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Consensus guidelines on evaluation and management of suspected acute viral encephalitis in children in India

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Abstract

Justification

Viral encephalitis is an important cause of mortality and morbidity in children. The etiological agents are varied, and physicians treating such children often feel limited by the lack of uniform guidelines on evaluation and management of these critically ill children in resource-constrained settings.

Process

An ‘Expert Group Meeting on Viral Encephalitis in Children’ was held on 19th January, 2012 in Gurgaon, Haryana (under the aegis of PEDICON 2012, the National Conference of Indian Academy of Pediatrics). The invited experts included pediatricians and microbiologists with expertise in the relevant field. Various issues related to the subject were discussed and it was decided to bring out recommendations on the topic. The final recommendations were produced after circulating the draft document, and incorporating/discussing all changes, by e-mail.

Objectives

To aid the pediatrician in the evaluation and management of children with suspected viral encephalitis and to assist the public health authorities in acute encephalitis surveillance. These guidelines do not cover viral encephalitis in the neonatal period and in immunocompromised children, Rabies encephalitis, and chronic viral encephalitis such as Subacute sclerosing panencephalitis (SSPE).

Recommendations

Recommendation for evaluation and management of suspected viral encephalitis in children are presented. In any acute encephalitis outbreak, pediatricians should be aware of the common viral causes of encephalitis in their area, what information and samples they should collect, and the contact details of the District Surveillance Unit. Pending specific diagnosis and therapy (which may or may not be possible), prompt empirical therapy and meticulous supportive care are important to prevent ongoing brain damage, and improve outcome.

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References

  1. Kneen R, Michael BD, Menson E, Mehta B, Easton A, Hemingway C, et al. Management of suspected viral encephalitis in children — Association of British Neurologists and British Pediatric Allergy Immunology and Infection Group National Guidelines. J Infect. 2012;64:449–477.

    Article  PubMed  CAS  Google Scholar 

  2. World Health Oraganisation. Acute Encephalitis Syndrome. Japanese encephalitis surveillance standards. January 2006. From WHO-recommended standards for surveillance of selected vaccine-preventable diseases. WHO/V&B/03.01. Available from: http://www.who.int/vaccines-documents/DocsPDF06/843.pdf. Accessed on 8 August, 2012.

  3. Hollidge BS, Gonzalez-Scarano F, Soldan SS. Arboviral encephalitides: transmission, emergence, and pathogenesis. J Neuroimmune Pharmacol.2010; 5:428–442.

    Article  PubMed  Google Scholar 

  4. Sapkal GN, Bondre VP, Fulmali PV, Patil P, Gopalkrishna V, Dadhania V, et al. Enteroviruses in patients with acute encephalitis, Uttar Pradesh, India. Emerg Infect Dis.2009; 15:295–298.

    Article  PubMed  CAS  Google Scholar 

  5. Karmarkar SA, Aneja S, Khare S, Saini A, Seth A, Chauhan BK. A study of acute febrile encephalopathy with special reference to viral etiology. Indian J Pediatr. 2008; 75:801–805.

    Article  PubMed  CAS  Google Scholar 

  6. Rao BL, Basu A, Wairagkar NS, Gore MM, Arankalle VA, Thakare JP, et al. A large outbreak of acute encephalitis with high fatality rate in children in Andhra Pradesh, India, in 2003, associated with Chandipura virus. Lancet.2004; 364:869–874.

    Article  PubMed  CAS  Google Scholar 

  7. Chadha MS, Arankalle VA, Jadi RS, Joshi MV, Thakare JP, Mahadev PV, et al. An outbreak of Chandipura virus encephalitis in the eastern districts of Gujarat state, India. Am J Trop Med Hyg.2005; 73:566–570.

    PubMed  Google Scholar 

  8. Harit AK, Ichhpujani RL, Gupta S, Gill KS, Lal S, Ganguly NK, et al. Nipah/Hendra virus outbreak in Siliguri, West Bengal, India in 2001. Indian J Med Res. 2006; 123:553–560.

    PubMed  CAS  Google Scholar 

  9. Kalantri SP, Joshi R, Riley LW. Chikungunya epidemic: an Indian perspective. Natl Med J India. 2006; 19:315–322.

    PubMed  CAS  Google Scholar 

  10. Kumar R, Tripathi S, Tambe JJ, Arora V, Srivastava A, Nag VL. Dengue encephalopathy in children in Northern India: clinical features and comparison with non dengue. J Neurol Sci. 2008; 269:41–48.

