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Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis

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Abstract

Response surface methodology (RSM) was utilized to optimize extraction conditions for the acetylcholinesterase inhibitor from Rhodiola sachalinensis. Optimized values for AChE inhibition and extraction yield were 19.41 and 13.35%, respectively, and these were in good agreement with the experimental values from validation, suggesting that RSM is a useful tool.

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Authors and Affiliations

  1. Department of Food and Biotechnology, Korea University, Seoul, 136-701, Republic of Korea

    Cho Rong Kim, Yoon Kyung Kwon & Dong-Hoon Shin

  2. Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, 55108, USA

    Jae Kyeom Kim

  3. Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, 660-758, Republic of Korea

    Eui-Cheol Shin

  4. Department of Food Technology, Korea University, Seoul, 136-701, Republic of Korea

    Soo Jung Choi

  5. Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC, 27695, USA

    Soo Jung Choi

  6. College of Nursing Science, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Youn-Jung Kim

  7. Department of Physiology, School of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Chang-Ju Kim

  8. Department of Food Science and Biotechnology, Gachon University, Seongnam, 461-701, Republic of Korea

    Gwi Gun Park

  9. Department of Microbiology, Kyunghee University, Seoul, 130-701, Republic of Korea

    Cheung-Seog Park

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  1. Cho Rong Kim
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  2. Jae Kyeom Kim
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  7. Chang-Ju Kim
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  8. Gwi Gun Park
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  9. Cheung-Seog Park
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  10. Dong-Hoon Shin
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Correspondence to Dong-Hoon Shin.

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Kim, C.R., Kim, J.K., Shin, EC. et al. Application of response surface methodology to optimize the extraction of acetylcholinesterase inhibitors from Rhodiola sachalinensis . J Korean Soc Appl Biol Chem 57, 807–811 (2014). https://doi.org/10.1007/s13765-014-4293-8

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  • DOI: https://doi.org/10.1007/s13765-014-4293-8

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