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Bone mass and microarchitecture in T2DM patients and corticosteroids therapy: the Bushehr Elderly Health program

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Abstract

Purpose

Our study examined whether T2DM and glucocorticoids treatment affect bone quality and quantity that are measured by Bone Mineral Density (BMD) and Trabecular Bone Score (TBS).

Materials & methods

Participants in this study were 2294 women and men aged over 60 years who participated in stage II of the Bushehr Elderly Health (BEH) program. Patients with T2DM and those who received glucocorticoids were included. BMD was detected using the DXA method and the TBS of L1-L4 was evaluated by TBS iNsight® software. To evaluate the correlation between TBS and BMD levels with diabetes and taking corticosteroids sex-specific multivariable linear regression models were appplied.

Results

TBS and BMD were not significantly different in those who had received glucocorticoids versus those who did not.T2DM revealed a significant association with both BMD and TBS in men (beta = 0.12, p < 0.001 and beta = 0.063, p = 0.03, respectively). BMD values were significantly higher in diabetic women (beta = 0.073, p < 0.01). BMI had a significant association with both TBS and BMD but in an opposite direction, in women and men (BMD: beta = -0.22, -0.24, and regarding TBS: beta = 0.37, 0.25, all p-values < 0.001).

Conclusion

Our findings showed that T2DM had major effects on BMD in both men and women. However, T2DM only affects TBS in men. Furthermore, neither BMD nor TBS were affected by GC intake in men or women.Based on the variable importance of covariates, BMI was the most influential factor on both BMD and TBS, although in opposite directions, in both sexes.

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Acknowledgements

The authors would like to thank Tehran University of Medical Sciences and Buchehr university of medical sciences for kind supports.

Funding

IR.TUMS.EMRI.REC.1394.0036.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, Pasteur Institute of Iran, Tehran, Iran

    Safoora Gharibzadeh

  2. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Golnaz Goodarzi & Sadra Samavarchi Tehrani

  3. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, No.10- Jalal –e-ale-ahmad st, Chamran hwy, P. O. Box: 14117-13137, Tehran, Iran

    Noushin Fahimfar, Mahnaz Sanjari, Kazem Khalagi & Afshin Ostovar

  4. Metabolomics and Genomics Research Center Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Farideh Razi

  5. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Farideh Razi

  6. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Kazem Khalagi

  7. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Gita Shafiee & Ramin Heshmat

  8. Division of Rheumatology, Department of Internal Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran

    Azam Amini

  9. The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran

    Iraj Nabipour

  10. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Bagher Larijani

Authors
  1. Safoora Gharibzadeh
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  2. Golnaz Goodarzi
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  3. Sadra Samavarchi Tehrani
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  8. Gita Shafiee
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  13. Afshin Ostovar
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Correspondence to Afshin Ostovar.

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This study approved by the Research Ethics Committee of both Bushehr University of Medical Sciences and Endocrinology and Metabolism Research Institute.

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Gharibzadeh, S., Goodarzi, G., Tehrani, S.S. et al. Bone mass and microarchitecture in T2DM patients and corticosteroids therapy: the Bushehr Elderly Health program. J Diabetes Metab Disord 21, 717–725 (2022). https://doi.org/10.1007/s40200-022-01040-0

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