    Article  PubMed  Google Scholar 

  11. Steiner I. Herpes simplex virus encephalitis: new infection or reactivation? Curr Opin Neurol. 2011; 24:268–274.

    Article  PubMed  Google Scholar 

  12. Granerod J, Ambrose HE, Davies NW, Clewley JP, Walsh AL, Morgan D, et al. Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study. Lancet Infect Dis. 2010; 10:835–844.

    Article  PubMed  Google Scholar 

  13. Wairagkar NS, Shaikh NJ, Ratho RK, Ghosh D, Mahajan RC, Singhi S, et al. Isolation of measles virus from cerebrospinal fluid of children with acute encephalopathy without rash. Indian Pediatr.2001; 38:589–595.

    PubMed  CAS  Google Scholar 

  14. John TJ. Encephalopathy without rash, caused by measles virus? More evidence is needed. Indian Pediatr. 2003; 40:589–593.

    PubMed  Google Scholar 

  15. Kumar S. Inadequate research facilities fail to tackle mystery disease. BMJ. 2003; 326:12.

    Article  PubMed  Google Scholar 

  16. Tyler KL. Emerging viral infections of the central nervous system: part 2. Arch Neurol. 2009; 66:1065–1074.

    Article  PubMed  Google Scholar 

  17. Tyler KL. Emerging viral infections of the central nervous system: part 1. Arch Neurol. 2009; 66:939–948.

    Article  PubMed  Google Scholar 

  18. Benjamin LA, Lewthwaite P, Vasanthapuram R, Zhao G, Sharp C, Simmonds P, et al. Human parvovirus 4 as potential cause of encephalitis in children, India. Emerg Infect Dis. 2011; 17:1484–1487.

    PubMed  Google Scholar 

  19. Khan SA, Dutta P, Khan AM, Chowdhury P, Borah J, Doloi P, et al. West Nile virus infection, Assam, India. Emerg Infect Dis. 2011; 17:947–948.

    Article  PubMed  Google Scholar 

  20. Thakare JP, Rao TL, Padbidri VS. Prevalence of West Nile virus infection in India. Southeast Asian J Trop Med Public Health. 2002; 33:801–805.

    PubMed  CAS  Google Scholar 

  21. Bondre VP, Sapkal GN, Yergolkar PN, Fulmali PV, Sankararaman V, Ayachit VM, et al. Genetic characterization of Bagaza virus (BAGV) isolated in India and evidence of anti-BAGV antibodies in sera collected from encephalitis patients. J Gen Virol. 2009;90:2644–2649.

    Article  PubMed  CAS  Google Scholar 

  22. Kumar A, Shukla D, Kumar R, Idris MZ, Misra UK, Dhole TN. An epidemic of encephalitis associated with human enterovirus B in Uttar Pradesh, India, 2008. J Clin Virol. 2011; 51:142–145.

    Article  PubMed  Google Scholar 

  23. Glaser CA, Honarmand S, Anderson LJ, Schnurr DP, Forghani B, Cossen CK, et al. Beyond viruses: clinical profiles and etiologies associated with encephalitis. Clin Infect Dis. 2006; 43:1565–1577.

    Article  PubMed  CAS  Google Scholar 

  24. Vashishtha VM, Kumar A, John TJ, Nayak NC. Cassia occidentalis poisoning causes fatal coma in children in western Uttar Pradesh. Indian Pediatr.2007; 44:522–525.

    PubMed  Google Scholar 

  25. Sriramachari S. Heat hyperpyrexia: time to act. Indian J Med Res.2004; 119:vii–x.

    PubMed  CAS  Google Scholar 

  26. Ghosh D, Dhadwal D, Aggarwal A, Mitra S, Garg SK, Kumar R, et al. Investigation of an epidemic of Reye’s syndrome in northern region of India. Indian Pediatr.1999;36:1097–1106.

    PubMed  CAS  Google Scholar 

  27. John TJ, Date A, Patoria NK. Acute encephalopathy in children in Nagpur: similarity to Reye’s syndrome. Indian J Pediatr. 1983; 50:129–132.

    Article  PubMed  CAS  Google Scholar 

  28. John TJ. Outbreak of killer brain disease in children: mystery or missed diagnosis? Indian Pediatr. 2003;40:863–869.

    PubMed  Google Scholar 

  29. Japanese Encephalitis Clinical Care Guidelines. PATH, November, 2006. Available from: www.path.org/vaccineresources/filesJE_clinical_care_guidelines_PATH.pdf. Accessed on 3 August, 2012.

