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Intracameral Cefuroxime

Prophylaxis of Postoperative Endophthalmitis after Cataract Surgery

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Abstract

Results of the landmark European Society of Cataract and Refractive Surgeons trial and additional prospective and retrospective studies support the use of intracameral cefuroxime in the prophylaxis of endophthalmitis following cataract surgery. Prophylaxis with intracameral cefuroxime at the recommended dose appears to be well tolerated in patients undergoing cataract surgery. However, off-label use of intracameral cefuroxime usually requires a two-step dilution process with the potential for dilution errors, and there are also concerns regarding the risk of contamination. Aprokam® (intracameral cefuroxime) has been approved in the EU for the prophylaxis of postoperative endophthalmitis after cataract surgery. After reconstitution of Aprokam®, no further dilution is required and each vial is only indicated for single-patient use; this has the potential to reduce the risk of both dilution errors and contamination.

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Disclosure

The preparation of this review was not supported by any external funding. During the peer review process, the manufacturer of the agent under review was also offered an opportunity to comment on this article. Changes resulting from comments received were made by the author on the basis of scientific and editorial merit.

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  1. Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand

    Gillian M. Keating

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  1. Gillian M. Keating
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Correspondence to Gillian M. Keating.

Additional information

The manuscript was reviewed by: P. Barry, Royal Victoria Eye & Ear and St Vincent’s University Hospitals, Dublin, Ireland; M. Lundström, Department of Clinical Sciences, Ophthalmology, Faculty of Medicine, Lund University, Sweden.

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Keating, G.M. Intracameral Cefuroxime. Drugs 73, 179–186 (2013). https://doi.org/10.1007/s40265-013-0011-9

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