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CYP1A1 polymorphism interactions with smoking status in oral cancer risk: evidence from epidemiological studies

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Tumor Biology

Abstract

The cytochrome CYP1A1 gene has been implicated in the etiology of oral cancer. However, the results have been inconsistent. In this study, a meta-analysis was performed to clarify the associations of polymorphisms in CYP1A1 gene with oral cancer risk. Published literatures from PubMed, MEDLINE, EMBASE, and China National Knowledge infrastructure (CNKI) databases were retrieved. A total of 12 studies were included in this meta-analysis. We found that significant positive associations between CYP1A1*2A polymorphism and oral cancer risk in recessive model (CC vs. TC + TT, OR = 1.93), dominant model (CC + TC vs. TT, OR = 1.33), and additive model (CC vs. TT, OR = 1.97). In subgroup analysis based on the ethnicity of study population, significant associations were found in all three genetic models for Asians (recessive OR = 2.29, 95 % CI = 1.42–3.71; dominant OR = 1.54, 95 % CI = 1.03–2.31; additive OR = 2.39, 95 % CI = 1.47–3.88) but not non-Asians. For the smoking stratification, the result indicated a significant association between CYP1A1*2A polymorphism and oral cancer among the smoking subjects (OR = 1.83, 95 % CI = 1.47–2.26). This meta-analysis indicated a marked association of CYP1A1*2A polymorphisms with oral cancer risk, particularly among Asians, whereas there were significant interactions between the polymorphisms and cigarette smoking on oral cancer risk.

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Authors and Affiliations

  1. Department of oral and maxillofacial surgery, The 307 Hospital of the Academy of Military Medical Sciences, Beijing, 100071, People’s Republic of China

    Kai-Tao Yu, Cheng Ge, Xiao-Fang Xu, Jing-Cai Zou, Xuan Zou & Shuai Zhen

  2. Xijing Hospital, Fourth Military Medical University, Xi’an, 710032, People’s Republic of China

    Shuai Zhen

  3. Baoji Maternal and Child Health Hospital, 2 Xinjian Road East, WeiBin District, Baoji, 721000, Shanxi Province, People’s Republic of China

    Shuai Zhen

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  1. Kai-Tao Yu
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Yu, KT., Ge, C., Xu, XF. et al. CYP1A1 polymorphism interactions with smoking status in oral cancer risk: evidence from epidemiological studies. Tumor Biol. 35, 11183–11191 (2014). https://doi.org/10.1007/s13277-014-2422-y

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  • DOI: https://doi.org/10.1007/s13277-014-2422-y

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