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Aberrant promoter methylation of the SFRP1 gene may contribute to colorectal carcinogenesis: a meta-analysis

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Tumor Biology

Abstract

This meta-analysis of published cohort studies was conducted to evaluate whether promoter methylation of the secreted frizzled-related protein 1 (SFRP1) gene contributes to colorectal carcinogenesis. The Web of Science (1945 ~ 2013), the Cochrane Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013), CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013) were searched without language restrictions. Meta-analysis was conducted using the STATA 12.0 software. We calculated odds ratio (OR) and its 95 % confidence interval (95 % CI) to estimate the correlations between SFRP1 promoter methylation and colorectal carcinogenesis. In the present meta-analysis, 8 cohort studies with a total of 942 patients with colorectal cancer (CRC) were included. The pooled results revealed that the frequency of SFRP1 promoter methylation in cancer tissues were significantly higher than those of normal, adjacent, and benign tissues (cancer tissues vs. normal tissues: OR = 31.49, 95 % CI = 17.57 ~ 56.44, P < 0.001; cancer tissues vs. adjacent tissues: OR = 5.95, 95 % CI 3.12 ~ 10.00, P < 0.001; cancer tissues vs. benign tissues: OR = 3.01, 95 % CI 1.72 ~ 5.27, P < 0.001; respectively). Furthermore, ethnicity-stratified analysis indicated that SFRP1 promoter methylation was strongly correlated with colorectal carcinogenesis among both Asians and Caucasians (all P < 0.05). Our findings provide empirical evidence that SFRP1 promoter methylation may be correlated with the pathogenesis of CRC.

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References

  1. Meyer JE, Narang T, Schnoll-Sussman FH, Pochapin MB, Christos PJ, Sherr DL. Increasing incidence of rectal cancer in patients aged younger than 40 years: an analysis of the surveillance, epidemiology, and end results database. Cancer. 2010;116(18):4354–9.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Kanojia D, Garg M, Gupta S, Gupta A, Suri A. Sperm-associated antigen 9 is a novel biomarker for colorectal cancer and is involved in tumor growth and tumorigenicity. Am J Pathol. 2011;178(3):1009–20.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  3. Shen H, Yuan Y, Hu HG, Zhong X, Ye XX, Li MD, et al. Clinical significance of K-ras and BRAFmutations in Chinese colorectal cancer patients. World J Gastroenterol. 2011;17(6):809–16.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  4. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: Globocan 2008. Int J Cancer. 2010;127(12):2893–917.

    Article  CAS  PubMed  Google Scholar 

  5. Rawson JB, Manno M, Mrkonjic M, Daftary D, Dicks E, Buchanan DD, et al. Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients. Carcinogenesis. 2011;32(5):741–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Haggar FA, Boushey RP. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg. 2009;22(4):191–7.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Ogino S, Stampfer M. Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology. J Natl Cancer Inst. 2010;102(6):365–7.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Dahm CC, Keogh RH, Spencer EA, Greenwood DC, Key TJ, Fentiman IS, et al. Dietary fiber and colorectal cancer risk: a nested case-control study using food diaries. J Natl Cancer Inst. 2010;102(9):614–26.

    Article  CAS  PubMed  Google Scholar 

  9. Amatu A, Sartore-Bianchi A, Moutinho C, Belotti A, Bencardino K, Chirico G, et al. Promoter CpG island hypermethylation of the DNA repair enzyme MGMT predicts clinical response to dacarbazine in a phase II study for metastatic colorectal cancer. Clin Cancer Res. 2013;19(8):2265–72.

    Article  CAS  PubMed  Google Scholar 

  10. Huang D, Yu B, Deng Y, Sheng W, Peng Z, Qin W, et al. SFRP4 was overexpressed in colorectal carcinoma. J Cancer Res Clin Oncol. 2010;136(3):395–401.

    Article  CAS  PubMed  Google Scholar 

  11. Salehi R, Mohammadi M, Emami MH, Salehi AR. Methylation pattern of SFRP1 promoter in stool sample is a potential marker for early detection of colorectal cancer. Adv Biomed Res. 2012;1:87.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  12. Bovolenta P, Esteve P, Ruiz JM, Cisneros E, Lopez-Rios J. Beyond Wnt inhibition: new functions of secreted frizzled-related proteins in development and disease. J Cell Sci. 2008;121(Pt 6):737–46.

    Article  CAS  PubMed  Google Scholar 

  13. Veeck J, Niederacher D, An H, Klopocki E, Wiesmann F, Betz B, et al. Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. Oncogene. 2006;25(24):3479–88.

    Article  CAS  PubMed  Google Scholar 

  14. Fre S, Pallavi SK, Huyghe M, Lae M, Janssen KP, Robine S, et al. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A. 2009;106(15):6309–14.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  15. Dhir M, Montgomery EA, Glockner SC, Schuebel KE, Hooker CM, Herman JG, et al. Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. J Gastrointest Surg. 2008;12(10):1745–53.

