Skip to main content
Erschienen in: Allergo Journal 7/2022

31.10.2022 | COVID-19 | Übersicht

Störungen des Riech- und Schmeckvermögens bei COVID-19

verfasst von: Prof. Dr. med. Ludger Klimek, Dr. med. Jan Hagemann, Julia Döge, Laura Koll, PD Dr. med. Mandy Cuevas, Felix Klimek, Thomas Hummel

Erschienen in: Allergo Journal | Ausgabe 7/2022

Einloggen, um Zugang zu erhalten

Zusammenfassung

Der Verlust des Riechvermögens ist eines der Symptome, die von Patienten mit COVID-19 mit am häufigsten angegeben werden. Obwohl die Spontanheilungsrate hoch ist, haben neuere Studien gezeigt, dass bis zu 7 % der Patienten mehr als zwölf Monate nach Beginn der Infektion anosmisch bleiben, sodass weltweit Millionen von Menschen unter schweren Riechstörungen leiden. Riechtraining ist nach wie vor die erste empfohlene Behandlungsform. Angesichts weiterhin fehlender zugelassener medikamentöser Behandlungsmöglichkeiten werden neue therapeutische Optionen erforscht.
Dieser Artikel gibt einen Überblick über den aktuellen Stand der Wissenschaft zu COVID-19-bedingten Riechstörungen, wobei der Schwerpunkt auf der Epidemiologie, der Pathophysiologie, den Heilungsraten, den derzeit verfügbaren Behandlungsmöglichkeiten und der Forschung zu neuen Behandlungsmethoden liegt.
Zitierweise: Klimek L, Hagemann J, Döge J, Freudelsperger L, Cuevas M, Klimek F, Hummel T. Olfactory and gustatory disorders in COVID-19. Allergo J Int 2022;31:243-50
Literatur
1.
Zurück zum Zitat Damm M, Schmitl L, Müller CA, Welge-Lüssen A, Hummel T. Diagnostik und Therapie von Riechstörungen. HNO 2019;67:274-81 Damm M, Schmitl L, Müller CA, Welge-Lüssen A, Hummel T. Diagnostik und Therapie von Riechstörungen. HNO 2019;67:274-81
2.
Zurück zum Zitat Klimek L, Eggers G. Olfactory dysfunction in allergic rhinitis is related to nasal eosinophilic inflammation. J Allergy Clin Immun 1997;100:158-64 Klimek L, Eggers G. Olfactory dysfunction in allergic rhinitis is related to nasal eosinophilic inflammation. J Allergy Clin Immun 1997;100:158-64
3.
Zurück zum Zitat Klimek L, Jutel M, Bousquet J, Agache I, Akdis CA, Hox V et al. Management of patients with chronic rhinosinusitis during the COVID-19 pandemic - An EAACI position paper. Allergy 2021;76:677-88 Klimek L, Jutel M, Bousquet J, Agache I, Akdis CA, Hox V et al. Management of patients with chronic rhinosinusitis during the COVID-19 pandemic - An EAACI position paper. Allergy 2021;76:677-88
4.
Zurück zum Zitat Moll B, Klimek L, Eggers G, Mann W. Comparison of olfactory function in patients with seasonal and perennial allergic rhinitis. Allergy 1998;53:297-301 Moll B, Klimek L, Eggers G, Mann W. Comparison of olfactory function in patients with seasonal and perennial allergic rhinitis. Allergy 1998;53:297-301
5.
Zurück zum Zitat Seiden AM. Postviral olfactory loss. Otolaryngol Clin North Am 2004;37:1159-66 Seiden AM. Postviral olfactory loss. Otolaryngol Clin North Am 2004;37:1159-66
6.
Zurück zum Zitat Welge-Lüssen A, Wolfensberger M. Olfactory disorders following upper respiratory tract infections. Adv Otorhinolaryngol 2005;63:125-32 Welge-Lüssen A, Wolfensberger M. Olfactory disorders following upper respiratory tract infections. Adv Otorhinolaryngol 2005;63:125-32
7.
Zurück zum Zitat Klimek L, Bergmann K-C, Brehler R, Pfützner W, Zuberbier T, Hartmann K et al. Practical handling of allergic reactions to COVID-19 vaccines: A position paper from German and Austrian Allergy Societies AeDA, DGAKI, GPA and ÖGAI. Allergo J Int 2021;30:1-17 Klimek L, Bergmann K-C, Brehler R, Pfützner W, Zuberbier T, Hartmann K et al. Practical handling of allergic reactions to COVID-19 vaccines: A position paper from German and Austrian Allergy Societies AeDA, DGAKI, GPA and ÖGAI. Allergo J Int 2021;30:1-17
8.
Zurück zum Zitat Klimek L, Novak N, Hamelmann E, Werfel T, Wagenmann M, Taube C et al. Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA. Allergo J Int 2021;30:51-5 Klimek L, Novak N, Hamelmann E, Werfel T, Wagenmann M, Taube C et al. Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA. Allergo J Int 2021;30:51-5
9.
Zurück zum Zitat Klimek L, Worm M, Lange L, Beyer K, Rietschel E, Vogelberg C et al. Management von Anaphylaxiegefährdeten Patienten während der Covid-19-Pandemie. Allergo J 2020; 29:16-26 Klimek L, Worm M, Lange L, Beyer K, Rietschel E, Vogelberg C et al. Management von Anaphylaxiegefährdeten Patienten während der Covid-19-Pandemie. Allergo J 2020; 29:16-26
10.
Zurück zum Zitat Untersmayr E, Förster-Waldl E, Bonelli M, Boztug K, Brunner PM, Eiwegger T et al. Immunologically relevant aspects of the new COVID-19 vaccines-an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper. Allergo J Int 2021:1-14 Untersmayr E, Förster-Waldl E, Bonelli M, Boztug K, Brunner PM, Eiwegger T et al. Immunologically relevant aspects of the new COVID-19 vaccines-an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper. Allergo J Int 2021:1-14
11.
Zurück zum Zitat Hopkins C, Surda P, Kumar N. Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology 2020;58:295-8 Hopkins C, Surda P, Kumar N. Presentation of new onset anosmia during the COVID-19 pandemic. Rhinology 2020;58:295-8
12.
Zurück zum Zitat Borsetto D, Hopkins C, Philips V, Obholzer R, Tirelli G, Polesel J et al. Self-reported alteration of sense of smell or taste in patients with COVID-19: a systematic review and meta-analysis on 3563 patients. Rhinology 2020;58:430-6 Borsetto D, Hopkins C, Philips V, Obholzer R, Tirelli G, Polesel J et al. Self-reported alteration of sense of smell or taste in patients with COVID-19: a systematic review and meta-analysis on 3563 patients. Rhinology 2020;58:430-6
13.
