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RETRACTED ARTICLE: Nrdp1 inhibits metastasis of colorectal cancer cells by EGFR signaling-dependent MMP7 modulation

  • Research Article
  • Published:
Tumor Biology

This article was retracted on 20 April 2017

Abstract

The molecular mechanism underlying cancer invasiveness and metastasis of colorectal cancer (CRC) remains elusive. Here we reported a strong correlation of the levels of neuregulin receptor degradation protein-1 (Nrdp1) and matrix metalloproteinase-7 (MMP7) in CRC from the patients. We then used a human CRC line, Caco-2, to study the underlying molecular basis. We found that Nrdp1 inhibited the phosphorylation of ErB3, a key player in epidermal growth factor receptor (EGFR) signaling in Caco-2 cells, which is required for activation of MMP7 to promote cell invasion. Our findings thus reveal Nrdp1, EGFR signaling, and MMP7 as promising therapeutic targets for preventing the metastasis of CRC.

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Authors and Affiliations

  1. Department of General Surgery, Jinan Central Hospital, Shandong University, Jinan, 250013, China

    Yongsheng Jiang, Shaochuan Sun, Guoqin Liu & Bing Yan

  2. Department of General Surgery, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan, 250012, China

    Jun Niu

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  1. Yongsheng Jiang
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  2. Shaochuan Sun
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  3. Guoqin Liu
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  4. Bing Yan
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  5. Jun Niu
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Corresponding author

Correspondence to Jun Niu.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article is available at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Jiang, Y., Sun, S., Liu, G. et al. RETRACTED ARTICLE: Nrdp1 inhibits metastasis of colorectal cancer cells by EGFR signaling-dependent MMP7 modulation. Tumor Biol. 36, 1129–1133 (2015). https://doi.org/10.1007/s13277-014-2726-y

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  • DOI: https://doi.org/10.1007/s13277-014-2726-y

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