Abstract
A metronidazole-loaded hydrogel was synthesized by free radical polymerization using dimethylaminoethyl methacrylate (DMAEMA) monomer and triethyleneglycol dimethacrylate (TEGDA) and methylene bisacrylamide (MBA) as cross-linkers. The DMAEMA hydrogels were cross-linked with 5 and 10% MBA or with 0.1, 0.5, 1 and 4% TEGDA as cross-linking agents. Ammonium persulfate and tetramethyl ethylene diamine were used as initiator and catalyst, respectively. The prepared hydrogels were characterized, and the effect of cross-linking agent content on the swelling behavior and in vitro drug release of hydrogels was investigated. The results of X-ray diffractometry, differential scanning calorimetry and Fourier transform infrared spectroscopy studies indicated that the prepared hydrogels possessed an amorphous morphology and there was not any interaction between the hydrogel polymers and metronidazole as drug, which resulted in the dependence of drug release on the physicochemical characteristics of hydrogel such as swelling, polymer erosion, and surface morphology. According to the results, the hydrogel containing 0.5% TEGDA which was prepared by freeze-drying method exhibited a porous structure with a high swelling ratio and displayed a sustained and complete drug release. It could be concluded that the hydrogel developed by this facile method is a good candidate with a potential for use in gastroretentive drug delivery systems.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Boyer C, Boutevin G, Robin JJ, Boutevin B (2004) Study of the telomerization of dimethylaminoethyl methacrylate (DMAEMA) with mercaptoethanol: application to the synthesis of a new macromonomer. Polymer 45:7863–7876
Freichel OL, Lippold BC (2004) Artificially induced polymer particle erosion of oral hydrocolloid systems by the addition of insoluble cellulose fibres to fibre-free methylhydroxy ethylcellulose (MHEC). Eur J Pharm Biopharm 57:527–532
Ghorbaniazar P, Sepehrianazar A, Eskandani M, Nabi-Meibodi M, Kouhsoltani M, Hamishehkar H (2015) Preparation of poly acrylic acid-poly acrylamide composite nanogels by radiation technique. Adv Pharm Bull 5:269–275
Hamishehkar H, Nokhodchi A, Ghanbarzadeh S, Kouhsoltani M (2015) Triamcinolone acetonide or a mucoadhesive paste for treatment of aphthous stomatitis. Adv Pharm Bull 5:277–281
Hu X, Tang Y, Wang Q, Li Y, Yang J, Du Y, Kennedy JF (2011) Rheological behaviour of chitin in NaOH/urea aqueous solution. Carbohydr Polym 83:1128–1133
Ispas-Szabo P, Ravenelle F, Hassan I, Preda M, Mateescu MA (1999) Structure–properties relationship in cross-linked high-amylose starch for use in controlled drug release. Carbohydr Res 323:163–175
Korotcenkov G (2015) Porous silicon: from formation to application: formation and properties. CRC Press, Boca Raton
Lam YL, Muniyandy S, Kamaruddin H, Mansor A, Janarthanan P (2015) Radiation cross-linked carboxymethyl sago pulp hydrogels loaded with ciprofloxacin: influence of irradiation on gel fraction, entrapped drug and in vitro release. Radiat Phys Chem 106:213–222
Lemieux M, Gosselin P, Mateescu MA (2015) Carboxymethyl starch mucoadhesive microspheres as gastroretentive dosage form. Int J Pharm 496:497–508
Lin CC, Metters AT (2006) Hydrogels in controlled release formulations: network design and mathematical modeling. Adv Drug Deliver Rev 58:1379–1408
Lopes D, Nunes C, Martins MCL, Sarmento B, Reis S (2014) Eradication of Helicobacter pylori: past, present and future. J Control Release 189:169–186
Peng H, Poovaiah N, Forrester M, Cochran E, Wang Q (2014) Ex vivo culture of primary intestinal stem cells in collagen gels and foams. ACS Biomater Sci Eng 1:37–42
Pushpamalar V, Langford SJ, Ahmad M, Hashim K, Lim YY (2013) Preparation of carboxymethyl sago pulp hydrogel from sago waste by electron beam irradiation and swelling behavior in water and various pH media. J Appl Polym Sci 128:451–459
Ravichandran P, Shantha KL, Rao KP (1997) Preparation, swelling characteristics and evaluation of hydrogels for stomach specific drug delivery. Int J Pharm 154:89–94
Shi Z, Gao X, Ullah MW, Li S, Wang Q, Yang G (2016) Electroconductive natural polymer-based hydrogels. Biomaterials 111:40–54
Song F, Li X, Wang Q, Liao L, Zhang C (2015) Nanocomposite hydrogels and their applications in drug delivery and tissue engineering. J Biomed Nanotech 11:40–52
Sosnik A, das Neves J, Sarmento B (2014) Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review. Prog Polym Sci 39:2030–2075
Thenapakiam S, Kumar DG, Pushpamalar J, Saravanan M (2013) Aluminium and radiation cross-linked carboxymethyl sago pulp beads for colon targeted delivery. Carbohydr Polym 94:356–363
Vakili MR, Rahneshin N (2013) Synthesis and characterization of novel stimuli-responsive hydrogels based on starch and L-aspartic acid. Carbohydr Polym 98:1624–1630
Wang Q, Cheng H, Peng H, Zhou H, Li PY, Langer R (2015) Non-genetic engineering of cells for drug delivery and cell-based therapy. Adv Drug Deliv Rev 91:125–140
Wang Q, Wang J, Lu Q, Detamore MS, Berkland C (2010) Injectable PLGA based colloidal gels for zero-order dexamethasone release in cranial defects. Biomaterials 31:4980–4986
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors report no conflicts of interest.
Rights and permissions
About this article
Cite this article
Farshforoush, P., Ghanbarzadeh, S., Goganian, A.M. et al. Novel metronidazole-loaded hydrogel as a gastroretentive drug delivery system. Iran Polym J 26, 895–901 (2017). https://doi.org/10.1007/s13726-017-0575-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13726-017-0575-4