Zurück zum Zitat Mao L, Jin H, Wang M, Hu Y, Chen S, He Q et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683-90 Mao L, Jin H, Wang M, Hu Y, Chen S, He Q et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683-90
14.
Zurück zum Zitat Yan CH, Faraji F, Prajapati DP, Ostrander BT, DeConde AS. Self-reported olfactory loss associates with outpatient clinical course in COVID-19. Int Forum Allergy Rhinol 2020;10:821-31 Yan CH, Faraji F, Prajapati DP, Ostrander BT, DeConde AS. Self-reported olfactory loss associates with outpatient clinical course in COVID-19. Int Forum Allergy Rhinol 2020;10:821-31
15.
Zurück zum Zitat Lechien JR, Michel J, Radulesco T, Chiesa-Estomba CM, Vaira LA, De Riu G et al. Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report. Laryngoscope 2020;130:2526-31 Lechien JR, Michel J, Radulesco T, Chiesa-Estomba CM, Vaira LA, De Riu G et al. Clinical and Radiological Evaluations of COVID-19 Patients With Anosmia: Preliminary Report. Laryngoscope 2020;130:2526-31
16.
Zurück zum Zitat Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol 2020;10:944-50 Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol 2020;10:944-50
17.
Zurück zum Zitat Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Chiesa-Estomba CM, Salzano G et al. Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study. J Laryngol Otol 2020;134:703-9 Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Chiesa-Estomba CM, Salzano G et al. Smell and taste recovery in coronavirus disease 2019 patients: a 60-day objective and prospective study. J Laryngol Otol 2020;134:703-9
18.
Zurück zum Zitat von Bartheld CS, Hagen MM, Butowt R. Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences. ACS chemical neuroscience 2020;11:2944-61 von Bartheld CS, Hagen MM, Butowt R. Prevalence of Chemosensory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis Reveals Significant Ethnic Differences. ACS chemical neuroscience 2020;11:2944-61
19.
Zurück zum Zitat Yoon HE, Kim EN, Kim MY, Lim JH, Jang I-A, Ban TH et al. Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. Oxidative medicine and cellular longevity 2016;2016:6731093 Yoon HE, Kim EN, Kim MY, Lim JH, Jang I-A, Ban TH et al. Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice. Oxidative medicine and cellular longevity 2016;2016:6731093
20.
Zurück zum Zitat Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C et al. Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. JAMA 2020;323:2089 Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C et al. Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. JAMA 2020;323:2089
21.
Zurück zum Zitat Klopfenstein T, Kadiane-Oussou NJ, Toko L, Royer PY, Lepiller Q, Gendrin V et al. Features of anosmia in COVID-19. Med Mal Infect 2020;50:436-9 Klopfenstein T, Kadiane-Oussou NJ, Toko L, Royer PY, Lepiller Q, Gendrin V et al. Features of anosmia in COVID-19. Med Mal Infect 2020;50:436-9
22.
Zurück zum Zitat Huart C, Philpott C, Konstantinidis I, Altundag A, Whitcroft KL, Trecca EMC et al. Comparison of COVID-19 and common cold chemosensory dysfunction. Rhinology 2020;58:623-5 Huart C, Philpott C, Konstantinidis I, Altundag A, Whitcroft KL, Trecca EMC et al. Comparison of COVID-19 and common cold chemosensory dysfunction. Rhinology 2020;58:623-5
23.
Zurück zum Zitat Chowdhury S, Bappy MH, Chowdhury S, Chowdhury MS, Chowdhury NS. Current Review of Delta Variant of SARS-CoV-2. EJMED 2021;3:23-9 Chowdhury S, Bappy MH, Chowdhury S, Chowdhury MS, Chowdhury NS. Current Review of Delta Variant of SARS-CoV-2. EJMED 2021;3:23-9
24.
Zurück zum Zitat Soh SHL, See A, Teo NWY, Tan HK, Palaniappan G, Lim MLA et al. Prevalence of olfactory and taste dysfunction in COVID-19 patients: a community care facility study. Eur Arch Otorhinolaryngol 2021;278:3375-80 Soh SHL, See A, Teo NWY, Tan HK, Palaniappan G, Lim MLA et al. Prevalence of olfactory and taste dysfunction in COVID-19 patients: a community care facility study. Eur Arch Otorhinolaryngol 2021;278:3375-80
25.
Zurück zum Zitat Thakur K, Sagayaraj A, Prasad KC, Gupta A. Olfactory Dysfunction in COVID-19 Patients: Findings from a Tertiary Rural Centre. Indian J Otolaryngol Head Neck Surg 2021:18;1-7 Thakur K, Sagayaraj A, Prasad KC, Gupta A. Olfactory Dysfunction in COVID-19 Patients: Findings from a Tertiary Rural Centre. Indian J Otolaryngol Head Neck Surg 2021:18;1-7
26.
Zurück zum Zitat Hu Z, Huang X, Zhang J, Fu S, Ding D, Tao Z. Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients. Front Med 2022;8:792135 Hu Z, Huang X, Zhang J, Fu S, Ding D, Tao Z. Differences in Clinical Characteristics Between Delta Variant and Wild-Type SARS-CoV-2 Infected Patients. Front Med 2022;8:792135
27.
Zurück zum Zitat Smith P, Lesslar O, Price D, Ming L. Correspondence to "Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold: An ARIA-EAACI-GA2LEN consensus". Allergy 2022; in press Smith P, Lesslar O, Price D, Ming L. Correspondence to "Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold: An ARIA-EAACI-GA2LEN consensus". Allergy 2022; in press
28.
Zurück zum Zitat Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Soma D, Giovanditto F et al. Do olfactory and gustatory psychophysical scores have prognostic value in COVID-19 patients? A prospective study of 106 patients. J Otolaryngol Head Neck Surg 2020;49:56 Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Soma D, Giovanditto F et al. Do olfactory and gustatory psychophysical scores have prognostic value in COVID-19 patients? A prospective study of 106 patients. J Otolaryngol Head Neck Surg 2020;49:56
29.
Zurück zum Zitat Vaira LA, Deiana G, Lechien JR, De Vito A, Cossu A, Dettori M et al. Correlations Between Olfactory Psychophysical Scores and SARS-CoV-2 Viral Load in COVID-19 Patients. Laryngoscope 2021;131:2312-8 Vaira LA, Deiana G, Lechien JR, De Vito A, Cossu A, Dettori M et al. Correlations Between Olfactory Psychophysical Scores and SARS-CoV-2 Viral Load in COVID-19 Patients. Laryngoscope 2021;131:2312-8
