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Self-assembled Supramolecular Artificial Transmembrane Ion Channels: Recent Progress and Application

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Chemical Research in Chinese Universities Aims and scope

Abstract

Natural protein channels have evolved with fantastic spatial structures, which play pivotal physiological functions in all living systems. Learning from nature, chemical scientists have developed a myriad of artificial transmembrane ion channels by using various chemical strategies, among which the non-covalent supramolecular ion channels exhibit remarkable advantages over other forms(e.g., single-molecule ion channel), which exhibited facile preparation methods, easier structural modification and functionalization. In this review, we have systematically summarized the recent progress of supramolecular self-assembled artificial transmembrane ion channels, which were classified by different self-assembly mechanisms, such as hydrogen bonds, π-π interactions, etc. Detailed preparation process and self-assembly strategies of the supramolecular ion channels have been described. Moreover, potential biomedical applications of the supramolecular ion channels have also been carefully discussed in this review. Finally, future opportunities and challenges facing this field were also elaborately discussed. It is anticipated that this review could provide a panoramic sketch and future directions towards the construction of novel artificial ion channels with novel functions and biomedical applications.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos.22161142015, 22105056).

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Authors and Affiliations

  1. College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Key Laboratory of Organosilicon Material Technology, Hangzhou Normal University, Hangzhou, 311121, P. R. China

    Yichen Luo, Canhong Zhu, Tianlong Zhang, Tengfei Yan & Junqiu Liu

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  1. Yichen Luo
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  2. Canhong Zhu
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  3. Tianlong Zhang
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  4. Tengfei Yan
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  5. Junqiu Liu
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Correspondence to Tengfei Yan or Junqiu Liu.

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Luo, Y., Zhu, C., Zhang, T. et al. Self-assembled Supramolecular Artificial Transmembrane Ion Channels: Recent Progress and Application. Chem. Res. Chin. Univ. 39, 3–12 (2023). https://doi.org/10.1007/s40242-023-2337-5

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  • DOI: https://doi.org/10.1007/s40242-023-2337-5

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