Abstract
We report herein the development of a highly sensitive colorimetric method for detection of d-Penicillamine using citrate-capped gold nanoparticles (AuNPs). This assay relies upon the distance-dependent of gold nanoparticles surface plasmon resonance band of gold nanoparticles. By replacing the thiol-containing chelator drug, d-Penicillamine, with citrate on the gold nanoparticles surface, a new peak appearing at a longer wavelength intensifies and shifts further to the red from the original peak position due to aggregation of gold nanoparticles which depends on ionic strength, gold nanoparticles and d-Penicillamine concentration. During this process, the plasmon band at 521 nm decreases gradually along with the formation of a new red-shifted band at 630 nm. The calibration curve which is derived from the ratio intensities of absorbance at longer wavelength (630 nm) to original wavelength (521 nm) displays a linear relation in the range of 5.0 × 10−6–3.0 × 10−4 M d-Penicillamine. Lower limit of detection for d-Penicillamine, at the signal-to-noise ratio of 3 (3σ), was 3.8 × 10−6 M. The developed methodology was successfully applied for the determination of d-Penicillamine in human urine and plasma.
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Hormozi-Nezhad, M.R., Azargun, M. & Fahimi-Kashani, N. A colorimetric assay for d-Penicillamine in urine and plasma samples based on the aggregation of gold nanoparticles. J IRAN CHEM SOC 11, 1249–1255 (2014). https://doi.org/10.1007/s13738-013-0393-3
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DOI: https://doi.org/10.1007/s13738-013-0393-3