Abstract
Biomedical research forms the basis of evidence based practices in the field of health and nutrition. However, it is, increasingly being seen that conflicts of interest and misconduct are undermining research. More and more instances of using research to promote commercial interest are being reported. Fraudulent means, in the quest to publish, are also being used. This article discusses conflict of interest and misconduct in bio-medical research, reviews scientific evidence available on the subject, and proposes some solutions to check the menace.
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Sackett DL, Rosenberg WM, Gray JA, Haynes RB, Richardson WS. Evidence based medicine: what it is and what it isn’t. BMJ. 1996; 312:71–72.
Evidence-Based Medicine Working Group. Evidencebased medicine. A new approach to teaching the practice of medicine. JAMA. 1992; 268:2420–2425.
Thompson DF. Understanding financial conflicts of interest. N Engl J Med. 1993; 329:573–576.
Kassirer JP, Angell M. Financial conflicts of interest in biomedical research. N Engl J Med. 1993; 329:570–571.
International Committee of Medical Journal Editors [ICMJE]. Uniform requirements for manuscripts submitted to biomedical journals. Available at: http://www.icmje.org/coi_disclosure.pdf. Accessed on April 25, 2012.
Campbell EG, Zinner DE. Disclosing industry relationships—toward an improved federal research policy. N Engl J Med. 2010; 363:604–606.
Godlee F, Wager E. Research misconduct in the UK. BMJ. 2012; 344:d8357.
Tavare A. Managing research misconduct: is anyone getting it right? BMJ. 2011; 343:d8212.
Indian Council of Medical Research (2006). Ethical guidelines for Biomedical Research on Human subjects. Available at: http://icmr.nic.in/ethical_guidelines.pdf. Accessed on April 30, 2012.
Lee K, Mills A. Strengthening governance for global health research. BMJ. 2000; 321:775–776.
Perlis RH, Perlis CS, Wu Y, Hwang C, Joseph M, Nierenberg AA. Industry sponsorship and financial conflict of interest in the reporting of clinical trials in psychiatry. Am J Psychiatry. 2005; 162:1957–1960.
Friedman LS, Richter ED. Relationship between conflicts of interest and research results. J Gen Intern Med. 2004; 19:51–56.
Blumenthal D, Gluck M, Louis KS, Stoto MA, Wise D. University-industry research relationships in biotechnology: implications for the university. Science. 1986; 232:1361–1366.
Smith R. Beyond conflict of interest. Transparency is the key. BMJ. 1998; 317:291–292.
Falkner F. Editorial. Int Child Health. 1997; viii:1.
Lucas A. Collaborative research with infant formula companies should not always be censored. BMJ. 1998; 317:333–339.
Rundall P. How much research in infant feeding comes from unethical marketing? BMJ. 1998; 317:333–339.
Blum JA, Freeman K, Dart RC, Cooper RJ. Requirements and definitions in conflict of interest policies of medical journals. JAMA. 2009; 302:2230–2234.
Jaykaran, Yadav P, Chavda N, Kantharia ND. Survey of “instructions to authors” of Indian medical journals for reporting of ethics and authorship criteria. Indian J Med Ethics. 2011; 8:36–38.
Wilkes MS, Kravitz RL. Policies, practices, and attitudes of North American medical journal editors. J Gen Intern Med. 1995; 10:443–450.
Sacristán JA, Bolaños E, Hernández JM, Soto J, Galende I. Publication bias in health economic studies. Pharmacoeconomics. 1997; 11:289–292.
Moynihan R, Bero L, Ross-Degnan D, Henry D, Lee K, Watkins J, et al. Coverage by the news media of the benefits and risks of medications. N Engl J Med. 2000;342:1645–1650.
Lo B. Serving two masters — Conflicts of interest in academic medicine. N Engl J Med. 2010;362:669–671.
Chandra RK. Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects. Nutrition. 2001;17;709–712.
Meguid MM. Retraction of Chandra RK. Effect of vitamin and trace-element supplementation on cognitive function in elderly subjects.(In-Nutrition. 2001;17:709–12); Nutrition 2005;21:286.
Smith R. Investigating the previous studies of a fraudulent author. BMJ. 2005;331:288–291.
Hamblin T. The secret life of Dr Chandra. BMJ. 2006;332:369.
INFACT Canada. Nestlé Scientist’s False Claims Exposed. Available at: http://www.infactcanada.ca/Chandra_Feb72006.htm. Accessed on April 25, 2012.
Cohen D. Rosiglitazone: what went wrong? BMJ. 2010;341:c4848.
Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007;356:2457–2471.
Home PD, Pocock SJ, Beck-Nielsen H, Curtis PS, Gomis R, Hanefeld M, et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes [RECORD]: a multicentre, randomised, open-label trial. Lancet. 2009;373:2125–2135.
The United States Senate Committee on Finance. Grassley, Baucus release committee report on Avandia. Available at: http://finance.senate.gov/newsroom/chairman/release/?id=bc56b552-efc5-4706-968df7032d5cd2e4. Accessed on April 25, 2012.
Editorial. Strengthening the credibility of clinical research. Lancet. 2010;375:1225.
Wang AT, McCoy CP, Murad MH, Montori VM. Association between industry affiliation and position on cardiovascular risk with rosiglitazone: cross sectional systematic review. BMJ. 2010;340:c1344.
Stern S, Lemmens T. Legal remedies for medical ghost writing: imposing fraud liability on guest authors of ghost written articles. PLoS Med. 2010;8:e1001070. Epub 2011 Aug 2.
Ross JS, Hill KP, Egilman DS, Krumholz HM. Guest authorship and ghost writing in publications related to rofecoxib: a case study of industry documents from rofecoxib litigation. JAMA. 2008;299:1800–1812.
Williams MJ, Kevat DA, Loff B. Conflict of interest guidelines for clinical guidelines. Med J Aust. 2011;95:442–445.
Cohen D, Carter P. Conflicts of interest. WHO and the pandemic flu “conspiracies”. BMJ. 2010;340:c2912.
Williams MJ, Kevat DA, Loff B. Conflict of interest guidelines for clinical guidelines. Med J Aust. 2011;195:442–445.
Neuman J, Korenstein D, Ross JS, Keyhani S. Prevalence of financial conflicts of interest among panel members producing clinical practice guidelines in Canada and United States: cross sectional study. BMJ. 2011;343:d5621.
Barnes DE, Bero LA. Why review articles on the health effects of passive smoking reach different conclusions. JAMA. 1998;279:1566–1570.
WHO. International Clinical Trials Registry Platform [ICTRP]. Available at: http://www.who.int/ictrp/child/en/. Accessed on March 21, 2012.
National Institute of Medical Statistics [NIMS]. The Clinical Trials Registry-India [CTRI]. Available at: http://ctri.nic.in/Clinicaltrials/cont1.php. Accessed on March 21, 2012.
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Dadhich, J.P. Tackling conflict of interest and misconduct in biomedical research. Indian Pediatr 49, 527–531 (2012). https://doi.org/10.1007/s13312-012-0114-5
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DOI: https://doi.org/10.1007/s13312-012-0114-5