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Longitudinal changes of trabecular bone score after estrogen deprivation: effect of menopause and aromatase inhibition

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Abstract

Purpose

To examine the effects of the menopausal transition and treatment with aromatase inhibitors (AI) on trabecular bone score (TBS, a newly proposed index of bone architecture derived from DXA vertebral scans) and vertebral bone mineral density (BMD).

Methods

Retrospective cohort study on 29 women who became postmenopausal during a mean follow-up of 2.9 years (MP group) and 34 women treated with AI during a mean follow-up of 2.1 years (AI group). BMD was measured by DXA and TBS with a specific software.

Results

TBS decreased after menopause, but the change was significantly lower than that of the lumbar BMD (−4.6 vs. −6.8 %; mean difference: 2.2 %; p = 0.016). An even larger difference was observed in the AI group (−2.1 vs. −5.9 %; mean difference: 3.8 %; p = 0.002).

Conclusions

The decrease of TBS induced by menopause or treatment with AI is significantly lower than that of lumbar BMD.

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Conflict of interest

Mario Pedrazzoni, Alessia Casola, Ignazio Verzicco, Barbara Abbate, Rosanna Vescovini and Paolo Sansoni declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, University of Parma, Via Gramsci, 14, 43126, Parma, Italy

    M. Pedrazzoni, A. Casola, I. Verzicco, B. Abbate, R. Vescovini & P. Sansoni

Authors
  1. M. Pedrazzoni
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  2. A. Casola
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  3. I. Verzicco
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  4. B. Abbate
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  5. R. Vescovini
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  6. P. Sansoni
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Corresponding author

Correspondence to M. Pedrazzoni.

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Pedrazzoni, M., Casola, A., Verzicco, I. et al. Longitudinal changes of trabecular bone score after estrogen deprivation: effect of menopause and aromatase inhibition. J Endocrinol Invest 37, 871–874 (2014). https://doi.org/10.1007/s40618-014-0125-2

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  • DOI: https://doi.org/10.1007/s40618-014-0125-2

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