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Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women

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Abstract

Objective

We suggested association of family history of type 2 diabetes (FHD) with microvascular dysfunction, which may cause blood pressure (BP) elevations. We test whether FHD may be associated with higher BP.

Research design and methods

Resting BP, heart rates (in beats per minute: bpm), body composition and fasting concentrations of glucose, insulin, leptin and adiponectin were measured in 332 Japanese women aged 18–24 years. They were grouped according to BP category defined by the 2017 American College of Cardiology/American Heart Association Blood Pressure Guideline.

Results

BMI averaged < 22 kg/m2 and did not differ cross-sectionally between 73 with (FHD+) and 259 without FHD (FHD−). FHD+ had higher mean (81 ± 9 vs. 77 ± 7 mmHg, p < 0.001), systolic (111 ± 13 vs. 106 ± 10 mmHg, p = 0.003) and diastolic BP (65 ± 8 vs. 60 ± 7 mmHg, p < 0.001). Prevalence of elevated BP (11.0 vs. 6.2%), hypertension stage 1 (4.1 vs. 0.8%) and stage 2 (2.7 vs. 0.4%) was higher as well (p = 0.01). Endurance training in FHD+ abolished the differences in BP readings and BP prevalence. However, the mean resting heart rate in FHD+ athletes (61.2 bpm) was close to those in FHD+ (64.7 bpm) and FHD− nonathletes (64.6 bpm) and was higher than in FHD− athletes (56.5 bpm). Fat mass and distribution evaluated by dual-energy X-ray absorptiometry, markers of insulin resistance, and serum adipokines studied did not differ between the two groups.

Conclusions

FHD was associated with higher BP and higher prevalence of elevated BP and hypertension, suggesting contribution of microvascular dysfunction in BP elevations in normal weight young Japanese women. FHD may be associated with reduced heart rate response to endurance training as well.

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Acknowledgements

We thank all participants for their dedicated and conscientious collaboration.

Author information

Authors and Affiliations

  1. Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan

    Mari Honda, Bin Wu, Tsutomu Kazumi & Keisuke Fukuo

  2. Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women’s University, Kobe, Hyogo, Japan

    Mari Honda

  3. Research Institute for Nutrition Sciences, Mukogawa Women’s University, 6-46, Ikebiraki-cho, Nishinomiya, Hyogo, 663-8558, Japan

    Ayaka Tsuboi, Satomi Minato-Inokawa, Kaori Kitaoka, Mika Takeuchi, Megumu Yano, Miki Kurata, Tsutomu Kazumi & Keisuke Fukuo

  4. Department of Nutrition, Osaka City Juso Hospital, Osaka, Japan

    Ayaka Tsuboi

  5. Laboratory of Community Health and Nutrition, Department of Bioscience, Graduate School of Agriculture, Ehime University, Matsuyama, Ehime, Japan

    Satomi Minato-Inokawa

  6. Department of Food Sciences and Nutrition, School of Food Sciences and Nutrition, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan

    Miki Kurata & Keisuke Fukuo

  7. Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China

    Bin Wu

  8. Department of Medicine, Kohnan Kakogawa Hospital, Kakogawa, Hyogo, Japan

    Tsutomu Kazumi

Authors
  1. Mari Honda
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  2. Ayaka Tsuboi
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  3. Satomi Minato-Inokawa
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  4. Kaori Kitaoka
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  8. Bin Wu
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  9. Tsutomu Kazumi
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Correspondence to Tsutomu Kazumi.

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Honda, M., Tsuboi, A., Minato-Inokawa, S. et al. Association of family history of type 2 diabetes with blood pressure and resting heart rate in young normal weight Japanese women. Diabetol Int 13, 220–225 (2022). https://doi.org/10.1007/s13340-021-00525-2

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  • DOI: https://doi.org/10.1007/s13340-021-00525-2

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