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Human cystic echinococcosis in Hungary (2000–2014): a retrospective case series analysis from a single-center study

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Abstract

Purpose

Cystic echinococcosis (CE) is a parasitic disease caused by the tapeworm Echinococcus granulosus sensu lato. Although in Hungary the disease is listed among reportable infections, inadequacies in the reporting practice of CE by clinicians and pathologists have resulted in underscoring of this disease. The aim of this study was to describe the epidemiological and clinical characteristics of CE in Hungary using a datasource other than the official records that are based mainly on serological data.

Methods and Results

This retrospective case series study included a total of 45 CE patients confirmed by histopathology in a single Hungarian center between 2000 and 2014.

Conclusion

 Although CE is the most prevalent reportable endemic helminthosis in Hungary, to date this is the first study on the clinical epidemiology of the disease in this country.

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References

  1. McManus DP, Zhang W, Li J, Bartley PB. Echinococcosis. Lancet. 2003;362:1295–304. https://doi.org/10.1016/s0140-6736(03)14573-4.

    Article  PubMed  Google Scholar 

  2. Alvarez Rojas CA, Romig T, Lightowlers MW. Echinococcus granulosus sensu lato genotypes infecting humans—review of current knowledge. Int J Parasitol. 2014;44:9–18.https://doi.org/10.1016/j.ijpara.2013.08.008 (Epub 2013 Nov 19. Review).

    Article  PubMed  Google Scholar 

  3. Eckert J, Gemmell MA, Meslin F-X, Pawlowski ZS. WHO/OIE Manual on echinococcosis in humans and animals: a public health problem of global concern. Paris/Geneva: World Organization for Animal Health (Office International des Epizooties)/World Health Organization; 2001. Available from:http://whqlibdoc.who.int/publications/2001/929044522X.pdf.

  4. Possenti A, Manzano-Román R, Sánchez-Ovejero C, Boufana B, La Torre G, Siles-Lucas M, et al. Potential risk factors associated with human cystic echinococcosis: systematic review and meta-analysis. PLoS Negl Trop Dis. 2016;10:e0005114. https://doi.org/10.1371/journal.pntd.0005114.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Budke CM, Casulli A, Kern P, Vuitton DA. Cystic and alveolar echinococcosis: successes and continuing challenges. PLoS Negl Trop Dis. 2017;11:e0005477. https://doi.org/10.1371/journal.pntd.0005477. eCollection 2017 Apr.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Manzano-Román R, Sánchez-Ovejero C, Hernández-González A, Casulli A, Siles-Lucas M (2015) Serological diagnosis and follow-up of human cystic echinococcosis: a new hope for the future? Biomed Res Int 2015:428205. https://doi.org/10.1155/2015/428205. Epub 2015 Oct 4. Review.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Siles-Lucas M, Casulli A, Conraths FJ, Müller N. Laboratory diagnosis of Echinococcus spp. in human patients and infected animals. Adv Parasitol m. 2017;96:159–257. https://doi.org/10.1016/bs.apar.2016.09.003. Epub 2017 Jan 17.

    Article  CAS  Google Scholar 

  8. Brunetti E, Kern P, Vuitton DA. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop. 2010;114:1–16. https://doi.org/10.1016/j.actatropica.2009.11.001. [PMID: 19931502]

    Article  Google Scholar 

  9. Menezes da Silva A (2003 ) Hydatid cyst of the liver—criteria for the selection of appropriate treatment. Acta Trop. 85(2):237–42.

    Article  PubMed  CAS  Google Scholar 

  10. Dollinger Gy (1894) Máj és vese Echinococcus betegeken végzett műtétek. Orv Hetil. 38:590. [in Hungarian].

    Google Scholar 

  11. Doktor S. Echinococcus a medencében. Orv Hetil. 1901;45:565–6. [in Hungarian].

    Google Scholar 

  12. Beck B. Nyaki burkonytömlőkről Orv Hetil. 1896 40:321–3. [in Hungarian].

  13. Vas B. Az Echinococcus felismerése biológiai reactio segítségével. Orv Hetil. 1910;54:367–9. [in Hungarian].

    Google Scholar 

  14. Bársony T, Egan E. Az Echinococcus komplementkötés diagnostikai értékeléséről. Orvosi Hetilap 1912 56:597–600. [in Hungarian].