    Article  PubMed Central  PubMed  Google Scholar 

  16. Chung MT, Lai HC, Sytwu HK, Yan MD, Shih YL, Chang CC, et al. SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol Oncol. 2009;112(3):646–53.

    Article  CAS  PubMed  Google Scholar 

  17. Garcia-Hoyos M, Cantalapiedra D, Arroyo C, Esteve P, Rodriguez J, Riveiro R, et al. Evaluation of SFRP1 as a candidate for human retinal dystrophies. Mol Vis. 2004;10:426–31.

    CAS  PubMed  Google Scholar 

  18. Curtin K, Slattery ML, Samowitz WS. CpG island methylation in colorectal cancer: past, present and future. Patholog Res Int. 2011;2011:902674.

    PubMed Central  PubMed  Google Scholar 

  19. Qi J, Zhu YQ, Luo J, Tao WH. The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor. Chin Med J. 2007;28:1954–7.

    Google Scholar 

  20. Wang W, Zhang B, Yan XJ, Wang J, Zhang N, Zhao CH. Effect of Wnt antagonist SFRP1 in the pathogenesy of colorectal cancer. Journal of China Medical University. 2012;41(5):440–3.

    CAS  Google Scholar 

  21. Shao SX, Liao XJ, Zhang YX, Qiu JM, Zhang XF, Yang GG. Multi-gene methylation detection increases positive methylation rate in colorectal cancer. Chin J Gastrointestinal Surg. 2012;15(6):629–32.

    Google Scholar 

  22. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5.

    Article  PubMed  Google Scholar 

  23. Zintzaras E, Ioannidis JP. Hegesma: Genome search meta-analysis and heterogeneity testing. Bioinformatics. 2005;21(18):3672–3.

    Article  CAS  PubMed  Google Scholar 

  24. Zintzaras E, Ioannidis JP. Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol. 2005;28(2):123–37.

    Article  PubMed  Google Scholar 

  25. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L. Comparison of two methods to detect publication bias in meta-analysis. JAMA. 2006;295(6):676–80.

    Article  CAS  PubMed  Google Scholar 

  26. Konishi K, Shen L, Wang S, Meltzer SJ, Harpaz N, Issa JP. Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias. Gastroenterology. 2007;132(4):1254–60.

    Article  CAS  PubMed  Google Scholar 

  27. Guo YL, Wang FL, Guo W, Kuang G, Yang ZB, Dong ZM. Hypermethylation of SFRP1 and DKK3 promoters in gastric cardia adenocarcinoma. Chin J Clin Exper Pathol. 2010;26(2):154–7.

    CAS  Google Scholar 

  28. Dong LJ, Gu XY, Jiang Z. Detection and significance of serum SFRP1 promoter methylation status in patients with colorectal cancer. Jiangsu Med J. 2010;36(18):2153–5.

    CAS  Google Scholar 

  29. Cheng CW, Yeh JC, Fan TP, Smith SK, Charnock-Jones DS. Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun. 2008;365(2):285–90.

    Article  CAS  PubMed  Google Scholar 

  30. Klaus A, Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer. 2008;8(5):387–98.

    Article  CAS  PubMed  Google Scholar 

  31. Ying Y, Tao Q. Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers. Epigenetics. 2009;4(5):307–12.

    Article  CAS  PubMed  Google Scholar 

  32. Jiang GX, Liu W, Cui YF, Zhong XY, Tai S, Wang ZD, et al. Reconstitution of secreted frizzled-related protein 1 suppresses tumor growth and lung metastasis in an orthotopic model of hepatocellular carcinoma. Dig Dis Sci. 2010;55(10):2838–43.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

This study was supported by the Science and Technology Research Project of Liaoning Province (no. 2011225019) and the Social Scientific Research Project of Shenyang City (no. F12-193-9-40).

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Authors and Affiliations

  1. Department of Radiotherapy, The Fourth Affiliated Hospital of China Medical University, Chongshan East No 4, Huanggu District, Liaoning, Shenyang, 110032, People’s Republic of China

    Yan-Zhi Chen, Dan Liu, Yu-Xia Zhao, He-Tong Wang, Ya Gao & Ying Chen

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  1. Yan-Zhi Chen
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  2. Dan Liu
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  3. Yu-Xia Zhao
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Correspondence to Yu-Xia Zhao.

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Chen, YZ., Liu, D., Zhao, YX. et al. Aberrant promoter methylation of the SFRP1 gene may contribute to colorectal carcinogenesis: a meta-analysis. Tumor Biol. 35, 9201–9210 (2014). https://doi.org/10.1007/s13277-014-2180-x

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  • DOI: https://doi.org/10.1007/s13277-014-2180-x

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