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Clinical Efficacy and Safety of Cilostazol: A Critical Review of the Literature

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Abstract

Cilostazol is a unique antiplatelet agent that has been commercially available for over two decades. As a phosphodiesterase III inhibitor, it reversibly inhibits platelet aggregation yet also possesses vasodilatory and antiproliferative properties. It has been widely studied in a variety of disease states, including peripheral arterial disease, cerebrovascular disease, and coronary artery disease with percutaneous coronary intervention. Overall, cilostazol appears to be a promising agent in the management of these disease states with a bleeding profile comparable to placebo; even when combined with other antiplatelet agents, cilostazol does not appear to increase the rate of bleeding. Despite the possible benefit of cilostazol, its use is limited by tolerability as some patients often report drug discontinuation due to headache, diarrhea, dizziness, or increased heart rate. To date, it has been predominantly studied in the Asian population, making it difficult to extrapolate these results to a more diverse patient population. This paper discusses the evolving role of cilostazol in the treatment of vascular diseases.

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Acknowledgments

No external funding was used for the preparation of this review article. None of the authors have any potential conflicts of interest that might be relevant to the content of this review article.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, University of Tennessee College of Pharmacy, 881 Madison Ave, Rm 457, Memphis, TN, 38163, USA

    Kelly C. Rogers & Shannon W. Finks

  2. Methodist University Hospital, Memphis, TN, USA

    Carrie S. Oliphant

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  1. Kelly C. Rogers
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  2. Carrie S. Oliphant
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  3. Shannon W. Finks
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Correspondence to Kelly C. Rogers.

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Rogers, K.C., Oliphant, C.S. & Finks, S.W. Clinical Efficacy and Safety of Cilostazol: A Critical Review of the Literature. Drugs 75, 377–395 (2015). https://doi.org/10.1007/s40265-015-0364-3

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  • DOI: https://doi.org/10.1007/s40265-015-0364-3

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