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Prehabilitation in the Older People: Current Developments

  • GERIATRIC ANESTHESIA (S AKHTAR, SECTION EDITOR)
  • Published:
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Abstract

Purpose of Review

This review aims to provide an overview of the current evidence for prehabilitation in frail, older surgical patients and to provide a pragmatic approach for implementation into routine perioperative care.

Recent Findings

There is increasing evidence for the use of prehabilitation strategies to improve postoperative outcomes. However, there is heterogeneity in the components of prehabilitation programs studied. Furthermore, they have not been robustly examined in a frail older population.

Summary

Older patients are frequently frail and at increased risk of adverse postoperative outcomes. This group may benefit from prehabilitation. A consistent approach to screening, assessment, and optimization across multiple domains using an interdisciplinary approach should be used to examine this robustly.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. West MA, Jack S, Grocott MPW. Prehabilitation before surgery: is it for all patients? Best Pract Res Clin Anaesthesiol. 2021. https://doi.org/10.1016/j.bpa.2021.01.001.

  2. Daniels SL, Lee MJ, George J, Kerr K, Moug S, Wilson TR, Brown SR, Wyld L. Prehabilitation in elective abdominal cancer surgery in older patients: systematic review and meta-analysis. BJS Open. 2020;4:1022–41.

    Article  Google Scholar 

  3. Molenaar CJL, Papen-Botterhuis NE, Herrle F, Slooter GD. Prehabilitation, making patients fit for surgery - a new frontier in perioperative care. Innov Surg Sci. 2019;4:132–8.

    PubMed  PubMed Central  Google Scholar 

  4. Etzioni DA, Liu JH, Maggard MA, Ko CY. The aging population and its impact on the surgery workforce. Ann Surg. 2003;238:170–7.

    PubMed  PubMed Central  Google Scholar 

  5. Fowler AJ, Abbott TEF, Prowle J, Pearse RM. Age of patients undergoing surgery. Br J Surg. 2019;106:1012–8.

    Article  CAS  Google Scholar 

  6. Lin HS, Watts JN, Peel NM, Hubbard RE. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr. 2016;16:157.

    Article  Google Scholar 

  7. van Zutphen M, Winkels RM, van Duijnhoven FJB, et al. An increase in physical activity after colorectal cancer surgery is associated with improved recovery of physical functioning: a prospective cohort study. BMC Cancer. 2017;17:74.

    Article  Google Scholar 

  8. McIsaac DI, Taljaard M, Bryson GL, et al. Frailty and long-term postoperative disability trajectories: a prospective multicentre cohort study. Br J Anaesth. 2020;125:704–11.

    Article  Google Scholar 

  9. Watt J, Tricco AC, Talbot-Hamon C, Pham B, Rios P, Grudniewicz A, Wong C, Sinclair D, Straus SE. Identifying older adults at risk of harm following elective surgery: a systematic review and meta-analysis. BMC Med. 2018. https://doi.org/10.1186/s12916-017-0986-2.

  10. Hung YC, Wolf JH, D'Adamo CR, Demos J, Katlic MR, Svoboda S. Preoperative functional status is associated with discharge to nonhome in geriatric individuals. J Am Geriatr Soc. 2021. https://doi.org/10.1111/jgs.17128.

  11. Minnella EM, Awasthi R, Loiselle SE, Agnihotram RV, Ferri LE, Carli F. Effect of exercise and nutrition prehabilitation on functional capacity in esophagogastric cancer surgery: a randomized clinical trial. JAMA Surg. 2018;153:1081–9.

    Article  Google Scholar 

  12. Minnella EM, Awasthi R, Bousquet-Dion G, Ferreira V, Austin B, Audi C, Tanguay S, Aprikian A, Carli F, Kassouf W (2019) Multimodal prehabilitation to enhance functional capacity following radical cystectomy: a randomized controlled trial. Eur Urol Focus 7(1):132–138. https://doi.org/10.1016/j.euf.2019.05.016.

  13. Carli F, Bousquet-Dion G, Awasthi R, et al. Effect of multimodal prehabilitation vs postoperative rehabilitation on 30-day postoperative complications for frail patients undergoing resection of colorectal cancer: a randomized clinical trial. JAMA Surg. 2020;155:233–42.

    Article  Google Scholar 

  14. Jensen BT, Petersen AK, Jensen JB, Laustsen S, Borre M. Efficacy of a multiprofessional rehabilitation programme in radical cystectomy pathways: a prospective randomized controlled trial. Scand J Urol. 2015;49:133–41.

