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Oxygenation and Ventilation Strategies for Patients Undergoing Lung Resection Surgery After Prior Lobectomy or Pneumonectomy

  • Thoracic Anesthesia (T Schilling, Section Editor)
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Abstract

Lung resection surgery after a prior lobectomy or pneumonectomy is becoming more prevalent. Elevated shunt fractions and reduced functional lung parenchyma complicate one-lung ventilation in the patient with a prior contralateral lobectomy. Meanwhile, lung resection after pneumonectomy requires reliance on the solitary, surgical lung for adequate oxygenation and ventilation without impeding surgical progress. These challenges require appropriate preoperative investigations and planning to facilitate a technique that balances the need for adequate gas exchange and lung injury prevention with the desire for sufficient exposure to allow for a complete surgical resection and optimal oncologic outcomes.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Jaklitsch MT, Jacobson FL, Austin JH, Field JK, Jett JR, Keshavjee S, et al. The American Association for Thoracic Surgery guidelines for lung cancer screening using low-dose computed tomography scans for lung cancer survivors and other high-risk groups. J Thorac Cardiovasc Surg. 2012;144(1):33–8.

    Article  PubMed  Google Scholar 

  2. Lou F, Huang J, Sima CS, Dycoco J, Rusch V, Bach PB. Patterns of recurrence and second primary lung cancer in early-stage lung cancer survivors followed with routine computed tomography surveillance. J Thorac Cardiovasc Surg. 2013;145(1):75–81 (discussion 81–2).

    Article  PubMed  Google Scholar 

  3. Donington J, Ferguson M, Mazzone P, Handy J Jr, Schuchert M, Fernando H, et al. American college of chest physicians and society of thoracic surgeons consensus statement for evaluation and management for high-risk patients with stage I non-small cell lung cancer. CHEST J. 2012;142(6):1620–35.

    Article  Google Scholar 

  4. Walsh AM, Lohser J. Arterial oxygenation and management of hypoxemia during VATS. Curr Anesthesiol Rep. 2014;4:170–6.

    Article  Google Scholar 

  5. Ruiz P, Kovarik G. Lung mechanics and gas exchange in one-lung ventilation following contralateral resection. Can J Anesth/Journal Canadien D’anesthésie. 2005;52(9):986–9.

    Article  PubMed  Google Scholar 

  6. •• Toufektzian L, Patris V, Potaris K, Konstantinou M. Is it safe and worthwhile to perform pulmonary resection after contralateral pneumonectomy? Interact Cardiovasc Thorac Surg. 2015;20(2):265–9. Best evidence topic suggesting pulmonary resection after pneumonectomy is rare but has an acceptable morbidity and mortality, especially with sublobar resections.

  7. Jiang L, He J, Shi X, Shen J, Liang W, Yang C, He J. Prognosis of synchronous and metachronous multiple primary lung cancers: systematic review and meta-analysis. Lung Cancer. 2015;87(3):303–10.

    Article  PubMed  Google Scholar 

  8. Ha D, Choi H, Chevalier C, Zell K, Wang X-F, Mazzone PJ. Survival in patients with metachronous second primary lung cancer. Ann Am Thorac Soc. 2015;12(1):79–84.

    Article  PubMed  Google Scholar 

  9. Pairolero PC, Williams DE, Bergstralh EJ, Piehler JM, Bernatz PE, Payne WS. Postsurgical stage I bronchogenic carcinoma: morbid implications of recurrent disease. Ann Thorac Surg. 1984;38(4):331–8.

    Article  CAS  PubMed  Google Scholar 

  10. Kozower BD, Larner JM, Detterbeck FC, Jones DR. Special treatment issues in non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e369S–99S.

    Article  PubMed  Google Scholar 

  11. Hamaji M, Allen MS, Cassivi SD, Deschamps C, Nichols FC, Wigle DA, Shen KR. Surgical treatment of metachronous second primary lung cancer after complete resection of non-small cell lung cancer. J Thorac Cardiovasc Surg. 2013;145(3):683–90 (discussion 690–1).

