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Association between XRCC3 Thr241Met polymorphism and nasopharyngeal carcinoma risk: evidence from a large-scale case-control study and a meta-analysis

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Tumor Biology

Abstract

The X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism (rs861539, C > T) has drawn wide attentions as its association with cancer risk and its involvement in DNA repair. Several studies have attempted to link rs861539 to nasopharyngeal cancer (NPC) risk; however, the sample sizes of these studies are small and the results are controversial. To investigate the relationship of rs861539 and NPC susceptibility, we conducted a large-scale case-control study involving 4001 NPC cases and 2967 controls of southern Chinese. Logistic regression analysis revealed significant association for rs861539 and NPC risk under the recessive model (TT vs. CT + CC) with adjustment of age and gender (odds ratio, OR = 2.72; 95 % CI 1.10–6.72; P = 0.03). Further, meta-analysis involving 4457 NPC cases and 4132 controls from four studies showed consistent association of TT carriers and NPC risk (OR = 3.12; 95 % CI 1.58–6.13; P = 0.001). Taken together, our findings based on large-scale sample size suggested rs861539 at XRCC3 to be associated with NPC risk through recessive model.

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Acknowledgments

This work was supported by the National Basic Research Program of China (2011CB504302), the National Natural Science Foundation of China (81222035), and the National Natural Science Foundation of China (81430059). We thanked all the participants in our study and appreciated the contributions of the staffs from the biobank at the Sun Yat-sen University Cancer Center.

Author contributions

Jin-Xin Bei and Yi-Xin Zeng conceived and designed the experiments; Qian Cui performed the experiments; Qian Cui and Xiao-Yu Zuo analyzed the data; Qi-Sheng Feng, Yun-Fei Xia, Wei-Hua Jia, Li-Zhen Chen and Hai-Qiang Mai contributed reagents and materials; Qian Cui, Jin-Xin Bei, Yi-Fan Lian and Cai-Yun He wrote the paper.

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Authors and Affiliations

  1. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China

    Qian Cui, Xiao-Yu Zuo, Yi-Fan Lian, Qi-Sheng Feng, Yun-Fei Xia, Cai-Yun He, Li-Zhen Chen, Wei-Hua Jia, Hai-Qiang Mai, Yi-Xin Zeng & Jin-Xin Bei

  2. Department of Experimental Research, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China

    Qian Cui, Xiao-Yu Zuo, Yi-Fan Lian, Qi-Sheng Feng, Li-Zhen Chen, Wei-Hua Jia, Yi-Xin Zeng & Jin-Xin Bei

  3. Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China

    Yun-Fei Xia

  4. Department of Molecular Diagnosis, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China

    Cai-Yun He

  5. Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China

    Hai-Qiang Mai

  6. Beijing Hospital, Beijing, 100730, China

    Yi-Xin Zeng

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  1. Qian Cui
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  2. Xiao-Yu Zuo
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  10. Yi-Xin Zeng
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Corresponding authors

Correspondence to Yi-Xin Zeng or Jin-Xin Bei.

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All subjects were self-reported residing in Guangdong province in south China, which is NPC prevalent area. Informed consent was obtained and the study was approved by the Ethics Committee of SYSUCC.

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Additional information

Qian Cui and Xiao-Yu Zuo equally contributed to the work.

Yi-Xin Zeng and Jin-Xin Bei jointly supervised the work.

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Cui, Q., Zuo, XY., Lian, YF. et al. Association between XRCC3 Thr241Met polymorphism and nasopharyngeal carcinoma risk: evidence from a large-scale case-control study and a meta-analysis. Tumor Biol. 37, 14825–14830 (2016). https://doi.org/10.1007/s13277-016-5300-y

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