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Effect of hypovolemia on efficacy of reflex maintenance of blood pressure on orthostatic challenge

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Abstract

Introduction

Blood volume is an important determinant of the efficacy of the negative feedback mechanisms that maintain blood pressure. However, its effect on time profile and magnitude of the responses remain unstudied.

Aim

To study the effect of mild hypovolemia on time profiles and magnitude of changes in blood pressure and heart rate in healthy subjects before and after blood donation.

Methods

Fifty six healthy volunteer donors who signed up for blood donation were recruited (age 35 ± 7 years; weight 75 ± 9 Kg). Baseline beat to beat blood pressure and Lead II ECG was recorded for 5 min followed by orthostatic challenge for 3 min before and after blood donation.

Results

The donation of 450 ml of blood did not lead to any changes in the resting systolic, diastolic or mean blood pressure. However, there was a significant decrease in pulse pressure after blood donation along with an increase in the heart rate. During orthostatic challenge, after blood donation there was a greater fall in systolic, diastolic, mean and pulse pressure along with a greater increase in heart rate as compared to before the blood donation. The latency to response and the total time to recovery of blood pressure and heart rate increased significantly after blood donation.

Conclusion

Maintenance of blood pressure after orthostatic challenge is not compromised after mild hypovolemia produced by donation of 450 ml of blood. However, mild hypovolemia results in increase in latency of response and is accompanied with larger magnitude of fall in blood pressure during orthostatic challenge.

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Authors and Affiliations

  1. Department of Physiology, All India Institute of Medical Sciences, Room no. 2009, Teaching block, Second floor, Ansari Nagar, New Delhi, India

    Kavita Yadav,  Akanksha, Ashok Kumar Jaryal & K. K. Deepak

  2. Transfusion Medicine (Blood Bank), All India Institute of Medical Sciences, New Delhi, India

    Poonam Coshic & Kabita Chatterjee

Authors
  1. Kavita Yadav
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  2. Akanksha
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  3. Ashok Kumar Jaryal
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  4. Poonam Coshic
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  5. Kabita Chatterjee
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  6. K. K. Deepak
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Corresponding author

Correspondence to Ashok Kumar Jaryal.

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Authors declare no conflict of interest.

Ethical approval

The study protocol was approved by Institute Ethics Committee, All India Institute of Medical Sciences, New Delhi. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all subjects.

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Yadav, K., Akanksha, Jaryal, A.K. et al. Effect of hypovolemia on efficacy of reflex maintenance of blood pressure on orthostatic challenge. High Blood Press Cardiovasc Prev 23, 25–30 (2016). https://doi.org/10.1007/s40292-016-0130-y

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  • DOI: https://doi.org/10.1007/s40292-016-0130-y

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