    Article  PubMed  Google Scholar 

  12. Graham EA, Singer JJ. Successful removal of an entire lung for carcinoma of the bronchus. J Am Med Assoc. 1933;101(18):1371–4.

    Article  Google Scholar 

  13. Churchill ED, Sweet RH, Soutter L, Scannell JG. The surgical management of carcinoma of the lung; a study of the cases treated at the Massachusetts General Hospital from 1930 to 1950. J Thorac Surg. 1950;20(3):349.

    CAS  PubMed  Google Scholar 

  14. Deslauriers J, Ugalde P, Miro S, Deslauriers DR, Ferland S, Bergeron S, et al. Long-term physiological consequences of pneumonectomy. Semin Thorac Cardiovasc Surg. 2011;23(3):196–202.

    Article  PubMed  Google Scholar 

  15. Stiles QR, Meyer BW, Lindesmith GG, Jones JC. The effects of pneumonectomy in children. J Thorac Cardiovasc Surg. 1969;58(3):394.

    Article  CAS  PubMed  Google Scholar 

  16. Laros CD, Westermann CJ. Dilatation, compensatory growth, or both after pneumonectomy during childhood and adolescence. A thirty-year follow-up study. J Thorac Cardiovasc Surg. 1987;93(4):570–6.

    Article  CAS  PubMed  Google Scholar 

  17. Butler JP, Loring SH, Patz S, Tsuda A, Yablonskiy DA, Mentzer SJ. Evidence for adult lung growth in humans. N Engl J Med. 2012;367(3):244–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Birath G, Crafoord C, Rudstrom P. Pulmonary function after pneumonectomy and lobectomy. J Thorac Surg. 1947;16(5):492.

    CAS  PubMed  Google Scholar 

  19. McIlroy MB, Bates DV. Respiratory function after pneumonectomy. Thorax. 1956;11(4):303–11.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Jones JC, Robinson JL, Meyer BW, Motley HL. Primary carcinoma of the lung. A follow-up study including pulmonary function studies of long-term survivors. J Thorac Cardiovasc Surg. 1960;39:144–58.

    Article  CAS  PubMed  Google Scholar 

  21. Olsen GN, Block AJ, Tobias JA. Prediction of postpneumonectomy pulmonary function using quantitative macroaggregate lung scanning. CHEST J. 1974;66(1):13–6.

    Article  CAS  Google Scholar 

  22. Legge JS, Palmer KN. Effect of lung resection for bronchial carcinoma on pulmonary function in patients with and without chronic obstructive bronchitis. Thorax. 1975;30(5):563–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Dunn EJ, Hernandez J, Bender HW, Prager RL. Alterations in pulmonary function following pneumonectomy for bronchogenic carcinoma. Ann Thorac Surg. 1982;34(2):176–80.

    Article  CAS  PubMed  Google Scholar 

  24. Hjalmarsen A, Aasebø U, Lie M. Pulmonary function 3–12 months after pneumonectomy, lobectomy or bilobectomy for lung cancer. Scand Cardiovasc J. 1995;29(2):71–4.

    CAS  Google Scholar 

  25. Kushibe K, Kawaguchi T, Kimura M, Takahama M, Tojo T, Taniguchi S. Changes in ventilatory capacity, exercise capacity, and pulmonary blood flow after lobectomy in patients with lung cancer–which lobectomy has the most loss in exercise capacity? Interact CardioVasc Thorac Surg. 2008;7(6):1011–4.

    Article  PubMed  Google Scholar 

  26. Ueda K, Tanaka T, Hayashi M, Li TS, Kaneoka T, Tanaka N, Hamano K. Compensation of pulmonary function after upper lobectomy versus lower lobectomy. J Thorac Cardiovasc Surg. 2011;142(4):762–7.