30.
Zurück zum Zitat Amadu AM, Vaira LA, Lechien JR, Scaglione M, Saba L, Lampus ML et al. Analysis of the correlations between the severity of lung involvement and olfactory psychophysical scores in coronavirus disease 2019 (COVID-19) patients. Int Forum Allergy Rhinol 2021;12:103-7 Amadu AM, Vaira LA, Lechien JR, Scaglione M, Saba L, Lampus ML et al. Analysis of the correlations between the severity of lung involvement and olfactory psychophysical scores in coronavirus disease 2019 (COVID-19) patients. Int Forum Allergy Rhinol 2021;12:103-7
31.
Zurück zum Zitat Khan M, Yoo SJ, Clijsters M, Backaert W, Vanstapel A, Speleman K et al. Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb. Cell 2021;184:5932-49.e15 Khan M, Yoo SJ, Clijsters M, Backaert W, Vanstapel A, Speleman K et al. Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb. Cell 2021;184:5932-49.e15
32.
Zurück zum Zitat Lee JC, Nallani R, Cass L, Bhalla V, Chiu AG, Villwock JA. A Systematic Review of the Neuropathologic Findings of Post-Viral Olfactory Dysfunction: Implications and Novel Insight for the COVID-19 Pandemic. Am J Rhinol Allergy 2020;35:323-33 Lee JC, Nallani R, Cass L, Bhalla V, Chiu AG, Villwock JA. A Systematic Review of the Neuropathologic Findings of Post-Viral Olfactory Dysfunction: Implications and Novel Insight for the COVID-19 Pandemic. Am J Rhinol Allergy 2020;35:323-33
33.
Zurück zum Zitat Brann DH, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv 2020;6:eabc5801 Brann DH, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B et al. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv 2020;6:eabc5801
34.
Zurück zum Zitat Butowt R, Meunier N, Bryche B, von Bartheld CS. The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models. Acta Neuropathol 2021;141:809-22 Butowt R, Meunier N, Bryche B, von Bartheld CS. The olfactory nerve is not a likely route to brain infection in COVID-19: a critical review of data from humans and animal models. Acta Neuropathol 2021;141:809-22
35.
Zurück zum Zitat Akerlund A, Bende M, Murphy C. Olfactory threshold and nasal mucosal changes in experimentally induced common cold. Acta Otolaryngol 1995;115:88-92 Akerlund A, Bende M, Murphy C. Olfactory threshold and nasal mucosal changes in experimentally induced common cold. Acta Otolaryngol 1995;115:88-92
36.
Zurück zum Zitat Hagemann J, Onorato GL, Jutel M, Akdis CA, Agache I, Zuberbier T et al. Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold: An ARIA-EAACI-GA2LEN consensus. Allergy 2021;76:2354-66 Hagemann J, Onorato GL, Jutel M, Akdis CA, Agache I, Zuberbier T et al. Differentiation of COVID-19 signs and symptoms from allergic rhinitis and common cold: An ARIA-EAACI-GA2LEN consensus. Allergy 2021;76:2354-66
37.
Zurück zum Zitat Eliezer M, Hamel A-L, Houdart E, Herman P, Housset J, Jourdaine C et al. Loss of smell in patients with COVID-19: MRI data reveal a transient edema of the olfactory clefts. Neurology 2020;95:e3145-e52 Eliezer M, Hamel A-L, Houdart E, Herman P, Housset J, Jourdaine C et al. Loss of smell in patients with COVID-19: MRI data reveal a transient edema of the olfactory clefts. Neurology 2020;95:e3145-e52
38.
Zurück zum Zitat Yamagishi M, Hasegawa S, Nakano Y. Examination and classification of human olfactory mucosa in patients with clinical olfactory disturbances. Arch Otorhinolaryngol 1988;245:316-20 Yamagishi M, Hasegawa S, Nakano Y. Examination and classification of human olfactory mucosa in patients with clinical olfactory disturbances. Arch Otorhinolaryngol 1988;245:316-20
39.
Zurück zum Zitat Kirschenbaum D, Imbach LL, Ulrich S, Rushing EJ, Keller E, Reimann RR et al. Inflammatory olfactory neuropathy in two patients with COVID-19. Lancet (London, England) 2020;396:166 Kirschenbaum D, Imbach LL, Ulrich S, Rushing EJ, Keller E, Reimann RR et al. Inflammatory olfactory neuropathy in two patients with COVID-19. Lancet (London, England) 2020;396:166
40.
Zurück zum Zitat Bryche B, St Albin A, Murri S, Lacôte S, Pulido C, Ar Gouilh M et al. Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters. Brain Behav Immun 2020;89:579-86 Bryche B, St Albin A, Murri S, Lacôte S, Pulido C, Ar Gouilh M et al. Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters. Brain Behav Immun 2020;89:579-86
41.
Zurück zum Zitat Bilinska K, Jakubowska P, Von Bartheld CS, Butowt R. Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. ACS Chem Neurosci 2020;11:1555-62 Bilinska K, Jakubowska P, Von Bartheld CS, Butowt R. Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age. ACS Chem Neurosci 2020;11:1555-62
42.
Zurück zum Zitat Karamali K, Elliott M, Hopkins C. COVID-19 related olfactory dysfunction. Current Opin Otolaryngol Head Neck Surg 2021;30:19-25 Karamali K, Elliott M, Hopkins C. COVID-19 related olfactory dysfunction. Current Opin Otolaryngol Head Neck Surg 2021;30:19-25
43.
Zurück zum Zitat de Melo GD, Lazarini F, Levallois S, Hautefort C, Michel V, Larrous F et al. COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters. Sci Transl Med 2021;13 de Melo GD, Lazarini F, Levallois S, Hautefort C, Michel V, Larrous F et al. COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters. Sci Transl Med 2021;13
44.
Zurück zum Zitat Chen M, Reed RR, Lane AP. Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense. Cell Stem Cell 2019;25:501-13.e5 Chen M, Reed RR, Lane AP. Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense. Cell Stem Cell 2019;25:501-13.e5
45.
