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Urine Interleukin-8 Is a Marker for Urinary Tract Infection in Postoperative Patients

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Abstract

Background: Urine of patients with urinary tract infection (UTI) contains high levels of interleukin (IL)-6 and IL-8. However, knowledge of the kinetics of their release in urine is limited. We therefore compared the appearance of IL-6 and IL-8 in urine after uncomplicated surgery and surgery complicated by UTI.

Patients and Methods: 165 patients undergoing abdominal surgery who received a urinary catheter were studied. Urine IL-6 and IL-8 were prospectively measured in patients who did (n = 10) or did not (n = 20) develop UTI. Statistical analysis was done by one-way ANOVA and the Mann-Whitney test.

Results: Although urine IL-6 increased in the 2 to 4 days preceding the bacteriological documentation of UTI, a similar increase was observed in patients who did not develop UTI. Urine IL-8 was elevated on the day UTI was diagnosed, while remaining low in controls.

Conclusion: In this patient group with postoperative UTI, urine IL-8 was a better marker for the early host response than urine IL-6.

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Authors and Affiliations

  1. Dept. of Experimental Internal Medicine, Academic Medical Center, Room G2-132, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands; Phone: (+31/20)-5669111, Fax: -6977192, e-mail: t.vanderpoll@amc.uva.nl, , , , , , NL

    D.P. Olszyna, S.J.H. van Deventer & T. van der Poll

  2. Dept. of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, Amsterdam, The Netherlands, , , , , , NL

    P. Speelman

  3. Dept. of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands, , , , , , NL

    H. Vermeulen & D.J. Gouma

Authors
  1. D.P. Olszyna
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  2. H. Vermeulen
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  3. A.H. Baan
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  4. P. Speelman
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  5. S.J.H. van Deventer
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  6. D.J. Gouma
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  7. T. van der Poll
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Received: October 5, 2000 · Revision accepted: July 14, 2001

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Olszyna, D., Vermeulen, H., Baan, A. et al. Urine Interleukin-8 Is a Marker for Urinary Tract Infection in Postoperative Patients. Infection 29, 274–277 (2001). https://doi.org/10.1007/s15010-001-1157-z

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  • DOI: https://doi.org/10.1007/s15010-001-1157-z

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