    Article  PubMed  Google Scholar 

  27. Mizobuchi T, Wada H, Sakairi Y, Suzuki H, Nakajima T, Tagawa T, et al. Spirometric and radiological evaluation of the remnant lung long after major pulmonary resection: can compensatory phenomena be recognized in clinical cases? Surg Today. 2014;44(9):1735–43.

    Article  PubMed  Google Scholar 

  28. Ueda K, Hayashi M, Tanaka N, Tanaka T, Hamano K. Long-term pulmonary function after major lung resection. Gen Thorac Cardiovasc Surg. 2014;62(1):24–30.

    Article  PubMed  Google Scholar 

  29. Brown MS, Kim HJ, Abtin FG, Strange C, Galperin-Aizenberg M, Pais R, et al. Emphysema lung lobe volume reduction: effects on the ipsilateral and contralateral lobes. Eur Radiol. 2012;22(7):1547–55.

    Article  PubMed  Google Scholar 

  30. Win T, Groves AM, Ritchie AJ, Wells FC, Cafferty F, Laroche CM. The effect of lung resection on pulmonary function and exercise capacity in lung cancer patients. Respir Care. 2007;52(6):720–6.

    PubMed  Google Scholar 

  31. Nagamatsu Y, Maeshiro K, Kimura NY, Nishi T, Shima I, Yamana H, Shirouzu K. Long-term recovery of exercise capacity and pulmonary function after lobectomy. J Thorac Cardiovasc Surg. 2007;134(5):1273–8.

    Article  PubMed  Google Scholar 

  32. Nugent AM, Steele IC, Carragher AM, McManus K, McGuigan JA, Gibbons JRP, et al. Effect of thoracotomy and lung resection on exercise capacity in patients with lung cancer. Thorax. 1999;54(4):334–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Krishnan S, Schmidt GA. Acute right ventricular dysfunction: real-time management with echocardiography. Chest. 2015;147(3):835–46.

    Article  PubMed  Google Scholar 

  34. Cooper R, Ghali J, Simmons BE, Castaner A. Elevated pulmonary artery pressure. An independent predictor of mortality. CHEST J. 1991;99(1):112–20.

    Article  CAS  Google Scholar 

  35. Venuta F, Sciomer S, Andreetti C, Anile M, De Giacomo T, Rolla M, et al. Long-term doppler echocardiographic evaluation of the right heart after major lung resections. Eur J Cardiothorac Surg. 2007;32(5):787–90.

    Article  PubMed  Google Scholar 

  36. Deslauriers J, Ugalde P, Miro S, Ferland S, Bergeron S, Lacasse Y, Provencher S. Adjustments in cardiorespiratory function after pneumonectomy: results of the pneumonectomy project. J Thorac Cardiovasc Surg. 2011;141(1):7–15.

    Article  PubMed  Google Scholar 

  37. • Potaris K, Athanasiou A, Konstantinou M, Zaglavira P, Theodoridis D, Syrigos KN. Pulmonary hypertension after pneumonectomy for lung cancer. Asian Cardiovasc Thorac Ann. 2014;22(9):1072–9. Observational prospective cohort study demonstrating mild to moderate pulmonary hypertension post-pneumonectomy correlates with worse clinical outcomes.

  38. Okada M, Okada M, Ishii N, Yamashita C, Sugimoto T, Okada K, et al. Right ventricular ejection fraction in the preoperative risk evaluation of candidates for pulmonary resection. J Thorac Cardiovasc Surg. 1996;112(2):364–70.

    Article  CAS  PubMed  Google Scholar 

  39. Wei B, D’Amico T, Samad Z, Hasan R, Berry MF. The impact of pulmonary hypertension on morbidity and mortality following major lung resection. Eur J Cardiothorac Surg. 2014;45(6):1028–33.

    Article  PubMed  Google Scholar 

  40. Slinger PD, Johnston MR. Preoperative assessment for pulmonary resection. J Cardiothorac Vasc Anesth. 2000;14(2):202–11.

