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Laparoscopic sleeve gastrectomy for morbid obesity and Klinefelter syndrome: clinical report on two patients, with long-term follow-up

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Abstract

Introduction

Klinefelter syndrome (KS) can appear as a wide spectrum of clinical manifestations, with no guidelines for appropriate treatment. We present the first study of bariatric surgery (BS) with a 48-month follow-up, for the management of two patients affected by obesity and KS.

Cases presentation

The first patient was a 32-year-old man with diagnosis of Klinefelter mosaicism (46 XY/47, XXY), Body Mass Index (BMI) of 50 kg/m2, metabolic syndrome and Binge Eating Disorder (BED). He underwent a Laparoscopic Sleeve Gastrectomy (LSG) with weight loss (BMI = 38 kg/m2) and improvements to his metabolic profile at 48 months. The second patient was a 44-year-old man with KS (47, XXY), BMI of 49 kg/m2, Obstructive Sleep Apnea Syndrome and BED. He underwent a banded LSG. After 48 months, he showed a satisfactory weight loss (BMI = 32 kg/m2) and amelioration of comorbidities.

Conclusion

In patients with KS, LSG demonstrated long-term beneficial effects for weight loss and amelioration of comorbidities. An interdisciplinary approach is mandatory, since it leads to adherence to follow-up programs and mental health well-being.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Chair of Psychiatry, Department of Systems Medicine, University of “Tor Vergata”, Via Montpellier 1, 00133, Rome, Italy

    Emanuela Bianciardi, Cinzia Niolu & Alberto Siracusano

  2. Department of Surgery, Obesity Unit, University of Rome “Tor Vergata”, Rome, Italy

    Paolo Orsaria & Paolo Gentileschi

Authors
  1. Emanuela Bianciardi
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  2. Paolo Orsaria
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  3. Cinzia Niolu
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  4. Alberto Siracusano
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  5. Paolo Gentileschi
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Contributions

PG was responsible for the conceptualization of this manuscript. EB and PG evaluated the two patients; PG performed the surgical procedures; EB, PO and PG wrote the manuscript, EB, PG, CN and AS reviewed the manuscript.

Corresponding author

Correspondence to Emanuela Bianciardi.

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Conflict of interest

The authors declare no conflict of interests.

Ethical approval

The study was approved by the Institutional Ethic Review Committee of the University of Rome “Tor Vergata”.

Informed consent

Both patients were informed and agreed with their case reports.

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The article is part of the Topical Collection on Obesity Surgery and Eating and Weight Disorders.

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Bianciardi, E., Orsaria, P., Niolu, C. et al. Laparoscopic sleeve gastrectomy for morbid obesity and Klinefelter syndrome: clinical report on two patients, with long-term follow-up. Eat Weight Disord 26, 1685–1690 (2021). https://doi.org/10.1007/s40519-020-00951-2

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  • DOI: https://doi.org/10.1007/s40519-020-00951-2

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