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A highly selective and sensitive ratiometric fluorescent probe for pH measurement based on fluorescence resonance energy transfer

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Abstract

Fluorescein-rhodamine 6G(Flu-Rh) was synthesized and used as the fluorescence probe for pH measurement based on fluorescence resonance energy transfer(FRET). In the probe, fluorescein fluorophore and pH-sensitive rhodamine 6G hydrazide were used as FRET donor and acceptor, respectively. The values of acidity constant(pK a) and fluorescence quantum yield(Φ) of Flu-Rh were 3.71 and 0.72, respectively. The fluorescence efficiency of Flu-Rh remains almost constant when the pH value of the sample solution changed 10 times in a range of 4.78–7.03 continuously. The present probe is simple and easy-to-use for the pH measurement in acidic media.

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Authors and Affiliations

  1. Department of Pharmacy, Changchun Medical College, Changchun, 130031, P. R. China

    Fanghui Liang

  2. College of Chemistry, Jilin University, Changchun, 130012, P. R. China

    Di Wang, Pinyi Ma, Xinghua Wang & Daqian Song

  3. College of Instrumentation & Electrical Engineering, Jilin University, Changchun, 130061, P. R. China

    Yong Yu

Authors
  1. Fanghui Liang
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  2. Di Wang
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  3. Pinyi Ma
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  4. Xinghua Wang
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  5. Daqian Song
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  6. Yong Yu
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Corresponding author

Correspondence to Yong Yu.

Additional information

Supported by the National Natural Science Foundation of China(Nos.21405057, 21207047) and the Science and Technology Developing Foundation of Jilin Province, China(No.20125006).

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Liang, F., Wang, D., Ma, P. et al. A highly selective and sensitive ratiometric fluorescent probe for pH measurement based on fluorescence resonance energy transfer. Chem. Res. Chin. Univ. 31, 724–729 (2015). https://doi.org/10.1007/s40242-015-5124-0

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  • DOI: https://doi.org/10.1007/s40242-015-5124-0

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