    Article  CAS  PubMed  Google Scholar 

  41. Brunelli A, Kim AW, Berger KI, Addrizzo-Harris DJ. Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e166S–90S.

    Article  CAS  PubMed  Google Scholar 

  42. Mercier O, de Perrot M, Keshavjee S. Pulmonary resection after pneumonectomy. Thorac Surg Clin. 2014;24(4):433–9.

    Article  PubMed  Google Scholar 

  43. Griffin JP, Eastridge CE, Tolley EA, Pate JW. Wedge resection for non-small cell lung cancer in patients with pulmonary insufficiency: prospective ten-year survival. J Thorac Oncol. 2006;1(9):960–4.

    Article  PubMed  Google Scholar 

  44. •• Lohser J, Slinger P. Lung injury after one-lung ventilation: a review of the pathophysiologic mechanisms affecting the ventilated and the collapsed lung. Anesth Analg. 2015;121(2):302–18. Comprehensive review of the contributors to lung injury during OLV with best practice recommendations.

  45. Lohser J. Managing hypoxemia during minimally invasive thoracic surgery. Anesthesiol Clin. 2012;30(4):683–97.

    Article  PubMed  Google Scholar 

  46. Berend N, Woolcock AJ, Marlin GE. Effects of lobectomy on lung function. Thorax. 1980;35(2):145–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Donington JS, Miller DL, Rowland CC, Deschamps C, Allen MS, Trastek VF, Pairolero PC. Subsequent pulmonary resection for bronchogenic carcinoma after pneumonectomy. Ann Thorac Surg. 2002;74(1):154–8 (discussion 158–9).

    Article  PubMed  Google Scholar 

  48. Grodzki T, Alchimowicz J, Kozak A, Kubisa B, Pieróg J, Wójcik J, et al. Additional pulmonary resections after pneumonectomy: actual long-term survival and functional results. Eur J Cardiothorac Surg. 2008;34(3):493–8.

    Article  PubMed  Google Scholar 

  49. Lang J, Hartman M. Use of a left-sided double-lumen endotracheal tube in a patient with a prior left pneumonectomy. AANA J. 2013;81(5):369.

    PubMed  Google Scholar 

  50. Misiolek H, Knapik P, Swanevelder J, Wyatt R, Misiolek M. Comparison of double-lung jet ventilation and one-lung ventilation for thoracotomy. Eur J Anaesthesiol. 2008;25(1):15–21.

    Article  CAS  PubMed  Google Scholar 

  51. Ender J, Brodowsky M, Falk V, Baunsch J, Koncar-Zeh J, Kaisers UX, Mukherjee C. High-frequency jet ventilation as an alternative method compared to conventional one-lung ventilation using double-lumen tubes during minimally invasive coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2010;24(4):602–7.

    Article  PubMed  Google Scholar 

  52. Ishiyama T, Iwashita H, Shibuya K, Terada Y, Masamune T, Nakadate Y, Matsukawa T. High-frequency jet ventilation during video-assisted thoracoscopic surgery in a patient with previous contralateral pneumonectomy. J Clin Anesth. 2013;25(1):55–7.

    Article  PubMed  Google Scholar 

  53. Lohser J, McLean SR. Thoracoscopic wedge resection of the lung using high-frequency jet ventilation in a postpneumonectomy patient. A&A Case Rep. 2013;1(2):39–41.

    Article  Google Scholar 

  54. Terzi A, Furlan G, Gorla A, Falezza G, Attino M, Calabro F. Lung resection on single residual lung after pneumonectomy for bronchogenic carcinoma. Thorac Cardiovasc Surg. 1997;45(6):273–6.

    Article  CAS  PubMed  Google Scholar 

  55. Ishikawa N, Sato H, Hiranuma C, Takizawa M. A surgical intervention using percutaneous cardiopulmonary support for contralateral pneumothorax following pneumonectomy. Ann Thorac Cardiovasc Surg. 2001;7(4):235–6.

