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“On water” organic synthesis: three-component one-pot synthesis of novel bis(1-(cyclohexylamino)-1-oxoalkyl or aryl) fumarates

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Abstract

An efficient synthesis of novel bis(1-(cyclohexylamino)-1-oxoalkyl or aryl) fumarates (4a–k), considering as organic building blocks for natural products and drugs, via the reaction of fumaric acid, various aldehydes and cyclohexyl isocyanide in water using one-pot three-component approach under mild condition and without catalyst is described. This rapid method produced the products in short reaction times (10–15 min) and excellent yields (85–95 %) at room temperature. The structures of the products were deduced from their elemental analyses and spectroscopic data.

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Acknowledgments

We thank the Research Council of University of Guilan for partial support of this study.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Sciences, University of Guilan, P.O. Box 41335-1914, Rasht, Iran

    M. Mamaghani, F. Shirini, N. O. Mahmoodi & A. Azimi-Roshan

  2. Department of Chemistry, University of Payamnoor of Tehran, Tehran, Iran

    A. Monfared

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  1. M. Mamaghani
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  2. F. Shirini
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  3. N. O. Mahmoodi
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  4. A. Azimi-Roshan
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  5. A. Monfared
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Correspondence to M. Mamaghani.

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Mamaghani, M., Shirini, F., Mahmoodi, N.O. et al. “On water” organic synthesis: three-component one-pot synthesis of novel bis(1-(cyclohexylamino)-1-oxoalkyl or aryl) fumarates. J IRAN CHEM SOC 11, 659–664 (2014). https://doi.org/10.1007/s13738-013-0337-y

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  • DOI: https://doi.org/10.1007/s13738-013-0337-y

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