Zurück zum Zitat Lechien JR, Hopkins C, Vaira LA, Saussez S. SARS-CoV-2 vaccination may help patients with persistent COVID-19 smell dysfunction. Ear Nose Throat J 2021:1455613211044770 Lechien JR, Hopkins C, Vaira LA, Saussez S. SARS-CoV-2 vaccination may help patients with persistent COVID-19 smell dysfunction. Ear Nose Throat J 2021:1455613211044770
46.
Zurück zum Zitat Dubé M, Le Coupanec A, Wong AHM, Rini JM, Desforges M, Talbot PJ. Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43. J Virol 2018;92:e00404-18 Dubé M, Le Coupanec A, Wong AHM, Rini JM, Desforges M, Talbot PJ. Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43. J Virol 2018;92:e00404-18
47.
Zurück zum Zitat Perlman S, Jacobsen G, Afifi A. Spread of a neurotropic murine coronavirus into the CNS via the trigeminal and olfactory nerves. Virology 1989;170:556-60 Perlman S, Jacobsen G, Afifi A. Spread of a neurotropic murine coronavirus into the CNS via the trigeminal and olfactory nerves. Virology 1989;170:556-60
48.
Zurück zum Zitat McCray PB, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol 2006;81:813-21 McCray PB, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L et al. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J Virol 2006;81:813-21
49.
Zurück zum Zitat Aragão MFVV, Leal MC, Cartaxo Filho OQ, Fonseca TM, Valença MM. Anosmia in COVID-19 Associated with Injury to the Olfactory Bulbs Evident on MRI. AJNR Am J Neuroradiol 2020;41:1703-6 Aragão MFVV, Leal MC, Cartaxo Filho OQ, Fonseca TM, Valença MM. Anosmia in COVID-19 Associated with Injury to the Olfactory Bulbs Evident on MRI. AJNR Am J Neuroradiol 2020;41:1703-6
50.
Zurück zum Zitat Laurendon T, Radulesco T, Mugnier J, Gérault M, Chagnaud C, El Ahmadi A-A et al. Bilateral transient olfactory bulb edema during COVID-19-related anosmia. Neurology 2020;95:224-5 Laurendon T, Radulesco T, Mugnier J, Gérault M, Chagnaud C, El Ahmadi A-A et al. Bilateral transient olfactory bulb edema during COVID-19-related anosmia. Neurology 2020;95:224-5
51.
Zurück zum Zitat Politi LS, Salsano E, Grimaldi M. Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia. JAMA Neurol 2020;77:1028-9 Politi LS, Salsano E, Grimaldi M. Magnetic Resonance Imaging Alteration of the Brain in a Patient With Coronavirus Disease 2019 (COVID-19) and Anosmia. JAMA Neurol 2020;77:1028-9
52.
Zurück zum Zitat Klironomos S, Tzortzakakis A, Kits A, Öhberg C, Kollia E, Ahoromazdae A et al. Nervous System Involvement in Coronavirus Disease 2019: Results from a Retrospective Consecutive Neuroimaging Cohort. Radiology 2020;297:E324-E34 Klironomos S, Tzortzakakis A, Kits A, Öhberg C, Kollia E, Ahoromazdae A et al. Nervous System Involvement in Coronavirus Disease 2019: Results from a Retrospective Consecutive Neuroimaging Cohort. Radiology 2020;297:E324-E34
53.
Zurück zum Zitat Chiu A, Fischbein N, Wintermark M, Zaharchuk G, Yun PT, Zeineh M. COVID-19-induced anosmia associated with olfactory bulb atrophy. Neuroradiology 2020;63:147-8 Chiu A, Fischbein N, Wintermark M, Zaharchuk G, Yun PT, Zeineh M. COVID-19-induced anosmia associated with olfactory bulb atrophy. Neuroradiology 2020;63:147-8
54.
Zurück zum Zitat Guedj E, Million M, Dudouet P, Tissot-Dupont H, Bregeon F, Cammilleri S et al. (18)F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders? Eur J Nucl Med Mol Imaging 2021;48:592-5 Guedj E, Million M, Dudouet P, Tissot-Dupont H, Bregeon F, Cammilleri S et al. (18)F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders? Eur J Nucl Med Mol Imaging 2021;48:592-5
55.
Zurück zum Zitat Altrichter S, Wöhrl S, Horak F, Idzko M, Jordakieva G, Untersmayr E et al. Answers to burning questions for clinical allergologists related to the new COVID-19 vaccines. Allergo J Int 2021;30:169-75 Altrichter S, Wöhrl S, Horak F, Idzko M, Jordakieva G, Untersmayr E et al. Answers to burning questions for clinical allergologists related to the new COVID-19 vaccines. Allergo J Int 2021;30:169-75
56.
Zurück zum Zitat Bergmann K-C, Kugler S, Zuberbier T, Becker S. Face masks suitable for preventing COVID-19 and pollen allergy. A study in the exposure chamber. Allergo J Int 2021;30:176-82 Bergmann K-C, Kugler S, Zuberbier T, Becker S. Face masks suitable for preventing COVID-19 and pollen allergy. A study in the exposure chamber. Allergo J Int 2021;30:176-82
57.
Zurück zum Zitat Dramburg S, Matricardi PM, Casper I, Klimek L. Use of telemedicine by practising allergists before and during the SARS-CoV-2 pandemic: A survey among members of the Association of German Allergists (AeDA). Allergo J Int 2021;30:193-97 Dramburg S, Matricardi PM, Casper I, Klimek L. Use of telemedicine by practising allergists before and during the SARS-CoV-2 pandemic: A survey among members of the Association of German Allergists (AeDA). Allergo J Int 2021;30:193-97
58.
Zurück zum Zitat Dramburg S, Walter U, Becker S, Casper I, Röseler S, Schareina A et al. Telemedicine in allergology: practical aspects: A position paper of the Association of German Allergists (AeDA). Allergo J Int 2021:1-11 Dramburg S, Walter U, Becker S, Casper I, Röseler S, Schareina A et al. Telemedicine in allergology: practical aspects: A position paper of the Association of German Allergists (AeDA). Allergo J Int 2021:1-11
59.
Zurück zum Zitat Klimek L, Hagemann J, Alali A, Spielhaupter M, Huppertz T, Hörmann K et al. Telemedicine allows quantitative measuring of olfactory dysfunction in COVID-19. Allergy 2020;76:868-70 Klimek L, Hagemann J, Alali A, Spielhaupter M, Huppertz T, Hörmann K et al. Telemedicine allows quantitative measuring of olfactory dysfunction in COVID-19. Allergy 2020;76:868-70
60.
Zurück zum Zitat Hopkins C, Surda P, Whitehead E, Kumar BN. Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study. J Otolaryngol Head Neck Surg 2020;49:26 Hopkins C, Surda P, Whitehead E, Kumar BN. Early recovery following new onset anosmia during the COVID-19 pandemic - an observational cohort study. J Otolaryngol Head Neck Surg 2020;49:26
