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Intrauterine infusion of platelet-rich plasma for severe Asherman syndrome: a cutting-edge approach

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Abstract

Asherman syndrome (AS) consists of intrauterine adhesions development as a consequence of trauma, radiation, or infection in the endometrium. Clinical symptoms include menstrual alterations, infertility, and pregnancy complications, such as recurrent pregnancy loss or abnormal placentation. In this article, we performed a narrative review of the literature, searching electronic databases (i.e., Medline, Pubmed, and Google Scholar) to summarize the available pieces of evidence about epidemiology, pathophysiology, diagnosis, and treatment of AS. Hysteroscopy is essential for diagnosis and treatment, although adhesions may recur. Different postoperative therapies have been proposed to prevent recurrence and restore impaired endometrial function and promote endometrial regeneration, although these effects are usually temporary. We report a case of AS with adhesion recurrence and endometrial atrophy who was successfully treated with intrauterine autologous platelet–rich plasma (PRP) infusion. This therapy allowed endometrial tissue regeneration, leading to increased vascularity and endometrium thickness, and restoration of endometrial function that led to a successful pregnancy. Though there is limited experience supporting the use of PRP to improve endometrial function, it has been safely used in other fields of medicine; besides, it is easy to obtain, not expensive, and harmless being an autologous source. Future studies are encouraged to further assess this approach to treat AS.

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Authors and Affiliations

  1. Fertia Clinic, Fuengirola, Málaga, Spain

    Elena Puente Gonzalo & Auxiliadora Vega Jiménez

  2. Centro Gutenberg, Málaga, Spain

    Luis Alonso Pacheco

  3. Obstetrics and Gynecology Unit, Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy

    Salvatore Giovanni Vitale

  4. Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy

    Antonio Raffone

  5. Department of Obstetrics and Gynecology, “Filippo Del Ponte” Hospital, University of Insubria, Varese, Italy

    Antonio Simone Laganà

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  1. Elena Puente Gonzalo
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  2. Luis Alonso Pacheco
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  3. Auxiliadora Vega Jiménez
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  4. Salvatore Giovanni Vitale
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  5. Antonio Raffone
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  6. Antonio Simone Laganà
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Correspondence to Salvatore Giovanni Vitale.

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Puente Gonzalo, E., Alonso Pacheco, L., Vega Jiménez, A. et al. Intrauterine infusion of platelet-rich plasma for severe Asherman syndrome: a cutting-edge approach. Updates Surg 73, 2355–2362 (2021). https://doi.org/10.1007/s13304-020-00828-0

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