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Iliac bone Candida albicans osteomyelitis in a patient with iliac crest bone autograft: a case report and review of the literature

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Abstract

Candida osteomyelitis is a well recognized but infrequent entity. We describe an interesting case of iliac bone C. albicans osteomyelitis as a result of a surgical trauma of an iliac bone for the auto-grafting of a fracture in the lumbar spine. The peri-operative acquisition of Candida was by the inoculation of a yeast colonizing the skin. Remarkably, several risk factors described for Candida infection and candidemia were absent. The patient also presented with a local fistula. The iliac crest was the only bone affected and local pain was the only symptom present in our case. Diagnosis was made by multiple-specimen biopsy obtained by surgery. Treatment with fluconazole was successful.

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References

  1. Waldvogel FA, Papageorgiou PS. Osteomyelitis: the past decade. N Engl J Med. 1980;303:360–70.

    Article  PubMed  CAS  Google Scholar 

  2. Lew DP, Waldvogel FA. Osteomyelitis. N Engl J Med. 1997;336:999–1007.

    Article  PubMed  CAS  Google Scholar 

  3. Belmatoug N, Crémieux AC, Bleton R, Volk A, Saleh-Mghir A, Grossin M, Garry L, Carbon C. A new model of experimental prosthetic joint infection due to methicillin-resistant Staphylococcus aureus: a microbiologic, histopathologic, and magnetic resonance imaging characterization. J Infect Dis. 1996;174:414–7.

    Article  PubMed  CAS  Google Scholar 

  4. Zimmerli W, Lew PD, Waldvogel FA. Pathogenesis of foreign body infection. Evidence for a local granulocyte defect. J Clin Invest. 1984;73:1191–200.

    Article  PubMed  CAS  Google Scholar 

  5. Wenzel RP. Nosocomial candidemia: risk factors and attributable mortality. Clin Infect Dis. 1995;20:1531–4.

    Article  PubMed  CAS  Google Scholar 

  6. Fraser VJ, Jones M, Dunkel J, Storfer S, Medoff G, Dunagan WC. Candidemia in a tertiary care hospital: epidemiology, risk factors, and predictors of mortality. Clin Infect Dis. 1992;15:414–21.

    Article  PubMed  CAS  Google Scholar 

  7. Arias F, Mata-Essayag S, Landaeta ME, Capriles CH, Pérez C, Núñez MJ, Carvajal A, Silva M. Candida albicans osteomyelitis: case report and literature review. Int J Infect Dis. 2004;8:307–14.

    PubMed  Google Scholar 

  8. Miller DJ, Mejicano GC. Vertebral osteomyelitis due to Candida species: case report and literature review. Clin Infect Dis. 2001;33:523–30.

    Article  PubMed  CAS  Google Scholar 

  9. Clinical and Laboratory Standards Institute (CLSI). Method for antifungal disk diffusion susceptibility testing of yeasts; Approved guideline—Second Edition. CLSI document M44-A2. CLSI, Wayne, PA. 2009.

  10. Potasman I, Leibovitz Z, Sharf M. Candida sepsis in pregnancy and the postpartum period. Rev Infect Dis. 1991;13:146–9.

    Article  PubMed  CAS  Google Scholar 

  11. Armstrong N, Schurr M, Helgerson R, Harms B. Fungal sacral osteomyelitis as the initial presentation of Crohn’s disease of the small bowel: report of a case. Dis Colon Rectum. 1998;41:1581–4.

    Article  PubMed  CAS  Google Scholar 

  12. Hendrickx L, Van Wijngaerden E, Samson I, Peetermans WE. Candidal vertebral osteomyelitis: report of 6 patients, and a review. Clin Infect Dis. 2001;32:527–33.

    Article  PubMed  CAS  Google Scholar 

  13. Pappas PG, Kauffman CA, Andes D, Benjamin DK Jr, Calandra TF, Edwards JE Jr, Filler SG, Fisher JF, Kullberg BJ, Ostrosky-Zeichner L, Reboli AC, Rex JH, Walsh TJ, Sobel JD; Infectious Diseases Society of America. Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America. Clin Infect Dis. 2009;48:503–35.

    Article  PubMed  CAS  Google Scholar 

  14. Sica G, Meissner S, Dawas K, Maynard N. Candida osteo-chondromyelitis complicating thoraco-abdominal esophageal surgery. Surg Infect (Larchmt). 2007;8:479–82.

    Article  Google Scholar 

  15. Rodríguez D, Pigrau C, Almirante B, Gasser I, Ruiz I, Pahissa A. Vertebral osteomyelitis due to Candida spp. Enferm Infecc Microbiol Clin. 2003;21:568–70.

    Article  PubMed  Google Scholar 

  16. Imhof A, Schaer C, Schoedon G, Schaer DJ, Walter RB, Schaffner A, Schneemann M. Rapid detection of pathogenic fungi from clinical specimens using LightCycler real-time fluorescence PCR. Eur J Clin Microbiol Infect Dis. 2003;22:558–60.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

We thank José María Bondía and Dámaso Aquerreta for contributing to the illustrations and Dr. Paul Miller for the English language revision.

Conflict of interest

The authors certify that there is no actual or potential conflict of interest in relation to this article.

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Authors and Affiliations

  1. Division of Infectious Diseases, Clinica Universidad de Navarra, Pamplona, Spain

    J. R. Yuste, C. Bustos, J. Quintana & J. L. Del Pozo

  2. Department of Orthopedic Surgery, Clinica Universidad de Navarra, Pamplona, Spain

    M. Alfonso & C. Villas

  3. Department of Clinical Microbiology, Clinica Universidad de Navarra, Pamplona, Spain

    M. Rubio

Authors
  1. J. R. Yuste
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  2. M. Alfonso
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  3. C. Bustos
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  4. J. Quintana
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  5. M. Rubio
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  6. C. Villas
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  7. J. L. Del Pozo
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Corresponding author

Correspondence to J. R. Yuste.

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Yuste, J.R., Alfonso, M., Bustos, C. et al. Iliac bone Candida albicans osteomyelitis in a patient with iliac crest bone autograft: a case report and review of the literature. Infection 40, 445–449 (2012). https://doi.org/10.1007/s15010-012-0276-z

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  • DOI: https://doi.org/10.1007/s15010-012-0276-z

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