61.
Zurück zum Zitat Chiesa-Estomba CM, Lechien JR, Radulesco T, Michel J, Sowerby LJ, Hopkins C et al. Patterns of smell recovery in 751 patients affected by the COVID-19 outbreak. Eur J Neurol 2020;27:2318-21 Chiesa-Estomba CM, Lechien JR, Radulesco T, Michel J, Sowerby LJ, Hopkins C et al. Patterns of smell recovery in 751 patients affected by the COVID-19 outbreak. Eur J Neurol 2020;27:2318-21
62.
Zurück zum Zitat Boscolo-Rizzo P, Guida F, Polesel J, Marcuzzo AV, Antonucci P, Capriotti V et al. Self-reported smell and taste recovery in coronavirus disease 2019 patients: a one-year prospective study. Eur Arch Otorhinolaryngol 2021;279: 515-520 Boscolo-Rizzo P, Guida F, Polesel J, Marcuzzo AV, Antonucci P, Capriotti V et al. Self-reported smell and taste recovery in coronavirus disease 2019 patients: a one-year prospective study. Eur Arch Otorhinolaryngol 2021;279: 515-520
63.
Zurück zum Zitat Hopkins C, Surda P, Vaira LA, Lechien JR, Safarian M, Saussez S et al. Six month follow-up of self-reported loss of smell during the COVID-19 pandemic. Rhinology 2020;59:26-31 Hopkins C, Surda P, Vaira LA, Lechien JR, Safarian M, Saussez S et al. Six month follow-up of self-reported loss of smell during the COVID-19 pandemic. Rhinology 2020;59:26-31
64.
Zurück zum Zitat Lucidi D, Molinari G, Silvestri M, De Corso E, Guaraldi G, Mussini C et al. Patient-reported olfactory recovery after SARS-CoV-2 infection: A 6-month follow-up study. Int Forum Allergy Rhinol 2021;11:1249-52 Lucidi D, Molinari G, Silvestri M, De Corso E, Guaraldi G, Mussini C et al. Patient-reported olfactory recovery after SARS-CoV-2 infection: A 6-month follow-up study. Int Forum Allergy Rhinol 2021;11:1249-52
65.
Zurück zum Zitat Riestra-Ayora J, Yanes-Diaz J, Esteban-Sanchez J, Vaduva C, Molina-Quiros C, Larran-Jimenez A et al. Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case-control study of health workers. Eur Arch Otorhinolaryngol 2021;278:4831-7 Riestra-Ayora J, Yanes-Diaz J, Esteban-Sanchez J, Vaduva C, Molina-Quiros C, Larran-Jimenez A et al. Long-term follow-up of olfactory and gustatory dysfunction in COVID-19: 6 months case-control study of health workers. Eur Arch Otorhinolaryngol 2021;278:4831-7
66.
Zurück zum Zitat Leedman SR, Sheeraz M, Sanfilippo PG, Edgar DW, D'Aulerio GV, Robb DM et al. Olfactory dysfunction at six months after coronavirus disease 2019 infection. J Laryngol Otol 2021;135:839-43 Leedman SR, Sheeraz M, Sanfilippo PG, Edgar DW, D'Aulerio GV, Robb DM et al. Olfactory dysfunction at six months after coronavirus disease 2019 infection. J Laryngol Otol 2021;135:839-43
67.
Zurück zum Zitat Boscolo-Rizzo P, Hummel T, Hopkins C, Dibattista M, Menini A, Spinato G et al. High prevalence of long-term olfactory, gustatory, and chemesthesis dysfunction in post-COVID-19 patients: a matched case-control study with one-year follow-up using a comprehensive psychophysical evaluation. Rhinology 2021;59:517-27 Boscolo-Rizzo P, Hummel T, Hopkins C, Dibattista M, Menini A, Spinato G et al. High prevalence of long-term olfactory, gustatory, and chemesthesis dysfunction in post-COVID-19 patients: a matched case-control study with one-year follow-up using a comprehensive psychophysical evaluation. Rhinology 2021;59:517-27
68.
Zurück zum Zitat Duyan M, Ozturan IU, Altas M. Delayed Parosmia Following SARS-CoV-2 Infection: a Rare Late Complication of COVID-19. SN Compr Clin Med 2021:1-3 Duyan M, Ozturan IU, Altas M. Delayed Parosmia Following SARS-CoV-2 Infection: a Rare Late Complication of COVID-19. SN Compr Clin Med 2021:1-3
69.
Zurück zum Zitat Frasnelli J, Landis BN, Heilmann S, Hauswald B, Hüttenbrink KB, Lacroix JS et al. Clinical presentation of qualitative olfactory dysfunction. Eur Arch Otorhinolaryngol 2004;261:411-5 Frasnelli J, Landis BN, Heilmann S, Hauswald B, Hüttenbrink KB, Lacroix JS et al. Clinical presentation of qualitative olfactory dysfunction. Eur Arch Otorhinolaryngol 2004;261:411-5
70.
Zurück zum Zitat Hong S-C, Holbrook EH, Leopold DA, Hummel T. Distorted olfactory perception: a systematic review. Acta Otolaryngol 2012;132 Suppl 1:S27-31 Hong S-C, Holbrook EH, Leopold DA, Hummel T. Distorted olfactory perception: a systematic review. Acta Otolaryngol 2012;132 Suppl 1:S27-31
71.
Zurück zum Zitat Burges Watson DL, Campbell M, Hopkins C, Smith B, Kelly C, Deary V. Altered smell and taste: Anosmia, parosmia and the impact of long Covid-19. PLoS One 2021;16:e0256998 Burges Watson DL, Campbell M, Hopkins C, Smith B, Kelly C, Deary V. Altered smell and taste: Anosmia, parosmia and the impact of long Covid-19. PLoS One 2021;16:e0256998
72.
Zurück zum Zitat Leopold D. Distortion of olfactory perception: diagnosis and treatment. Chem Senses 2002;27:611-5 Leopold D. Distortion of olfactory perception: diagnosis and treatment. Chem Senses 2002;27:611-5
73.
Zurück zum Zitat Murai A, Iwata R, Fujimoto S, Aihara S, Tsuboi A, Muroyama Y et al. Distorted Coarse Axon Targeting and Reduced Dendrite Connectivity Underlie Dysosmia after Olfactory Axon Injury. eNeuro 2016;3:ENEURO.0242- 16.2016 Murai A, Iwata R, Fujimoto S, Aihara S, Tsuboi A, Muroyama Y et al. Distorted Coarse Axon Targeting and Reduced Dendrite Connectivity Underlie Dysosmia after Olfactory Axon Injury. eNeuro 2016;3:ENEURO.0242- 16.2016
74.
Zurück zum Zitat Hawkes C. Parosmia: treatment, mechanism, and types. BMJ 2020;371:m4739 Hawkes C. Parosmia: treatment, mechanism, and types. BMJ 2020;371:m4739
75.
Zurück zum Zitat Holbrook EH, Leopold DA, Schwob JE. Abnormalities of axon growth in human olfactory mucosa. Laryngoscope 2005;115:2144-54 Holbrook EH, Leopold DA, Schwob JE. Abnormalities of axon growth in human olfactory mucosa. Laryngoscope 2005;115:2144-54