    Article  Google Scholar 

  15. Bousquet-Dion G, Awasthi R, Loiselle SÈ, Minnella EM, Agnihotram RV, Bergdahl A, Carli F, Scheede-Bergdahl C. Evaluation of supervised multimodal prehabilitation programme in cancer patients undergoing colorectal resection: a randomized control trial. Acta Oncol (Madr). 2018;57:849–59.

    Article  Google Scholar 

  16. Kaibori M, Ishizaki M, Matsui K, Nakatake R, Yoshiuchi S, Kimura Y, Kwon AH. Perioperative exercise for chronic liver injury patients with hepatocellular carcinoma undergoing hepatectomy. Am J Surg. 2013;206:202–9.

    Article  Google Scholar 

  17. Ausania F, Senra P, Meléndez R, Caballeiro R, Ouviña R, Casal-Núñez E. Prehabilitation in patients undergoing pancreaticoduodenectomy: a randomized controlled trial. Rev Esp Enferm Dig. 2019;111:603–8.

    Article  Google Scholar 

  18. Gillis C, Li C, Lee L, et al. Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer. Anesthesiology. 2014;121:937–47.

    Article  Google Scholar 

  19. Fulop A, Lakatos L, Susztak N, Szijarto A, Banky B. The effect of trimodal prehabilitation on the physical and psychological health of patients undergoing colorectal surgery: a randomised clinical trial. Anaesthesia. 2021;76:82–90.

    Article  CAS  Google Scholar 

  20. Gillis C, Fenton TR, Sajobi TT, Minnella EM, Awasthi R, Loiselle SÈ, Liberman AS, Stein B, Charlebois P, Carli F. Trimodal prehabilitation for colorectal surgery attenuates post-surgical losses in lean body mass: a pooled analysis of randomized controlled trials. Clin Nutr. 2019;38:1053–60.

    Article  Google Scholar 

  21. Schneeweiss S, Maclure M. Use of comorbidity scores for control of confounding in studies using administrative databases. Int J Epidemiol. 2000;29:891–8.

    Article  CAS  Google Scholar 

  22. Sharma N, Schwendimann R, Endrich O, Ausserhofer D, Simon M. Comparing Charlson and Elixhauser comorbidity indices with different weightings to predict in-hospital mortality: an analysis of national inpatient data. BMC Health Serv Res. 2021;21:1–10.

    Article  Google Scholar 

  23. Haren A, Lal R, Walker D, Nair R, Partridge J, Dhesi J. Frailty assessment in older urological patients prior to surgery: a systematic review and narrative synthesis. Ther Adv Urol. 2020. https://doi.org/10.1177/1756287220916614.

  24. Partridge JSL, Harari D, Dhesi JK. Frailty in the older surgical patient: a review. Age Ageing. 2012;41:142–7.

    Article  Google Scholar 

  25. Czigany Z, Kramp W, Bednarsch J, Kroft G, Boecker J, Strnad P, Zimmermann M, Koek G, Neumann UP, Lurje G. Myosteatosis to predict inferior perioperative outcome in patients undergoing orthotopic liver transplantation. Am J Transplant. 2020;20:493–503.

    Article  Google Scholar 

  26. Hayes SC, Newton RU, Spence RR, Galvão DA. The Exercise and Sports Science Australia position statement: exercise medicine in cancer management. J Sci Med Sport. 2019;22:1175–99.

    Article  Google Scholar 

  27. Rengel KF, Mehdiratta N, Vanston SW, Archer KR, Jackson JC, Thompson JL, Pandharipande PP, Hughes CG. A randomised pilot trial of combined cognitive and physical exercise prehabilitation to improve outcomes in surgical patients. Br J Anaesth. 2021;126:e55–7.

    Article  Google Scholar 

  28. Puts MTE, Toubasi S, Andrew MK, et al. Interventions to prevent or reduce the level of frailty in community-dwelling older adults: a scoping review of the literature and international policies. Age Ageing. 2017;46:383–92.

    PubMed  PubMed Central  Google Scholar 

  29. Vetrano DL, Palmer K, Marengoni A, Marzetti E, Lattanzio F, Roller-Wirnsberger R, Samaniego LL, Rodríguez-Mañas L, Bernabei R, Onder G. Frailty and multimorbidity: a systematic review and meta-analysis. J Gerontol - Ser A Biol Sci Med Sci. 2019;74:659–66.

