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Association of Anti N-methyl-D-aspartate (NMDA) Receptor Encephalitis with Chediak-Higashi Syndrome

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Abstract

Background

Neurological manifestations of Chediak-Higashi syndrome mainly include peripheral neuropathy, ataxia, tremors, cranial nerve palsies, intellectual decline and seizures.

Case Characteristics

A 2 years 10 month old girl with silvery hair syndrome presented with sub-acute onset behavioral issues, ataxia and multiple type abnormal movements. Cerebrospinal fluid examination was positive for Anti NMDA receptor antibodies. Hair shaft examination and peripheral blood film findings were suggestive of Chediak Higashi syndrome.

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Anti NMDA receptor encephalitis may be associated with Chediak Higashi Syndrome.

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Funding

Funding: None; Competing interest: None stated.

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Authors and Affiliations

  1. Department of Pediatric Neurology, Indira Gandhi Institute of Child Health, Bangaluru, Karnataka, India

    Naveen Bhardwaj & Vykuntaraju K. Gowda

  2. Department of Dermatology, Indira Gandhi Institute of Child Health, Bangaluru, Karnataka, India

    Sahana M. Srinivas

  3. Department of Paediatrics, Indira Gandhi Institute of Child Health, Bangaluru, Karnataka, India

    Nijaguna Nanjundappa

  4. Bangalore Child Neurology and Rehabilitation Centre, Vijaynagar, Bangaluru, 560 040, India

    Vykuntaraju K. Gowda

Authors
  1. Naveen Bhardwaj
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  2. Vykuntaraju K. Gowda
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  3. Sahana M. Srinivas
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  4. Nijaguna Nanjundappa
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Corresponding author

Correspondence to Vykuntaraju K. Gowda.

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Bhardwaj, N., Gowda, V.K., Srinivas, S.M. et al. Association of Anti N-methyl-D-aspartate (NMDA) Receptor Encephalitis with Chediak-Higashi Syndrome. Indian Pediatr 56, 501–503 (2019). https://doi.org/10.1007/s13312-019-1577-4

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  • DOI: https://doi.org/10.1007/s13312-019-1577-4

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