76.
Zurück zum Zitat Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T. Olfactory function and olfactory bulb volume in patients with postinfectious olfactory loss. Laryngoscope 2006;116:436-9 Rombaux P, Mouraux A, Bertrand B, Nicolas G, Duprez T, Hummel T. Olfactory function and olfactory bulb volume in patients with postinfectious olfactory loss. Laryngoscope 2006;116:436-9
77.
Zurück zum Zitat Iannilli E, Leopold DA, Hornung DE, Hummel T. Advances in Understanding Parosmia: An fMRI Study. ORL 2019;81:185-92 Iannilli E, Leopold DA, Hornung DE, Hummel T. Advances in Understanding Parosmia: An fMRI Study. ORL 2019;81:185-92
78.
Zurück zum Zitat Liu DT, Pellegrino R, Sabha M, Aytug A, Aytug A, Damm M et al. Factors associated with relevant olfactory recovery after olfactory training: a retrospective study including 601 participants. Rhinology 2021;59:91-7 Liu DT, Pellegrino R, Sabha M, Aytug A, Aytug A, Damm M et al. Factors associated with relevant olfactory recovery after olfactory training: a retrospective study including 601 participants. Rhinology 2021;59:91-7
79.
Zurück zum Zitat Reden J, Maroldt H, Fritz A, Zahnert T, Hummel T. A study on the prognostic significance of qualitative olfactory dysfunction. Eur Arch Otorhinolaryngol 2007;264:139-44 Reden J, Maroldt H, Fritz A, Zahnert T, Hummel T. A study on the prognostic significance of qualitative olfactory dysfunction. Eur Arch Otorhinolaryngol 2007;264:139-44
80.
Zurück zum Zitat Cook E, Kelly CE, Burges Watson DL, Hopkins C. Parosmia is prevalent and persistent amongst those with COVID-19 olfactory dysfunction. Rhinology 2020;59:222-4 Cook E, Kelly CE, Burges Watson DL, Hopkins C. Parosmia is prevalent and persistent amongst those with COVID-19 olfactory dysfunction. Rhinology 2020;59:222-4
81.
Zurück zum Zitat Saniasiaya J, Islam MA, Abdullah B. Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID-19): A Meta-analysis of 27,492 Patients. Laryngoscope 2020;131:865-78 Saniasiaya J, Islam MA, Abdullah B. Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID-19): A Meta-analysis of 27,492 Patients. Laryngoscope 2020;131:865-78
82.
Zurück zum Zitat Negoias S, Meves B, Zang Y, Haehner A, Hummel T. Characteristics of Olfactory Disorder With and Without Reported Flavor Loss. Laryngoscope 2020;130:2869-73 Negoias S, Meves B, Zang Y, Haehner A, Hummel T. Characteristics of Olfactory Disorder With and Without Reported Flavor Loss. Laryngoscope 2020;130:2869-73
83.
Zurück zum Zitat Rozin P. "Taste-smell confusions" and the duality of the olfactory sense. Percept Psychophys 1982;31:397-401 Rozin P. "Taste-smell confusions" and the duality of the olfactory sense. Percept Psychophys 1982;31:397-401
84.
Zurück zum Zitat Le Bon S-D, Payen L, Prunier L, Steffens Y, Horoi M, Vaira LA et al. Making scents of loss of taste in COVID-19: Is self-reported loss of taste due to olfactory dysfunction? A prospective study using psychophysical testing. Int Forum Allergy Rhinol 2021;11:1504-7 Le Bon S-D, Payen L, Prunier L, Steffens Y, Horoi M, Vaira LA et al. Making scents of loss of taste in COVID-19: Is self-reported loss of taste due to olfactory dysfunction? A prospective study using psychophysical testing. Int Forum Allergy Rhinol 2021;11:1504-7
85.
Zurück zum Zitat Singer-Cornelius T, Cornelius J, Oberle M, Metternich FU, Brockmeier SJ. Objective gustatory and olfactory dysfunction in COVID-19 patients: a prospective cross-sectional study. Eur Arch Otorhinolaryngol 2021;278:3325-32 Singer-Cornelius T, Cornelius J, Oberle M, Metternich FU, Brockmeier SJ. Objective gustatory and olfactory dysfunction in COVID-19 patients: a prospective cross-sectional study. Eur Arch Otorhinolaryngol 2021;278:3325-32
86.
Zurück zum Zitat Webster KE, O'Byrne L, MacKeith S, Philpott C, Hopkins C, Burton MJ. Interventions for the prevention of persistent post-COVID-19 olfactory dysfunction. Cochrane Database Syst Rev 2021;7:CD013877 Webster KE, O'Byrne L, MacKeith S, Philpott C, Hopkins C, Burton MJ. Interventions for the prevention of persistent post-COVID-19 olfactory dysfunction. Cochrane Database Syst Rev 2021;7:CD013877
87.
Zurück zum Zitat Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Cutrupi S, Salzano G et al. Efficacy of corticosteroid therapy in the treatment of long-lasting olfactory disorders in COVID-19 patients. Rhinology 2021;59:21-5 Vaira LA, Hopkins C, Petrocelli M, Lechien JR, Cutrupi S, Salzano G et al. Efficacy of corticosteroid therapy in the treatment of long-lasting olfactory disorders in COVID-19 patients. Rhinology 2021;59:21-5
88.
Zurück zum Zitat Yan CH, Overdevest JB, Patel ZM. Therapeutic use of steroids in non-chronic rhinosinusitis olfactory dysfunction: a systematic evidence-based review with recommendations. Int Forum Allergy Rhinol 2019;9:165-76 Yan CH, Overdevest JB, Patel ZM. Therapeutic use of steroids in non-chronic rhinosinusitis olfactory dysfunction: a systematic evidence-based review with recommendations. Int Forum Allergy Rhinol 2019;9:165-76
89.
Zurück zum Zitat Nguyen TP, Patel ZM. Budesonide irrigation with olfactory training improves outcomes compared with olfactory training alone in patients with olfactory loss. Int Forum Allergy Rhinol 2018; 8:977-81 Nguyen TP, Patel ZM. Budesonide irrigation with olfactory training improves outcomes compared with olfactory training alone in patients with olfactory loss. Int Forum Allergy Rhinol 2018; 8:977-81
90.
Zurück zum Zitat Benninger MS, Hadley JA, Osguthorpe JD, Marple BF, Leopold DA, Derebery MJ et al. Techniques of intranasal steroid use. Otolaryngol Head Neck Surg 2004;130:5-24 Benninger MS, Hadley JA, Osguthorpe JD, Marple BF, Leopold DA, Derebery MJ et al. Techniques of intranasal steroid use. Otolaryngol Head Neck Surg 2004;130:5-24
