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Vitamin B1 supported on alumina as an efficient heterogeneous catalyst for synthesis of tetrahydro-2,6-dioxopyrimidin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives

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Abstract

The efficient synthesis of tetrahydro-2,6-dioxopyrimidin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives via four-component reaction of hydrazine hydrate, phthalic anhydride, aromatic aldehydes and barbituric acid using vitamin B1 supported on alumina (VB1-Al2O3) as a heterogeneous catalyst under thermal solvent-free conditions in excellent yields is described.

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Acknowledgments

We are thankful to the University of Sistan and Baluchestan Research Council for the partial support of this research.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Sistan and Baluchestan, PO Box 98135-674, Zahedan, Iran

    Asiyeh Biabangard & Hamid Reza Shaterian

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  1. Asiyeh Biabangard
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  2. Hamid Reza Shaterian
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Correspondence to Hamid Reza Shaterian.

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Biabangard, A., Shaterian, H.R. Vitamin B1 supported on alumina as an efficient heterogeneous catalyst for synthesis of tetrahydro-2,6-dioxopyrimidin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives. J IRAN CHEM SOC 12, 1529–1534 (2015). https://doi.org/10.1007/s13738-015-0623-y

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  • DOI: https://doi.org/10.1007/s13738-015-0623-y

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