Incidence, clinical manifestations, and course of water and electrolyte metabolism disturbances following transsphenoidal pituitary adenoma surgery: a prospective observational study. J Neurosurg 111(3):555–562
Olson BR, Rubino D, Gumowski J, Oldfield EH (1995) Isolated hyponatremia after transsphenoidal pituitary surgery. J Clin Endocrinol Metab 80(1):85–91
Bales J, Cho S, Tran TK, Korab GA, Khandelwal N, Spiekerman CF et al (2016) The effect of hyponatremia and sodium variability on outcomes in adults with aneurysmal subarachnoid hemorrhage. World Neurosurg 96:340–349
Williams C, Simon TD, Riva-Cambrin J, Bratton SL (2012) Hyponatremia with intracranial malignant tumor resection in children. J Neurosurg Pediatr 9(5):524–529
Kao L, Al-Lawati Z, Vavao J, Steinberg GK, Katznelson L (2009) Prevalence and clinical demographics of cerebral salt wasting in patients with aneurysmal subarachnoid hemorrhage. Pituitary 12(4):347–351
Palmer BF (2003) Hyponatremia in patients with central nervous system disease: SIADH versus CSW. Trends Endocrinol Metab 14(4):182–187
Loh JA, Verbalis JG (2007) Diabetes insipidus as a complication after pituitary surgery. Nat Clin Pract Endocrinol Metab 3(6):489–494
Zhang L, Fu P, Wang L, Cai G, Zhang L, Chen D et al (2013) Hyponatraemia in patients with crush syndrome during the Wenchuan earthquake. Emerg Med J. 30(9):745–748
Roquilly A, Mahe PJ, Seguin P, Guitton C, Floch H, Tellier AC et al (2011) Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study. JAMA 305(12):1201–1209
Aqil A, Hossain F, Sheikh H, Aderinto J, Whitwell G, Kapoor H (2016) Achieving hip fracture surgery within 36 hours: an investigation of risk factors to surgical delay and recommendations for practice. J Orthop Traumatol 17(3):207–213
Sharif S, Dominguez M, Imbriano L, Mattana J, Maesaka JK (2015) Recognition of hyponatremia as a risk factor for hip fractures in older persons. J Am Geriatr Soc 63(9):1962–1964
Murthy K, Koshkina O, Marcantonio AJ, Pala N, Breeze JL, Paulus J et al (2015) Hyponatremia and fracture risk: a hospital-based case–control study. J Am Geriatr Soc 63(8):1699–1701
Usala RL, Fernandez SJ, Mete M, Cowen L, Shara NM, Barsony J et al (2015) hyponatremia is associated with increased osteoporosis and bone fractures in a large US health system population. J Clin Endocrinol Metab 100(8):3021–3031
Hawkins RC (2003) Age and gender as risk factors for hyponatremia and hypernatremia. Clin Chim Acta 337(1–2):169–172
Tasdemir V, Oguz AK, Sayin I, Ergun I (2015) Hyponatremia in the outpatient setting: clinical characteristics, risk factors, and outcome. Int Urol Nephrol 47(12):1977–1983
Liamis G, Rodenburg EM, Hofman A, Zietse R, Stricker BH, Hoorn EJ (2013) Electrolyte disorders in community subjects: prevalence and risk factors. Am J Med 126(3):256–263
Gankam-Kengne F, Ayers C, Khera A, de Lemos J, Maalouf NM (2013) Mild hyponatremia is associated with an increased risk of death in an ambulatory setting. Kidney Int 83(4):700–706
Liamis G, Filippatos TD, Elisaf MS (2016) Thiazide-associated hyponatremia in the elderly: what the clinician needs to know. J Geriatr Cardiol 13(2):175–182
Sajadieh A, Binici Z, Mouridsen MR, Nielsen OW, Hansen JF, Haugaard SB (2009) Mild hyponatremia carries a poor prognosis in community subjects. Am J Med 122(7):679–686
Hoorn EJ, Rivadeneira F, van Meurs JB, Ziere G, Stricker BH, Hofman A et al (2011) Mild hyponatremia as a risk factor for fractures: the Rotterdam study. J Bone Miner Res 26(8):1822–1828
Verbalis JG, Adler S, Schrier RW, Berl T, Zhao Q, Czerwiec FS et al (2011) Efficacy and safety of oral tolvaptan therapy in patients with the syndrome of inappropriate antidiuretic hormone secretion. Eur J Endocrinol 164(5):725–732
De las Penas R, Ponce S, Henao F, Camps Herrero C, Carcereny E, Escobar Alvarez Y et al (2016) SIADH-related hyponatremia in hospital day care units: clinical experience and management with tolvaptan. Support Care Cancer. 24(1):499–507
Almond CS, Shin AY, Fortescue EB, Mannix RC, Wypij D, Binstadt BA et al (2005) Hyponatremia among runners in the Boston Marathon. N Engl J Med 352(15):1550–1556
Ben-Abraham R, Szold O, Rudick V, Weinbroum AA (2003) ‘Ecstasy’ intoxication: life-threatening manifestations and resuscitative measures in the intensive care setting. Eur J Emerg Med 10(4):309–313
Arieff AI (1984) Central nervous system manifestations of disordered sodium metabolism. Clin Endocrinol Metab 13(2):269–294