    CAS  PubMed  Google Scholar 

  56. Oey IF, Peek GJ, Firmin RK, Waller DA. Post-pneumonectomy video-assisted thoracoscopic bullectomy using extra-corporeal membrane oxygenation. Eur J Cardiothorac Surg. 2001;20(4):874–6.

    Article  CAS  PubMed  Google Scholar 

  57. Lohser J. Evidence-based management of one-lung ventilation. Anesthesiol Clin. 2008;26(2):241–72.

    Article  PubMed  Google Scholar 

  58. Swanson SJ, Meyers BF, Gunnarsson CL, Moore M, Howington JA, Maddaus MA, et al. Video-assisted thoracoscopic lobectomy is less costly and morbid than open lobectomy: a retrospective multiinstitutional database analysis. Ann Thorac Surg. 2012;93(4):1027–32.

    Article  PubMed  Google Scholar 

  59. Ceppa DP, Kosinski AS, Berry MF, Tong BC, Harpole DH, Mitchell JD, et al. Thoracoscopic lobectomy has increasing benefit in patients with poor pulmonary function: a society of thoracic surgeons database analysis. Ann Surg. 2012;256(3):487–93.

    Article  PubMed  Google Scholar 

  60. Morikawa T, Sugiura H, Kaji M, Sasamura Y, Okushiba S, Kondo S, et al. Availability of lobe-selective bronchial blockade for video-assisted thoracic surgery: an initial experience with three cases. Surg Endosc. 2002;16(2):327–30.

    Article  CAS  PubMed  Google Scholar 

  61. Tsitsias T, Gupta P, Lau KW, Harvey N, Rathinam S. Pulmonary resection for metachronous lung cancer following contralateral pneumonectomy. Open J Thorac Surg. 2013;3(1):15–18.

    Article  Google Scholar 

  62. Chen J-S, Cheng Y-J, Hung M-H, Tseng Y-D, Chen K-C, Lee Y-C. Nonintubated thoracoscopic lobectomy for lung cancer. Ann Surg. 2011;254(6):1038–43.

    Article  PubMed  Google Scholar 

  63. Chen K-C, Cheng Y-J, Hung M-H, Tseng Y-D, Chen J-S. Nonintubated thoracoscopic lung resection: a 3-year experience with 285 cases in a single institution. J Thorac Dis. 2012;4(4):347.

    PubMed  PubMed Central  Google Scholar 

  64. Hung MH, Hsu HH, Chen KC, Chan KC, Cheng YJ, Chen JS. Nonintubated thoracoscopic anatomical segmentectomy for lung tumors. Ann Thorac Surg. 2013;96(4):1209–15.

    Article  PubMed  Google Scholar 

  65. Pompeo E, Mineo D, Rogliani P, Sabato AF, Mineo TC. Feasibility and results of awake thoracoscopic resection of solitary pulmonary nodules. Ann Thorac Surg. 2004;78(5):1761–8.

    Article  PubMed  Google Scholar 

  66. Perrin C, Jullien V, Vénissac N, Berthier F, Padovani B, Guillot F, et al. Prophylactic use of noninvasive ventilation in patients undergoing lung resectional surgery. Respir Med. 2007;101(7):1572–8.

    Article  PubMed  Google Scholar 

  67. Auriant I, Jallot A, Hervé P, Cerrina J, Le Roy Ladurie F, Fournier JL, et al. Noninvasive ventilation reduces mortality in acute respiratory failure following lung resection. Am J Respir Crit Care Med. 2001;164(7):1231–5.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Jens Lohser.

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This article is part of the Topical Collection on Thoracic Anesthesia.

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Durkin, C., Lohser, J. Oxygenation and Ventilation Strategies for Patients Undergoing Lung Resection Surgery After Prior Lobectomy or Pneumonectomy. Curr Anesthesiol Rep 6, 135–141 (2016). https://doi.org/10.1007/s40140-016-0153-x

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