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Increased PTOV1 expression is related to poor prognosis in epithelial ovarian cancer

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Tumor Biology

Abstract

Altered expression of prostate tumor overexpressed-1 (PTOV1) is observed in various types of human cancers. However, the role of PTOV1 in epithelial ovarian cancer (EOC) remains unclear. PTOV1 messenger (m)RNA expression in EOC patients was evaluated by quantitative real-time PCR (qRT-PCR). PTOV1 protein expression was also analyzed in archived paraffin-embedded EOC tissues using immunohistochemistry (IHC), and its association with overall survival of patients was analyzed by statistical analysis. Results from qRT-PCR analysis show that the expression level of PTOV1 mRNA was significantly higher in tumor tissues of EOC, compared to that in adjacent noncancerous tissues (P < 0.001). IHC staining showed that high expression of PTOV1 was detected in 57.2 % (87/152) of EOC cases. High expression of PTOV1 was significantly associated with pathological grade (P = 0.029) and clinical stage (P = 0.001). Moreover, the results of Kaplan-Meier analysis indicated that a high expression level of PTOV1 resulted in a significantly poor prognosis of EOC patients. Multivariate analysis showed that high expression of PTOV1 was an independent prognostic factor for overall survival (P < 0.001). In conclusion, PTOV1 protein abnormal expression might contribute to the malignant progression of EOC. High expression of PTOV1 predicts poor prognosis in patients with EOC.

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Acknowledgments

This research was supported by grant from 973 Foundation (2013CB531606).

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Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China

    Fei Guo

  2. Department of Oncology, No. 3 People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 280, Mohe Road, Baoshan District, Shanghai, 201900, China

    Liu Feng & Mei-Ling Wang

  3. Department of Oncological Surgery, Jiangxi Tumor Hospital, No. 519, Beijing East Road, Nanchang, 330029, China

    Ji-Long Hu

  4. TopGen Diagnostics Co., Ltd, Room 105, Chuangxin Building, No. 199, Guoshoujing Road, Pudong District, Shanghai, 201203, China

    Peng Luo

  5. Department of Tumor Radiotherapy and Chemotherapy, Jiangxi Tumor Hospital, No. 519, Beijing East Road, Nanchang, 330029, China

    Xiao-Ming Zhong

  6. Department of Laboratory Diagnosis, Changhai Hospital Affiliated to the Second Military Medical University, No. 168, Changhai Road, Shanghai, 200433, China

    An-Mei Deng

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  1. Fei Guo
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  2. Liu Feng
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  3. Ji-Long Hu
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  4. Mei-Ling Wang
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  5. Peng Luo
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Corresponding authors

Correspondence to Xiao-Ming Zhong or An-Mei Deng.

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Fei Guo and Liu Feng contributed equally to this work.

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Guo, F., Feng, L., Hu, JL. et al. Increased PTOV1 expression is related to poor prognosis in epithelial ovarian cancer. Tumor Biol. 36, 453–458 (2015). https://doi.org/10.1007/s13277-014-2662-x

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  • DOI: https://doi.org/10.1007/s13277-014-2662-x

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