Berl T (1990) Treating hyponatremia: what is all the controversy about? Ann Intern Med 113(6):417–419
Edelman IS, Leibman J, O’Meara MP, Birkenfeld LW (1958) Interrelations between serum sodium concentration, serum osmolarity and total exchangeable sodium, total exchangeable potassium and total body water. J Clin Invest 37(9):1236–1256
Sterns RH, Hix JK, Silver S (2010) Treating profound hyponatremia: a strategy for controlled correction. Am J Kidney Dis 56(4):774–779
Hanna RM, Yang WT, Lopez EA, Riad JN, Wilson J (2016) The utility and accuracy of four equations in predicting sodium levels in dysnatremic patients. Clin Kidney J 9(4):530–539
Trepiccione F, Capasso G, Lippi G (2014) Serum and urine osmolality: clinical and laboratory features. G Ital Nefrol 31(5)
Corona G, Giuliani C, Verbalis JG, Forti G, Maggi M, Peri A (2015) Hyponatremia improvement is associated with a reduced risk of mortality: evidence from a meta-analysis. PLoS One 10(4):e0124105
Ellison DH, Berl T (2007) Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med 356(20):2064–2072
Grohe C, Berardi R, Burst V (2015) Hyponatraemia–SIADH in lung cancer diagnostic and treatment algorithms. Crit Rev Oncol Hematol 96(1):1–8
Onitilo AA, Kio E, Doi SA (2007) Tumor-related hyponatremia. Clin Med Res 5(4):228–237
Berardi R, Rinaldi S, Caramanti M, Grohe C, Santoni M, Morgese F et al (2016) Hyponatremia in cancer patients: time for a new approach. Crit Rev Oncol Hematol 102:15–25
Berardi R, Santoni M, Rinaldi S, Nunzi E, Smerilli A, Caramanti M et al (2016) Risk of hyponatraemia in cancer patients treated with targeted therapies: a systematic review and meta-analysis of clinical trials. PLoS One 11(5):e0152079
Illouz F, Braun D, Briet C, Schweizer U, Rodien P (2014) Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors. Eur J Endocrinol 171(3):R91–R99
Lu X, Wang X (2017) Hyponatremia induced by antiepileptic drugs in patients with epilepsy. Expert Opin Drug Saf 16(1):77–87
Tsapepas D, Chiles M, Babayev R, Rao MK, Jaitly M, Salerno D et al (2016) Incidence of hyponatremia with high-dose trimethoprim-sulfamethoxazole exposure. Am J Med 129(12):1322–1328
Tanaka R, Suzuki Y, Takumi Y, Iwao M, Sato Y, Hashinaga K et al (2016) A retrospective analysis of risk factors for linezolid-associated hyponatremia in Japanese patients. Biol Pharm Bull 39(12):1968–1973
Spital A (1999) Diuretic-induced hyponatremia. Am J Nephrol 19(4):447–452
Gandhi S, Shariff SZ, Al-Jaishi A, Reiss JP, Mamdani MM, Hackam DG et al (2017) Second-generation antidepressants and hyponatremia risk: a population-based cohort study of older adults. Am J Kidney Dis 69(1):87–96
Buon M, Gaillard C, Martin J, Fedrizzi S, Mosquet B, Coquerel A et al (2013) Risk of proton pump inhibitor-induced mild hyponatremia in older adults. J Am Geriatr Soc 61(11):2052–2054
Izzedine H, Fardet L, Launay-Vacher V, Dorent R, Petitclerc T, Deray G (2002) Angiotensin-converting enzyme inhibitor-induced syndrome of inappropriate secretion of antidiuretic hormone: case report and review of the literature. Clin Pharmacol Ther 71(6):503–507
Yamada H, Asano T, Aoki A, Ikoma A, Yoshida M, Kusaka I et al (2014) Combination therapy of angiotensin II receptor blocker and thiazide produces severe hyponatremia in elderly hypertensive subjects. Intern Med 53(7):749–752
Acknowledgements
We would like to thank all the members of the Fluid and Electrolyte Disorders Club of the Italian Society of Endocrinology, for the scientific support during the writing of the manuscript.
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A.M.I. has been an occasional consultant for Shire and Novartis; R.B. has been an occasional consultant for Otsuka; G.M. has been an occasional consultant for Shire and Novartis; A.L. has been an occasional consultant for Shire and Novartis; A.P. has been an occasional consultant for Otsuka. All other authors have nothing to disclose.
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Sbardella, E., Isidori, A.M., Arnaldi, G. et al. Approach to hyponatremia according to the clinical setting: Consensus statement from the Italian Society of Endocrinology (SIE), Italian Society of Nephrology (SIN), and Italian Association of Medical Oncology (AIOM). J Endocrinol Invest 41, 3–19 (2018). https://doi.org/10.1007/s40618-017-0776-x
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DOI: https://doi.org/10.1007/s40618-017-0776-x