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Cognitive and vascular function in older adults with and without CKD

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Abstract

Background

Cognitive impairment is a common complication of aging that is also associated with chronic kidney disease (CKD). Vascular dysfunction has been implicated as a potential cause of cognitive impairment in older adults, with particular deficits noted in those with CKD.

Aims

To determine the differences in cognitive function and vascular compliance in older adults with and without CKD with preclinical cognitive impairment and the relationship between these factors.

Methods

Utilizing a cross-sectional approach, 48 older adults with preclinical cognitive impairment (24 with and 24 without CKD) were evaluated for performance on a test of global cognition and executive function, and vascular compliance via tonometry and ultrasound.

Results

Cognitive function and some indicators of vascular function were significantly different in older adults with and without CKD. Global cognition was correlated with carotid-femoral pulse wave velocity (r = − 0.36, p = 0.02) in the entire sample. Vascular function was not correlated with executive function.

Discussion

Older adults with preclinical cognitive impairment and CKD had different cognitive and vascular function than those without CKD, and an indicator of vascular function may have a relationship with cognitive function in older adults.

Conclusions

The findings of this study support the assessment of cognitive and vascular function in older adults with and without CKD with preclinical cognitive impairment.

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Acknowledgments

Dr. Hannan is a Robert Wood Johnson Foundation Future of Nursing Scholar Postdoctoral Fellow. The views expressed here do not necessarily reflect the views of the Foundation. Dr. Hannan is a T32 Postdoctoral Fellow. Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number T32HL134634. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funding

This study was supported by a Grant made available by the American Nephrology Nurses Association (ANNA). Findings of the study do not necessarily reflect the opinions of ANNA. The views expressed herein are those of the author and no official endorsement by ANNA is intended or should be inferred. Dr. Bronas and the parent study were supported by NIH-NIA AG022849-15S1 and NIH-NIA AG022849. The project described was supported by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR002003. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Authors and Affiliations

  1. College of Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Mary Hannan

  2. College of Nursing, Department of Biobehavioral Health Science (M/C 802), University of Illinois at Chicago, 845 S Damen Avenue, Chicago, IL, 60612, USA

    Eileen G. Collins, Lauretta Quinn & Ulf G. Bronas

  3. College of Applied Health Sciences, Department of Physical Therapy, University of Illinois at Chicago, Chicago, IL, USA

    Shane A. Phillips

  4. College of Nursing, Department of Health Systems Science, University of Illinois at Chicago, Chicago, IL, USA

    Alana Steffen

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  6. Ulf G. Bronas
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Contributions

Conceptualization: MH, EGC, SAP, LQ, AS, and UGB; methodology: MH, EGC, SAP, LQ, AS, and UGB; formal analysis and investigation: MH; writing—original draft preparation: MH; writing—review and editing: MH, EGC, SAP, LQ, AS, and UGB; funding acquisition: MH and UGB; resources: MH, SAP and UGB; supervision: MH, EGC, SAP, LQ, AS, and UGB.

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Correspondence to Ulf G. Bronas.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was Granted by the Internal Review Board of the University of Illinois at Chicago (7/11/2018/#2018-0641).

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Hannan, M., Collins, E.G., Phillips, S.A. et al. Cognitive and vascular function in older adults with and without CKD. Aging Clin Exp Res 33, 1885–1894 (2021). https://doi.org/10.1007/s40520-020-01695-w

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