  15. Battyány I, Gasztonyi B, Hegedűs K, Erményi Á, Horváth L, Pár A. Policystás májbetegekben véletlenszerűen felismert máj Echinococcus cysták percutan drainage kezelése. Orv Hetil. 1999;140:2047–51. [in Hungarian].

    PubMed  Google Scholar 

  16. Román ET, Furák J, Bede O, Szénási, Zs. Tiszlavicz L. A tüdő echinococcus cystája gyermekkorban. Gyermekgyógyászat. 1999;2:106–11. [in Hungarian].

    Google Scholar 

  17. EFSA (European Food Safety Authority) and ECDC (European Centre for Disease Prevention and Control) (2017) The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2016. EFSA J 15:5077. https://doi.org/10.2903/j.efsa.2017.5077.

    Article  CAS  Google Scholar 

  18. Casulli A, Interisano M, Sreter T, Chitimia L, Kirkova Z, La Rosa G, Pozio E. Genetic variability of Echinococcus granulosus sensu stricto in Europe inferred by mitochondrial DNA sequences. Infect Genet Evol. 2012;12:377–83. https://doi.org/10.1016/j.meegid.2011.12.014. Epub 2012 Jan 5.

    Article  PubMed  CAS  Google Scholar 

  19. Edict VI.3./18/1998 of Hungarian Ministry of Social Welfare (Népjóléti Minisztérium; NM).

  20. Directive 2003/99/EC of the European Parliament and of the Council of 17 November 2003 on the monitoring of zoonoses and zoonotic agents, amending Council Decision 90/424/EEC and repealing Council Directive 92/117/EEC http://data.europa.eu/eli/dir/2003/99/2013-07-01.

  21. 30/1958 and 55.148/1960 EüM {Egészségügyi Minisztériumi} rendelet–Edict of Hungarian Ministry of Health.

  22. 2012/506/EU: Commission Implementing Decision of 8 August 2012 amending Decision 2002/253/EC laying down case definitions for reporting communicable diseases to the Community network under Decision No 2119/98/EC of the European Parliament and of the Council (notified under document C(2012) 5538) Text with EEA relevance http://data.europa.eu/eli/dec_impl/2012/506/oj.

  23. National Center for Epidemiology, Annual Data of the National Center for Epidemiology on communicable diseases notifiable in Hungary, EPINFO Special Issues 2001–2016.

  24. Informant sheet on the 20.period by the Hungarian Society of Sheep and Goat Breeding, 2015, Budapest.

  25. Rossi P, Tamarozzi F, Galati F, Pozio E, Akhan O, Cretu CM, Vutova K, Siles-Lucas M, Brunetti E, Casulli A. HERACLES extended network. The first meeting of the European Register of Cystic Echinococcosis (ERCE). Parasit Vectors. 2016;9:243. https://doi.org/10.1186/s13071-016-1532-3.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The research that will lead to these results has received funding from the European Community’s Seventh Framework Programme under the grant agreement 602051 (Project HERACLES; http://www.Heracles-fp7.eu/). The funding sources had no involvement in the preparation, ideas, writing, interpretation, or the decision to submit this article.

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Authors and Affiliations

  1. St. István and St. László Hospital, Budapest, Hungary

    Balázs Dezsényi

  2. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary

    Áron Somorácz

  3. National Center for Epidemiology, Budapest, Hungary

    József Danka & István Kucsera

  4. Institute of Pathology, Ulm University, Ulm, Germany

    Thomas F. E. Barth

  5. WHO Collaborating Centre for the Epidemiology, Detection and Control of Cystic and Alveolar Echinococcosis, Instituto Superiore di Sanita’, Rome, Italy

    Adriano Casulli

  6. European Union Reference Laboratory for Parasites (EURLP), Instituto Superiore di Sanita’, Rome, Italy

    Adriano Casulli

Authors
  1. Balázs Dezsényi
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  2. Áron Somorácz
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  3. József Danka
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  4. István Kucsera
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  5. Thomas F. E. Barth
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  6. Adriano Casulli
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Correspondence to Adriano Casulli.

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Dezsényi, B., Somorácz, Á., Danka, J. et al. Human cystic echinococcosis in Hungary (2000–2014): a retrospective case series analysis from a single-center study. Infection 46, 477–486 (2018). https://doi.org/10.1007/s15010-018-1146-0

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  • DOI: https://doi.org/10.1007/s15010-018-1146-0

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