Abstract
We present the case of a synchronous bilateral low-grade upper-tract urothelial carcinoma patient who underwent left nephroureterectomy and right total ureterectomy with ileal ureteric replacement resulting in a favorable prognosis. A 66-year-old male presented with bilateral hydronephrosis. Computed tomography revealed left pelvic and right upper–middle ureteral tumors with no lymph node swelling or distant metastasis. The patient underwent a left nephroureterectomy with a bladder cuff, and histopathology revealed a low-grade urothelial carcinoma. Considering the contralateral low-grade nature as revealed in histopathology and the right retrograde ureterography being noninvasive, he underwent a right total ureterectomy with ileal ureteric replacement. Histopathology of the right ureter revealed a low-grade urothelial carcinoma. The patient successfully avoided an anephric status without renal function deterioration for 4 years with a transurethral resection for a recurrent small papillary bladder tumor on 18 months after the total ureterectomy.
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References
Seisen T, Peyronnet B, Dominguez-Escrig JL et al (2016) Oncologic outcomes of kidney-sparing surgery versus radical nephroureterectomy for upper tract urothelial carcinoma: a systematic review by the EAU non-muscle invasive bladder cancer guidelines panel. Eur Urol 70:1052–1068
Soria F, Shariat SF, Lerner SP et al (2017) Epidemiology, diagnosis, preoperative evaluation and prognostic assessment of upper-tract urothelial carcinoma (UTUC). World J Urol 35:379–387
Rouprêt M, Babjuk M, Burger M et al (2020) European Association of Urology guidelines on upper urinary tract urothelial carcinoma. Available via DIALOG. https://uroweb.org/guideline/upper-urinary-tract-urothelial-cell-carcinoma/#7
Bagrodia A, Kuehhas FE, Gayed BA et al (2013) Comparative analysis of oncologic outcomes of partial ureterectomy vs radical nephroureterectomy in upper tract urothelial carcinoma. Urology 81:972–977
Colin P, Ouzzane A, Pignot G et al (2012) French Collaborative National Database on U.U.T.-U.C. Comparison of oncological outcomes after segmental ureterectomy or radical nephroureterectomy in urothelial carcinomas of the upper urinary tract: results from a large French multicentre study. BJU Int 110:1134–1141
Lughezzani G, Jeldres C, Isbarn H et al (2009) Nephroureterectomy and segmental ureterectomy in the treatment of invasive upper tract urothelial carcinoma: a population-based study of 2299 patients. Eur J Cancer 45:3291–3297
Fang D, Seisen T, Yang K et al (2009) A systematic review and meta-analysis of oncological and renal function outcomes obtained after segmental ureterectomy versus radical nephroureterectomy for upper tract urothelial carcinoma. EJSO 42:1625–1635
Yakoubi R, Colin P, Seisen T et al (2014) Radical nephroureterectomy versus endoscopic procedures for the treatment of localised upper tract urothelial carcinoma: a meta-analysis and a systematic review of current evidence from comparative studies. Eur J Surg Oncol 40:1629–1634
Jeldres C, Lughezzani G, Sun M et al (2010) Segmental ureterectomy can safely be performed in patients with transitional cell carcinoma of the ureter. J Urol 183:1324–1329
Holmäng S, Johansson SL (2004) Synchronous bilateral ureteral and renal pelvic carcinomas: incidence, etiology, treatment and outcome. Cancer 15(101):741–747
Kang CH, Yu TJ, Hsieh HH et al (2004) Synchronous bilateral primary transitional cell carcinoma of the upper urinary tracts: ten patients with more than five years of follow-up. Urology 63:380–382
Fang D, Xiong G, Li X et al (2009) Incidence, characteristics, treatment strategies, and oncologic outcomes of synchronous bilateral upper tract urothelial carcinoma in the Chinese population. Urol Oncol 33:66.e1–66.e11
Mazeman E (1976) Tumours of the upper urinary tract calyces, renal pelvis and ureter. Eur Urol 2:120–126
Pedrosa JA, Masterson TA, Rice KR et al (2015) Oncologic outcomes and prognostic impact of urothelial recurrences in patients undergoing segmental and total ureterectomy for upper tract urothelial carcinoma. Can Urol Assoc J 9:E187–E192
Ou YC, Hu CY, Cheng HL et al (2018) Long-term outcomes of total ureterectomy with ileal-ureteral substitution treatment for ureteral cancer: a single-center experience. BMC Urol 18:73
Banerji JS, George AJ (2014) Total ureterectomy and ileal ureteric replacement for TCC ureter in a solitary kidney. Can Urol Assoc J 8:E938–E940
Pohar KS, Sheinfeld J (2001) When is partial ureterectomy acceptable for transitional-cell carcinoma of the ureter? J Endourol 15:405–408
Murphy DM, Zincke H, Furlow WL (1980) Primary grade 1 transitional cell carcinoma of the renal pelvis and ureter. J Urol 123:629–631
Giannarini G, Schumacher MC, Thalmann GN et al (2007) Elective management of transitional cell carcinoma of the distal ureter: can kidney-sparing surgery be advised? BJU Int 100:264–268
Campi R, Cotte J, Sessa F et al (2019) Robotic radical nephroureterectomy and segmental ureterectomy for upper tract urothelial carcinoma: a multi-institutional experience. World J Urol 37:2303–2311
Kato T, Nakayama R, Haba T et al (2018) Oncological and renal outcomes of segmental ureterectomy vs. radical nephroureterectomy for upper tract urothelial carcinoma. Oncol Lett 16:6861–6867
Cheng YT, Flechner SM, Chiang PH (2014) The role of laparoscopy-assisted renal autotransplantation in the treatment of primary ureteral tumor. Ann Surg Oncol 21:3691–3697
Armatys SA, Mellon MJ, Beck SD et al (2009) Use of ileum as ureteral replacement in urological reconstruction. J Urol 181:177–181
Chung BI, Hamawy KJ, Zinman LN et al (2006) The use of bowel for ureteral replacement for complex ureteral reconstruction: long-term results. J Urol 175:179–183
Verduyckt FJ, Heesakkers JP, Debruyne FM (2002) Long-term results of ileum interposition for ureteral obstruction. Eur Urol 42:181–187
Sim A, Todenhöfer T, Mischinger J et al (2014) Intracorporeal ileal ureter replacement using laparoscopy and robotics. Cent Eur J Urol 67:420–423
Brandao LF, Autorino R, Zargar H et al (2014) Robotic ileal ureter: a completely intracorporeal technique. Urology 83:951–954
Chen H, Liu L, Pambuccian SE et al (2016) Urine cytology in monitoring recurrence in urothelial carcinoma after radical cystectomy and urinary diversion. Cancer Cytopathol 124:273–278
Flaig TW, Spiess PE, Agarwal N et al. (2020) National Comprehensive Cancer Network clinical practice guidelines in oncology-bladder cancer version3.2020-January 17. Available via DIALOG. https://www.nccn.org/professionals/physician_gls/pdf/bladder.pdf
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Matsuda, Y., Inoue, T., Maeno, A. et al. A patient with synchronous bilateral low-grade upper tract urothelial carcinoma who underwent nephroureterectomy and total ureterectomy with ileal ureteric replacement. Int Canc Conf J 9, 82–87 (2020). https://doi.org/10.1007/s13691-020-00402-w
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DOI: https://doi.org/10.1007/s13691-020-00402-w