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Recent studies on modulating hyaluronic acid-based hydrogels for controlled drug delivery

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Abstract

Background

Diverse hydrogel formulations have been investigated for topical and subcutaneous drug delivery. Among the various biopolymers used for hydrogel formulations, hyaluronic acid (HA) has been widely applied due to its nontoxicity, excellent biocompatibility and rheological properties. However, formulations of HA-based hydrogel drug delivery system have several challenges to overcome, including their initial burst drug release and lack of mechanical strength. Thus, diverse strategies have been investigated to control the drug release from HA-based hydrogels.

Area covered

This review introduces recent strategies to modulate HA-based hydrogels for the control of drug release profiles. Recent approaches that will be covered in this review include, (1) both chemical and non-covalent cross-linking methods to modulate the physical properties of hydrogels, (2) ionic cross-lining and host–guest interaction-based hydrogels, and (3) incorporation of amorphous microprecipitated bulk drug powder and drug-encapsulated nano/microparticles in hydrogel networks. These new techniques are being intensively studied to decrease burst release and to sustain the release of drugs.

Expert opinion

HA-based hydrogel formulations are useful platforms in various biomedical areas, including controlled drug delivery, tissue engineering and cosmetic fillers. Various physical and chemical strategies are being studied to overcome their limitations and enhance the versatility of clinical applications.

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Fig. 1
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reproduced with permission from publisher (Li et al. 2016)

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reproduced with permission from publisher (Lee et al. 2020b)

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reproduced with permission from publisher (Liu et al. 2018)

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Acknowledgements

This work was supported by National Research Foundation of Korea (NRF) grants funded by the Ministry of Science and ICT (Nos. NRF-2018R1A5A2024425, NRF-2018M3A7B4071203, and NRF-2020R1A2C2099983).

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  1. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, South Korea

    Min-Hwan Kim, Duy-Thuc Nguyen & Dae-Duk Kim

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  1. Min-Hwan Kim
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  2. Duy-Thuc Nguyen
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Correspondence to Dae-Duk Kim.

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Kim, MH., Nguyen, DT. & Kim, DD. Recent studies on modulating hyaluronic acid-based hydrogels for controlled drug delivery. J. Pharm. Investig. 52, 397–413 (2022). https://doi.org/10.1007/s40005-022-00568-w

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