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Allergic Contact Dermatitis in Patients with Atopic Dermatitis

  • Contact Dermatitis (B Adler and V Deleo, Section Editors)
  • Published:
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Abstract

Purpose of Review

It is still debated whether the risk of allergic contact dermatitis (ACD) is altered in patients with atopic dermatitis (AD). In this article, the recent literature on the risk of ACD in AD patients is reviewed and put into a clinical context.

Recent Findings

ACD is common in AD patients, but a literature review showed conflicting results on the exact risk compared to non-AD individuals. The development of ACD in AD patients is affected by the dysfunctional skin barrier in particular due to filaggrin deficiency, the Th2 inflammatory immune dysregulation, and microbial dysbiosis. While the increased exposure to topical allergens in AD patients increases the risk of ACD in AD, the Th2-skewed immune response observed in AD reduces the risk of ACD in a severity-dependent manner.

Summary

ACD should be considered in AD patients with eczema worsening, or atypical morphology and generalization despite relevant treatment. Special attention should be paid to the increased risk of ACD to allergens found in topical products.

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Authors and Affiliations

  1. Department of Dermatology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Bispebjerg Bakke 23, 2400, Copenhagen, NV, Denmark

    Yasemin Topal Yüksel, Line Brok Nørreslet & Jacob P. Thyssen

  2. National Allergy Research Centre, Gentofte Hospital, Gentofte Hospitalsvej 1, 2900, Hellerup, Denmark

    Jacob P. Thyssen

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  1. Yasemin Topal Yüksel
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  2. Line Brok Nørreslet
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  3. Jacob P. Thyssen
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Correspondence to Yasemin Topal Yüksel.

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This article is part of the Topical Collection on Contact Dermatitis

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Yüksel, Y.T., Nørreslet, L.B. & Thyssen, J.P. Allergic Contact Dermatitis in Patients with Atopic Dermatitis. Curr Derm Rep 10, 67–76 (2021). https://doi.org/10.1007/s13671-021-00335-4

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  • DOI: https://doi.org/10.1007/s13671-021-00335-4

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