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Management of Older Adults with Mantle Cell Lymphoma

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Abstract

Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma that is largely a disease of older adults with a median age at diagnosis of 67 years. MCL is considered incurable with current therapies and has historically been associated with a poor prognosis. A subset of patients will present with features of more indolent disease and can be safely observed for a period of time after diagnosis, but the majority will require treatment at some point in the disease course. Younger patients who are eligible to undergo intensive induction chemotherapy followed by consolidation with an autologous stem cell transplant can experience prolonged survival times with a median overall survival of 13 years; however, there are limited data to support this treatment approach in older adults and these patients often have medical comorbidities that preclude such intensive therapy. Fortunately, an increased understanding of the disease biology has led to the development of novel therapies in recent years that are well-tolerated and have led to improved outcomes in this patient population. In this article, we will review the current treatment landscape for older adults with MCL, with a focus on the safety and efficacy of chemotherapy regimens and novel agents such as lenalidomide, bortezomib, and the Bruton’s tyrosine kinase inhibitors that have been formally studied in this population.

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  1. Department of Hematology and Medical Oncology, Winship Cancer Institute At Emory University, 1365C Clifton Road, NE, Suite B4000D, Atlanta, GA, 30322, USA

    Jason T. Romancik & Jonathon B. Cohen

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Jason T. Romancik performed the literature review and wrote the manuscript. Jonathon B. Cohen contributed to conception and design of the article and critically revised the work.

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Jonathon B. Cohen reports grant funding from the Lymphoma Research Foundation, and receipt of consulting fees from Loxo, Aptitude, Seattle Genetics, Gilead, Astra Zeneca, and Cellectar. Jason T Romancik declares that he has no conflicts of interest that might be relevant to the contents of this manuscript.

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Romancik, J.T., Cohen, J.B. Management of Older Adults with Mantle Cell Lymphoma. Drugs Aging 37, 469–481 (2020). https://doi.org/10.1007/s40266-020-00765-y

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