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Tryptophan for the treatment of excessive daytime sleepiness in Prader-Willi Syndrome

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Abstract

An 8-year old girl with Prader-Willi Syndrome presenting with excessive daytime sleepiness improved following treatment with tryptophan; possibly by consolidation of her fragmented sleep. Improvement was recorded on a follow-up sleep study, one year after initiating treatment with tryptophan. We conclude that tryptophan may be an useful medication for excessive sleepiness in children with Prader-Willi Syndrome.

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Authors and Affiliations

  1. Psychiatric Department of Gachon University Gil Hospital, Incheon, Republic of Korea

    Yu Jin Lee

  2. Youthdale Child and Adolescent Centre, Toronto, Ontario, Canada

    Shai Marcu & Colin M. Shapiro

  3. Pediatric Department of North York General Hospital, Toronto, Ontario, Canada

    Glenn Berall

  4. Youthdale Child and Adolescent Sleep Centre 227 Victoria, St Lower Level 2, Toronto, ON, Canada, M5B1T8

    Colin M. Shapiro

Authors
  1. Yu Jin Lee
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  2. Shai Marcu
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  3. Glenn Berall
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  4. Colin M. Shapiro
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Correspondence to Colin M. Shapiro.

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Lee, Y.J., Marcu, S., Berall, G. et al. Tryptophan for the treatment of excessive daytime sleepiness in Prader-Willi Syndrome. Indian Pediatr 48, 319–328 (2011). https://doi.org/10.1007/s13312-011-0053-6

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  • DOI: https://doi.org/10.1007/s13312-011-0053-6

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