  30. Ministry of Health and Family Welfare, Government of India. Facility-based IMNCI (F-IMNCI) Participants Manual. Government of India, New Delhi, 2009. Available from:www.unicef.org/india/FBC_Participants_Manual.pdf. Accessed on 3 August, 2012.

    Google Scholar 

  31. Davis LE, Tyler KL. Molecular diagnosis of CNS viral infections. J Neurol Neurosurg Psychiatry. 2005; 76:10.

    Article  PubMed  CAS  Google Scholar 

  32. Sharma S, Kochar GS, Sankhyan N, Gulati S. Approach to the child with coma. Indian J Pediatr. 2010; 77:1279–1287.

    Article  PubMed  Google Scholar 

  33. Wang GF, Li W, Li K. Acute encephalopathy and encephalitis caused by influenza virus infection. Curr Opin Neurol. 2001; 23:305–311.

    Article  Google Scholar 

  34. John TJ, Maiya PP, Jadhav M, Christopher S, Mukundan P. Mumps virus meningitis and encephalitis without parotitis. Indian J Med Res. 1978; 68:883–886.

    PubMed  CAS  Google Scholar 

  35. Johnstone JA, Ross CA, Dunn M. Meningitis and encephalitis associated with mumps infection. A 10-year survey. Arch Dis Child. 1972; 47:647–651.

    Article  PubMed  CAS  Google Scholar 

  36. Elbers JM, Bitnun A, Richardson SE, Ford-Jones EL, Tellier R, Wald RM, et al. A 12-year prospective study of childhood herpes simplex encephalitis: is there a broader spectrum of disease? Pediatrics. 2007;119:e399–e407.

    Article  PubMed  Google Scholar 

  37. Kirkham FJ, Newton CR, Whitehouse W. Paediatric coma scales. Dev Med Child Neurol. 2008; 50:267–274.

    Article  PubMed  Google Scholar 

  38. Stevens RD, Bhardwaj A. Approach to the comatose patient. Crit Care Med. 2006; 34:31–41.

    Article  PubMed  Google Scholar 

  39. Steer AC, Starr M, Kornberg AJ. Bickerstaff brainstem encephalitis associated with Mycoplasma pneumoniae infection. J Child Neurol. 2006; 21:533–534.

    PubMed  Google Scholar 

  40. Taylor DA. Impairment of consciousness and coma. Philadelphia: Elsevier, 2006.

    Google Scholar 

  41. Brazis PW, Biller J. Coma. Philadelphia: Lippincott Williams and Wilkins, 2001.

    Google Scholar 

  42. Ooi MH, Wong SC, Lewthwaite P, Cardosa MJ, Solomon T. Clinical features, diagnosis, and management of enterovirus 71. Lancet Neurol. 2010; 9:1097–1105.

    Article  PubMed  Google Scholar 

  43. Kumar R, Tripathi P, Singh S, Bannerji G. Clinical features in children hospitalized during the 2005 epidemic of Japanese encephalitis in Uttar Pradesh, India. Clin Infect Dis. 2006; 43:123–131.

    Article  PubMed  Google Scholar 

  44. Schemann JF, Doumbo O, Malvy D, Traore L, Kone A, Sidibe T, et al. Ocular lesions associated with malaria in children in Mali. Am J Trop Med Hyg. 2002; 67:61–63.

    PubMed  Google Scholar 

  45. Kuno G. Serodiagnosis of flaviviral infections and vaccinations in humans. Adv Virus Res. 2003; 61:3–65.

    Article  PubMed  Google Scholar 

  46. Hua R, Chen N, Qin C, Deng Y, Ge J, Wang X, et al. Identification and characterization of a virus-specific continuous B-cell epitope on the PrM/M protein of Japanese encephalitis virus: potential application in the detection of antibodies to distinguish Japanese encephalitis virus infection from West Nile virus and Dengue virus infections. Virology J. 2010; 7:249.

    Article  Google Scholar 

  47. Sankhyan N, Vykunta Raju KN, Sharma S, Gulati S. Management of raised intracranial pressure. Indian J Pediatr. 2010; 77:1409–1416.

    Article  PubMed  Google Scholar 

  48. Suarez JI. Hypertonic saline for cerebral edema and elevated intracranial pressure. Cleve Clin J Med. 2004; 71Suppl 1:S9–S13.

