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Ascorbic acid: still controversial when used against cancer resistance?

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Abstract

Ascorbic acid is known to be a strong antioxidant that exerts pro-oxidative effects at high concentrations and/or dosages. Therefore, it can be used as a protective agent and as an adjuvant or direct cytotoxic agent. Cancer cell resistance is a well-known issue, which encourages scientists to search for ways to fight it. The use of ascorbic acid against cancer resistance remains controversial. This paper outlines the potential use of ascorbic acid in cancer resistance, especially resistance due to chemotherapy and radiotherapy. Although it is hoped that this vitamin is useful in this setting, more research is needed.

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Authors and Affiliations

  1. Department of Pharmacy, Southern University Bangladesh, Mehedibag, Chittagong, 4000, Bangladesh

    Muhammad Torequl Islam

  2. Postgraduate Program in Pharmaceutical Science, Federal University of Piaui, Teresina, Piaui, 64.049-550, Brazil

    Muhammad Torequl Islam

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  1. Muhammad Torequl Islam
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Correspondence to Muhammad Torequl Islam.

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Muhammad Torequl Islam has no conflicts of interest that are directly relevant to the content of this manuscript.

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Islam, M.T. Ascorbic acid: still controversial when used against cancer resistance?. Drugs Ther Perspect 34, 81–84 (2018). https://doi.org/10.1007/s40267-017-0475-x

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