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An increased risk of ovarian cancer associated with polymorphism in BRCC5 gene in Caucasian populations

  • Research Article
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Tumor Biology

Abstract

Several reports on the association between the BRCC5 gene polymorphism and ovarian cancer risk have been published recently, but the estimates of the risk vary widely. We thus performed a meta-analysis in an effort to determine the association. To identify the eligible studies, we searched the PubMed, Embase, and CNKI databases, and reviewed all original studies retrieved as well as their citations. The risk of ovarian cancer was estimated using odds ratio (OR) and its 95 % confidence interval (CI). Meta-analysis of seven comparisons revealed an obvious rise in the risk of ovarian cancer under the CC vs. GG contrast model (OR = 1.52, 95 % CI = 1.07–2.16, P OR = 0.020). A similar increase was also indicated in the CC vs. GC + GG model (OR = 2.10, 95 % CI = 1.51–2.93, P OR < 0.001). Our meta-analysis indicates that the BRCC5 polymorphism may be a candidate modifier of ovarian cancer risk in Caucasians.

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Authors and Affiliations

  1. Renmin Hospital, Department of Obstetrics & Gynecology, Wuhan University, Wuhan, 430060, People’s Republic of China

    Hua Liang, Ruo-Yu Luo & Fu-Jin Shen

  2. Renmin Hospital, Department of Clinical Laboratory, Wuhan University, 99 Ziyang Rd, Wuhan, 430060, People’s Republic of China

    Yan Li

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  1. Hua Liang
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  2. Yan Li
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  4. Fu-Jin Shen
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Correspondence to Yan Li.

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Liang, H., Li, Y., Luo, RY. et al. An increased risk of ovarian cancer associated with polymorphism in BRCC5 gene in Caucasian populations. Tumor Biol. 35, 9179–9184 (2014). https://doi.org/10.1007/s13277-014-2135-2

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  • DOI: https://doi.org/10.1007/s13277-014-2135-2

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