Abstract
Macrophages play crucial roles in promoting tumor development and progression. In the present study, we found that the mannose-sensitive hemagglutination pilus strain of Pseudomonas aeruginosa (PA-MSHA) was efficient in inducing M1 macrophage polarization. PA-MSHA treatment increases expression of M1-related cytokines and promotes activation of murine peritoneal macrophages (MPM). Interestingly, PA-MSHA inhibits cell proliferation and migration and induces the apoptosis of gastric carcinoma cells. These effects of PA-MSHA on M1 polarization were associated with activation of NF-κB expression. Thus, inducing polarization of M1 by PA-MSHA may be one potential strategy for inhibiting gastric carcinoma progression in mice.
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This work was carried out with the support of “Youth start-up Foundation of Changzheng hospital (Project No. 2013CZQN10).”
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The animal experiment was carried out in accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals, with the approval of the Scientific Investigation Board of the Second Military Medical University (Shanghai, China).
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Changming Wang, Zunqi Hu and Zhenxin Zhu contributed equally to this work.
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Wang, C., Hu, Z., Zhu, Z. et al. The MSHA strain of Pseudomonas aeruginosa (PA-MSHA) inhibits gastric carcinoma progression by inducing M1 macrophage polarization. Tumor Biol. 37, 6913–6921 (2016). https://doi.org/10.1007/s13277-015-4451-6
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DOI: https://doi.org/10.1007/s13277-015-4451-6