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MicroRNAs Function in Dental Stem Cells as a Promising Biomarker and Therapeutic Target for Dental Diseases

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Abstract

Undifferentiated, highly proliferative, clonogenic, and self-renewing dental stem cells have paved the way for novel approaches to mending cleft palates, rebuilding lost jawbone and periodontal tissue, and, most significantly, recreating lost teeth. New treatment techniques may be guided by a better understanding of these cells and their potential in terms of the specificity of the regenerative response. MicroRNAs have been recognized as an essential component in stem cell biology due to their role as epigenetic regulators of the processes that determine stem cell destiny. MicroRNAs have been proven to be crucial in a wide variety of molecular and biological processes, including apoptosis, cell proliferation, migration, and necrocytosis. MicroRNAs have been recognized to control protein translation, messenger RNA stability, and transcription and have been reported to play essential roles in dental stem cell biology, including the differentiation of dental stem cells, the immunological response, apoptosis, and the inflammation of the dental pulp. Because microRNAs increase dental stem cell differentiation, they may be used in regenerative medicine to either preserve the stem cell phenotype or to aid in the development of tooth tissue. The development of novel biomarkers and therapies for dental illnesses relies heavily on progress made in our knowledge of the roles played by microRNAs in regulating dental stem cells. In this article, we discuss how dental stem cells and their associated microRNAs may be used to cure dental illness.

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Acknowledgements

The authors thank all researchers who contributed to the advancement of science.

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Authors and Affiliations

  1. Department of Dentistry, Islamic Azad University, Tehran, Iran

    Kamyar Nasiri

  2. Dental Research Center, School of Dentistry, Shahid Beheshti, Research Institute of Dental Sciences, University of Medical Sciences, Tehran, Iran

    Mohammad Jahri

  3. Shahid Sadoughi University of Medical Science, Yazd, Iran

    Shirin Kolahdouz

  4. Orthodontist, Private Practice, Tehran, Iran

    Milad Soleimani

  5. Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Science, Mashhad, Iran

    Ali Makiya

  6. COAMS, King Khalid University, Abha, 62529, Kingdom of Saudi Arabia

    Ravinder S. Saini

  7. Prosthetic Dental Techniques Department, Al-Mustaqbal University College, Babylon, 51001, Iraq

    Muna S. Merza

  8. Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran

    Saman Yasamineh

  9. Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Morteza Banakar

  10. Department of Pediatric Dentistry, Faculty of Dentistry, Shahed University, Tehran, Iran

    Morteza Banakar

  11. Student Research Committee, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

    Mohammad Hossein Yazdanpanah

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  1. Kamyar Nasiri
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Corresponding authors

Correspondence to Morteza Banakar or Mohammad Hossein Yazdanpanah.

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Kamyar Nasiri, Mohammad Jahri, Shirin Kolahdouz, Milad Soleimani, Ali Makiya, Ravinder S. Saini, Muna S. Merza, Saman Yasamineh, Morteza Banakar, and Mohammad Hossein Yazdanpanah have no conflicts of interest that are directly relevant to the content of this article.

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SY was responsible for the writing (original draft). KN, MJ, SK, MS, AM, RS, and MM reviewed and edited the article. All authors, including MB and MY, participated in the critical review process of the manuscript and approved the final version.

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Nasiri, K., Jahri, M., Kolahdouz, S. et al. MicroRNAs Function in Dental Stem Cells as a Promising Biomarker and Therapeutic Target for Dental Diseases. Mol Diagn Ther 27, 703–722 (2023). https://doi.org/10.1007/s40291-023-00675-w

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