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Disseminated cryptococcosis

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Abstract

Background

Fungal infections, especially in immunocompetent children are uncommon causes of fever of unknown origin.

Case characteristics

A 5-year-old boy with prolonged fever and no evidence of immunosuppression.

Observation

Ultrasound-guided retroperitoneal lymph node biopsy showed granulomas and intracytoplamic fungal yeasts; staining charactristics were suggestive of cryptococci. Clinical and radiological improvement was seen after treatment with amphoterecin-B.

Outcome

Disseminated fungal infection should be suspected as a cause of pyrexia of unknown origin after ruling out the commoner causes. Biopsy from enlarged lymph node or organomegaly may yield the diagnosis when non-invasive tests fail.

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References

  1. Kejariwal D, Sarkar N, Chakraborti SK, Agarwal V, Roy S. Pyrexia of unknown origin: a prospective study of 100 cases. J Postgrad Med. 2001;47:104–107.

    PubMed  CAS  Google Scholar 

  2. Chen SC, Playford EG, Sorrell TC. Antifungal therapy in invasive fungal infections. Curr Opin Pharmacol. 2010;10:1–9.

    Article  CAS  Google Scholar 

  3. Paranada KS, Victorio-Navarra ST, Dy EE. Disseminated cryptococcosis in two Filipino patients. Phil J Microbiol Infect Dis. 1999;28:109–116.

    Google Scholar 

  4. Agarwal V, Sachdev A, Agarwal G, Mohan H, Anjali. Disseminated cryptococcosis mimicking lymphoreticular malignancy in a HIV negative patient. JK Science. 2004;6:93–95.

    Google Scholar 

  5. Lee HS, Park HB, Kim KW, Sohn MH, Kim KE, Kim MJ, et al. A case of mediastinal and pulmonary cryptococcosis in a 3-year-old immunocompetent girl. Pediatr Allergy Respir Dis (Korea). 2011;21:350–355.

    Article  Google Scholar 

  6. Saag MS, Graybill RJ, Larsen RA, Pappas PG, Perfect JR, Powderly WG, et al. Practice guidelines for the management of cryptococcal disease. Clin Infect Dis. 2000;30:710–718.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India

    Meenakshi Bothra, Prakash Selvaperumal & Madhulika Kabra

  2. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Prashant Joshi

Authors
  1. Meenakshi Bothra
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  2. Prakash Selvaperumal
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  3. Madhulika Kabra
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  4. Prashant Joshi
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Corresponding author

Correspondence to Madhulika Kabra.

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Bothra, M., Selvaperumal, P., Kabra, M. et al. Disseminated cryptococcosis. Indian Pediatr 51, 225–226 (2014). https://doi.org/10.1007/s13312-014-0356-5

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  • DOI: https://doi.org/10.1007/s13312-014-0356-5

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