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Research progress on the multidrug resistance mechanisms of osteosarcoma chemotherapy and reversal

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Tumor Biology

Abstract

Osteosarcoma (OS) is the most common and aggressive primary malignant type of bone cancer in children and adolescents. Chemotherapy is one of the most important treatments for OS. Although cancer therapy has improved over the past few decades, survival outcomes for OS patients remain unsatisfactory. One of the primary reasons for the failure of current treatments is that patients with stage IV cancer often develop resistance to anticancer agents. This article will review multidrug resistance (MDR) mechanisms of OS and strategies for overcoming resistance.

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    1. Department of Orthopedics, Shanghai First People’s Hospital, Nanjing Medical University, 100 Haining Rd, Shanghai, 200072, China

      Suoyuan Li & Zhengdong Cai

    2. Department of Orthopedics, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200072, China

      Wei Sun & Yingqi Hua

    3. Department of Orthopedics, Shanghai 10th People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, China

      Hongsheng Wang & Dongqing Zuo

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    1. Suoyuan Li
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    Correspondence to Yingqi Hua or Zhengdong Cai.

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    Suoyuan Li and Wei Sun contributed equally to this work.

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    Li, S., Sun, W., Wang, H. et al. Research progress on the multidrug resistance mechanisms of osteosarcoma chemotherapy and reversal. Tumor Biol. 36, 1329–1338 (2015). https://doi.org/10.1007/s13277-015-3181-0

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