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The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer

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Abstract

Background

Genetic variations in cancer patients may serve as important prognostic indicators of clinical outcome. The GNAS1 T393C single nucleotide polymorphism (SNP) diversely correlates with the clinical outcome in cancer. The aim of this study was to evaluate the potential prognostic value of T393C-SNP in complete resected only surgically treated esophageal cancer (EC).

Methods

Genomic DNA was extracted from peripheral blood leucocytes of 190 patients who underwent only complete surgical resection for EC. T393C-SNP was correlated with clinic-pathological parameters, tumor cell dissemination in bone marrow (DTC) and clinical outcome.

Results

T-allele carriers had more advanced disease due to presence of lymph node metastasis (P < 0.0001) and DTC (P = 0.01) and higher recurrence rate (P = 0.01) compared to CC genotype. The disease-free (P < 0.001) and overall survival (P < 0.001) was better in CC compared to TT and TC patients. In the multivariate Cox regression disease-stage adjusted analysis the T393C-SNP was identified as a strong independent prognostic factor for recurrence (hazard ratio 1.8, P = 0.01) and survival (hazard ratio 2.5, P < 0.001) in EC patients.

Conclusion

Determination of T393C-SNP preoperatively will allow allocation of EC patients into different risk profiles which may help to stratify patients eligible for neoadjuvant and or adjuvant therapy.

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Authors and Affiliations

  1. Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martini Strasse 52, 20246, Hamburg, Germany

    Yogesh Kumar Vashist, Asad Kutup, Safije Musici, Emre F. Yekebas, Sormeh Mina, Guentac Uzunoglu, Oliver Zehler, Alexandra Koenig, Guelle Cataldegirmen, Maximillian Bockhorn, Viacheslav Kalinin & Jakob R. Izbicki

  2. Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, Martini Strasse 52, 20246, Hamburg, Germany

    Katharina Effenberger & Klaus Pantel

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Correspondence to Yogesh Kumar Vashist.

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Yogesh K. Vashist and Asad Kutup have contributed equally to this work.

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Vashist, Y.K., Kutup, A., Musici, S. et al. The GNAS1 T393C single nucleotide polymorphism predicts the natural postoperative course of complete resected esophageal cancer. Cell Oncol. 34, 281–288 (2011). https://doi.org/10.1007/s13402-011-0016-x

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