    Article  PubMed  Google Scholar 

  49. Rabinstein AA. Treatment of cerebral edema. Neurologist. 2006; 12:59–73.

    Article  PubMed  Google Scholar 

  50. Kamei S, Sekizawa T, Shiota H, Mizutani T, Itoyama Y, Takasu T, et al. Evaluation of combination therapy using aciclovir and corticosteroid in adult patients with herpes simplex virus encephalitis. J Neurol Neurosurg Psychiatry.2005; 76:1544–1549.

    Article  PubMed  CAS  Google Scholar 

  51. Martinez-Torres F, Menon S, Pritsch M, Victor N, Jenetzky E, Jensen K, et al. Protocol for German trial of acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial (ISRCTN45122933). BMC Neurol. 2008; 8:40.

    Article  PubMed  Google Scholar 

  52. Hoke CH Jr., Vaughn DW, Nisalak A, Intralawan P, Poolsuppasit S, Jongsawas V, et al. Effect of high-dose dexamethasone on the outcome of acute encephalitis due to Japanese encephalitis virus. J Infect Dis. 1992; 165:631–637.

    Article  PubMed  Google Scholar 

  53. Steiner I, Budka H, Chaudhuri A, Koskiniemi M, Sainio K, Salonen O, et al. Viral meningoencephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol. 2010; 17:999–e957.

    Article  PubMed  CAS  Google Scholar 

  54. Rotbart HA, Webster AD. Treatment of potentially life-threatening enterovirus infections with pleconaril. Clin Infect Dis. 2001; 32:228–235.

    Article  PubMed  CAS  Google Scholar 

  55. Wang SM, Lei HY, Huang MC, Su LY, Lin HC, Yu CK, et al. Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis. J Clin Virol. 2006; 37:47–52.

    Article  PubMed  CAS  Google Scholar 

  56. Kumar R, Tripathi P, Baranwal M, Singh S, Tripathi S, Banerjee G. Randomized, controlled trial of oral ribavirin for Japanese encephalitis in children in Uttar Pradesh, India. Clin Infect Dis. 2009;48:400–406.

    Article  PubMed  CAS  Google Scholar 

  57. Dutta K, Kumawat KL, Nazmi A, Mishra MK, Basu A. Minocycline differentially modulates viral infection and persistence in an experimental model of Japanese encephalitis. J Neuroimmune Pharmacol. 2010; 5:553–565.

    Article  PubMed  Google Scholar 

  58. George K. Investigating outbreaks of uncertain aetiologies. Indian J Med Res. 2007;125:505–507.

    PubMed  Google Scholar 

  59. Japanese encephalitis vaccines. Wkly Epidemiol Rec. 2006;81:331–340.

    Google Scholar 

  60. Fischer M, Lindsey N, Staples JE, Hills S. Japanese encephalitis vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2010; 59:1–27.

    Google Scholar 

  61. Halstead SB, Thomas SJ. New Japanese encephalitis vaccines: alternatives to production in mouse brain. Expert Rev Vaccines. 2011;10:355–364.

    Article  PubMed  CAS  Google Scholar 

  62. Indian Academy of Pediatrics. IAP Guidebook on Immunization, IAP, Mumbai, 2009. Available from: http://www.indg.in/health/child-health/IAP%20GUIDE%20BOOK%20ON%20IMMUNIZATION%202009-2011._pdf. Accessed on 8 August, 2012.

  63. Government of India. Operational Guide Japanese Encephalitis Vaccination in India. Immunization Division Department of Family Welfare, Ministry of Health and Family Welfare, Government of India; September 2010. Available from http://health.bih.nic.in/Docs/Guidelines-Japanese-Encephalitis.pdf. Accessed on 11 October, 2012.

  64. Kumar R, Tripathi P, Rizvi A. Effectiveness of one dose of SA 14-14-2 vaccine against Japanese encephalitis. N Engl J Med. 2009; 360:1465–1466.

    Article  PubMed  CAS  Google Scholar 

  65. Indian Council of Medical Research. Minutes of the meeting of the Core Committee on Vaccines. Available from: http://www.icmr.nic.in/minutesMinutes%20Core%20Committee%20on%20Vaccines.pdf. Accessed on March 28, 2012.

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Correspondence to Devendra Mishra.

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Sharma, S., Mishra, D., Aneja, S. et al. Consensus guidelines on evaluation and management of suspected acute viral encephalitis in children in India. Indian Pediatr 49, 897–910 (2012). https://doi.org/10.1007/s13312-012-0216-0

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