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An Efficient Method for Sulfonylation of Amines, Alcohols and Phenols with N-Fluorobenzenesulfonimide Under Mild Conditions

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Abstract

A new and convenient procedure was developed for the preparation of sulfonamides and sulfonic esters using N-fluorobenzenesulfonimide(NFSI) as a novel phenylsulfonyl group transfer reagent. In this protocol, a broad range of functional groups were tolerated to give the corresponding sulfonamides or sulfonic esters in moderate to excellent yields. The synthetic strategy for sulfonamides formation proceeded efficiently even under base-, metal- and additive-free conditions with the advantages of operational simplicity, mild reaction conditions as well as short reac-tion time.

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Authors and Affiliations

  1. Key Laboratory of Drug-targeting of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P. R. China

    Li Jing, Xinling Yu, Xiaohua Wu, Qiantao Wang & Yong Wu

  2. West China Hospital, Sichuan University, Chengdu, 610041, P. R. China

    Mei Guan

Authors
  1. Li Jing
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  2. Xinling Yu
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  3. Mei Guan
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  4. Xiaohua Wu
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  5. Qiantao Wang
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  6. Yong Wu
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Corresponding authors

Correspondence to Qiantao Wang or Yong Wu.

Additional information

Supported by the National Natural Science Foundation of China(Nos.81373259, 81573286).

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40242_2018_7305_MOESM1_ESM.pdf

An Efficient Method for Sulfonylation of Amines, Alcohols and Phenols with N-Fluorobenzenesulfonimide Under Mild Conditions

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Jing, L., Yu, X., Guan, M. et al. An Efficient Method for Sulfonylation of Amines, Alcohols and Phenols with N-Fluorobenzenesulfonimide Under Mild Conditions. Chem. Res. Chin. Univ. 34, 191–196 (2018). https://doi.org/10.1007/s40242-018-7305-0

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  • DOI: https://doi.org/10.1007/s40242-018-7305-0

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