    Article  Google Scholar 

  30. Barnett K, Mercer SW, Norbury M, Watt G, Wyke S, Guthrie B. Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study. Lancet. 2012;380:37–43.

    Article  Google Scholar 

  31. Weiss CO. Frailty and chronic diseases in older adults. Clin Geriatr Med. 2011;27:39–52.

    Article  Google Scholar 

  32. Ellis G, Gardner M, Tsiachristas A, et al. Comprehensive geriatric assessment for older adults admitted to hospital. Cochrane Database Syst Rev. 2017. https://doi.org/10.1002/14651858.CD006211.pub3.

  33. Rubenstein LZ, Stuck AE, Siu AL, Wieland D. Impacts of geriatric evaluation and management programs on defined outcomes: overview of the evidence. J Am Geriatr Soc. 1991;39:8S–16S.

    Article  CAS  Google Scholar 

  34. Eamer G, Taheri A, Chen SS, Daviduck Q, Chambers T, Shi X, Khadaroo RG. Comprehensive geriatric assessment for older people admitted to a surgical service. Cochrane Database Syst Rev. 2018. https://doi.org/10.1002/14651858.CD012485.pub2.

  35. Partridge JSL, Harari D, Martin FC, Peacock JL, Bell R, Mohammed A, Dhesi JK. Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery. Br J Surg. 2017;104:679–87.

    Article  CAS  Google Scholar 

  36. Partridge J, Healey A, Modarai B, Harari D, Martin F, Dhesi J. Preoperative comprehensive geriatric assessment and optimisation prior to elective arterial vascular surgery; a health economic analysis. Age Ageing. 50:1770–7.

  37. Saripella A, Wasef S, Nagappa M, Riazi S, Englesakis M, Wong J, Chung F. Effects of comprehensive geriatric care models on postoperative outcomes in geriatric surgical patients: a systematic review and meta-analysis. BMC Anesthesiol. 2021;21:1–11.

    Article  Google Scholar 

  38. Joughin AL, Partridge JSL, O'Halloran T, Dhesi JK. Where are we now in perioperative medicine? Results from a repeated UK survey of geriatric medicine delivered services for older people. Age Ageing. 2019;48:458–62.

    Article  Google Scholar 

  39. •• The American College of Surgeons (2019) Geriatric Surgery Verification Program. https://www.facs.org/quality-programs/geriatric-surgery. Accessed 21 May 2021, The American College of Surgeons (ACS) Geriatric Surgery Verification (GSV) Program provides a set of recommendations designed to improve the care and outcomes for the older population undergoing surgery.

  40. • Chow WB, Rosenthal RA, Merkow RP, Ko CY, Esnaola NF (2012) Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society. J Am Coll Surg 215(4):453–66. This American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP)/American Geriatrics Society (AGS) Best Practices Guidelines provides recommendations on the optimal preoperative assessment of the geriatric surgical patient.

  41. Dhesi J (2013) Peri-operative care for older patients undergoing surgery. Peri-operative Care Older Patients Undergoing Surg Br Geriatr Soc

  42. Griffiths R, Beech F, Brown A, Dhesi J, Foo I, Goodall J, Harrop-Griffiths W, Jameson J, Love N, Pappenheim K, White S (2014) Peri-operative care of the elderly 2014: Association of Anaesthetists of Great Britain and Ireland. Anaesthesia 69:81–98.

  43. British Geriatrics Society (2015) Fit for frailty–part 2: developing, commissioning and managing services for people living with frailty in community settings. Section 2. Accessed 6 May 2021.

  44. Care PO (2021) The Higher Risk General Surgical Patient: Towards improved care for a forgotten group. https://www.rcseng.ac.uk/library-and-publications/rcs-publications/docs/the-higher-risk-general-surgical-patient/. Accessed 6 May 2021

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Correspondence to Amanda Tsan Yue Siu.

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Conflict of Interest

Dr. Jugdeep Dhesi, Dr. Tom Poulton, and Dr. Amanda Tsan Yue Siu declare they have no conflict of interest. Prof. Bernhard Riedel and Dr. Hilmy Ismail are co-directors of Fit-4-Surgery Pvt Ltd, Australia.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Geriatric Anesthesia

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Siu, A.T.Y., Poulton, T., Ismail, H. et al. Prehabilitation in the Older People: Current Developments. Curr Anesthesiol Rep 11, 373–380 (2021). https://doi.org/10.1007/s40140-021-00496-9

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