91.
Zurück zum Zitat Scheibe M, Bethge C, Witt M, Hummel T. Intranasal administration of drugs. Arch Otolaryngol Head Neck Surg 2008;134:643-6 Scheibe M, Bethge C, Witt M, Hummel T. Intranasal administration of drugs. Arch Otolaryngol Head Neck Surg 2008;134:643-6
92.
Zurück zum Zitat Harless L, Liang J. Pharmacologic treatment for postviral olfactory dysfunction: a systematic review. Int Forum Allergy Rhinol 2016;6:760-7 Harless L, Liang J. Pharmacologic treatment for postviral olfactory dysfunction: a systematic review. Int Forum Allergy Rhinol 2016;6:760-7
93.
Zurück zum Zitat Hopkins C, Alanin M, Philpott C, Harries P, Whitcroft K, Qureishi A et al. Management of new onset loss of sense of smell during the COVID-19 pandemic - BRS Consensus Guidelines. Clin Otolaryngol 2020;46:16-22 Hopkins C, Alanin M, Philpott C, Harries P, Whitcroft K, Qureishi A et al. Management of new onset loss of sense of smell during the COVID-19 pandemic - BRS Consensus Guidelines. Clin Otolaryngol 2020;46:16-22
94.
Zurück zum Zitat Huart C, Philpott CM, Altundag A, Fjaeldstad AW, Frasnelli J, Gane S et al. Systemic corticosteroids in coronavirus disease 2019 (COVID-19)-related smell dysfunction: an international view. Int Forum Allergy Rhinol 2021;11:1041-6 Huart C, Philpott CM, Altundag A, Fjaeldstad AW, Frasnelli J, Gane S et al. Systemic corticosteroids in coronavirus disease 2019 (COVID-19)-related smell dysfunction: an international view. Int Forum Allergy Rhinol 2021;11:1041-6
95.
Zurück zum Zitat Pekala K, Chandra RK, Turner JH. Efficacy of olfactory training in patients with olfactory loss: a systematic review and meta-analysis. Int Forum Allergy Rhinol 2016;6:299-307 Pekala K, Chandra RK, Turner JH. Efficacy of olfactory training in patients with olfactory loss: a systematic review and meta-analysis. Int Forum Allergy Rhinol 2016;6:299-307
96.
Zurück zum Zitat Sorokowska A, Drechsler E, Karwowski M, Hummel T. Effects of olfactory training: a meta-analysis. Rhinology 2017;55:17-26 Sorokowska A, Drechsler E, Karwowski M, Hummel T. Effects of olfactory training: a meta-analysis. Rhinology 2017;55:17-26
97.
Zurück zum Zitat Poletti SC, Michel E, Hummel T. Olfactory Training Using Heavy and Light Weight Molecule Odors. Perception 2017;46:343-51 Poletti SC, Michel E, Hummel T. Olfactory Training Using Heavy and Light Weight Molecule Odors. Perception 2017;46:343-51
98.
Zurück zum Zitat Damm M, Pikart LK, Reimann H, Burkert S, Göktas Ö, Haxel B et al. Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study. Laryngoscope 2014;124:826-31 Damm M, Pikart LK, Reimann H, Burkert S, Göktas Ö, Haxel B et al. Olfactory training is helpful in postinfectious olfactory loss: a randomized, controlled, multicenter study. Laryngoscope 2014;124:826-31
99.
Zurück zum Zitat Dorsch W, Ring J. Anti-inflammatory substances from onions could be an option for treatment of COVID-19-a hypothesis. Allergo J Int 2020;29:284-5 Dorsch W, Ring J. Anti-inflammatory substances from onions could be an option for treatment of COVID-19-a hypothesis. Allergo J Int 2020;29:284-5
100.
Zurück zum Zitat Yan CH, Mundy DC, Patel ZM. The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study. Laryngoscope Investig Otolaryngol 2020;5:187-93 Yan CH, Mundy DC, Patel ZM. The use of platelet-rich plasma in treatment of olfactory dysfunction: A pilot study. Laryngoscope Investig Otolaryngol 2020;5:187-93
101.
Zurück zum Zitat Dörig P, Gunder N, Witt M, Welge-Lüssen A, Hummel T. Zukunftsweisende Therapieansätze bei Riechstörungen: elektrische Stimulation, Stammzelltherapie und Transplantation von Riechepithel - eine Übersicht. HNO 2021;69:623-32 Dörig P, Gunder N, Witt M, Welge-Lüssen A, Hummel T. Zukunftsweisende Therapieansätze bei Riechstörungen: elektrische Stimulation, Stammzelltherapie und Transplantation von Riechepithel - eine Übersicht. HNO 2021;69:623-32
102.
Zurück zum Zitat Yagi S, Costanzo RM. Grafting the olfactory epithelium to the olfactory bulb. Am J Rhinol Allergy 2009;23:239-43 Yagi S, Costanzo RM. Grafting the olfactory epithelium to the olfactory bulb. Am J Rhinol Allergy 2009;23:239-43
103.
Zurück zum Zitat Kurtenbach S, Goss GM, Goncalves S, Choi R, Hare JM, Chaudhari N et al. Cell-Based Therapy Restores Olfactory Function in an Inducible Model of Hyposmia. Stem Cell Reports 2019;12:1354-65 Kurtenbach S, Goss GM, Goncalves S, Choi R, Hare JM, Chaudhari N et al. Cell-Based Therapy Restores Olfactory Function in an Inducible Model of Hyposmia. Stem Cell Reports 2019;12:1354-65
104.
Zurück zum Zitat Coelho DH, Costanzo RM. Spatial Mapping in the Rat Olfactory Bulb by Odor and Direct Electrical Stimulation. Otolaryngol Head Neck Surg 2016;155:526-32 Coelho DH, Costanzo RM. Spatial Mapping in the Rat Olfactory Bulb by Odor and Direct Electrical Stimulation. Otolaryngol Head Neck Surg 2016;155:526-32
105.
Zurück zum Zitat Holbrook EH, Puram SV, See RB, Tripp AG, Nair DG. Induction of smell through transethmoid electrical stimulation of the olfactory bulb. Int Forum Allergy Rhinol 2019;9:158-64 Holbrook EH, Puram SV, See RB, Tripp AG, Nair DG. Induction of smell through transethmoid electrical stimulation of the olfactory bulb. Int Forum Allergy Rhinol 2019;9:158-64
Metadaten
Titel
Störungen des Riech- und Schmeckvermögens bei COVID-19
verfasst von
Prof. Dr. med. Ludger Klimek
Dr. med. Jan Hagemann
Julia Döge
Laura Koll
PD Dr. med. Mandy Cuevas
Felix Klimek
Thomas Hummel
Publikationsdatum
31.10.2022
Verlag
Springer Medizin
Erschienen in
Allergo Journal / Ausgabe 7/2022
Print ISSN: 0941-8849
Elektronische ISSN: 2195-6405
DOI
https://doi.org/10.1007/s15007-022-5602-x

Weitere Artikel der Ausgabe 7/2022

Allergo Journal 7/2022 Zur Ausgabe

Die Verbände informieren

AeDA-Preisverleihungen 2022

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Betalaktam-Allergie: praxisnahes Vorgehen beim Delabeling

16.05.2024 Pädiatrische Allergologie Nachrichten

Die große Mehrheit der vermeintlichen Penicillinallergien sind keine. Da das „Etikett“ Betalaktam-Allergie oft schon in der Kindheit erworben wird, kann ein frühzeitiges Delabeling lebenslange Vorteile bringen. Ein Team von Pädiaterinnen und Pädiatern aus Kanada stellt vor, wie sie dabei vorgehen.

Klinikreform soll zehntausende Menschenleben retten

15.05.2024 Klinik aktuell Nachrichten

Gesundheitsminister Lauterbach hat die vom Bundeskabinett beschlossene Klinikreform verteidigt. Kritik an den Plänen kommt vom Marburger Bund. Und in den Ländern wird über den Gang zum Vermittlungsausschuss spekuliert.

Eingreifen von Umstehenden rettet vor Erstickungstod

15.05.2024 Fremdkörperaspiration Nachrichten

Wer sich an einem Essensrest verschluckt und um Luft ringt, benötigt vor allem rasche Hilfe. Dass Umstehende nur in jedem zweiten Erstickungsnotfall bereit waren, diese zu leisten, ist das ernüchternde Ergebnis einer Beobachtungsstudie aus Japan. Doch es gibt auch eine gute Nachricht.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.