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Interactive effect of glutathione S-transferase M1 and T1 polymorphisms on hepatocellular carcinoma

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Tumor Biology

Abstract

Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) have been involved in the risk of hepatocellular carcinoma (HCC). However, the interactive effect of GSTM1 and GSTT1 has not been reported previously. The aim of this work was to investigate the interaction and synergism of their variants. We identified nine publications including 1,085 cases and 2,396 controls containing both GSTM1 and GSTT1, and the bi-factor variance analysis of equal repeated test, binary class logistic regression analysis, meta-analysis and probability method were used in this analysis. Data showed there was no interaction between GSTM1 and GSTT1 null genotype variation in HCC development. In addition, individuals with at least one null genotype of GSTM1 and GSTT1 had higher susceptibility to HCC (OR = 2.99, 95 % CI 2.21–4.02). In the control group, the probability of individuals with at least one null genotype of GSTM1 and GSTT1 was 0.6624, while in the case group, the probability to develop HCC with at least one null genotype of GSTM1 and GSTT1 increased to 0.1760, which was considered as the changing characteristics of HCC occurrence in Chinese population. Our result suggests that there would be no direct interaction of GSTM1 and GSTT1 genotype in HCC risk. We speculate that GSTM1 and GSTT1 genotype variations have their own independent function in HCC development and may mutate independently to cause HCC. The synergism variants of the two genes in HCC development have bigger risk in Chinese population.

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References

  1. Kuper H, Tzonou A, Kaklamani E, et al. Tobacco smoking, alcohol consumption and their interaction in the causation of hepatocellular carcinoma. Int J Cancer. 2000;85:498–502.

    Article  CAS  PubMed  Google Scholar 

  2. Wang B, Huang G, Wang D, Li A, Zhipeng X. Null genotypes of GSTM1 and GSTT1 contribute to hepatocellular carcinoma risk: evidence from an updated meta-analysis. J Hepatol. 2010;53:508–18.

    Article  PubMed  Google Scholar 

  3. Schütte K, Bornschein J, Malfertheiner P. Hepatocellular carcinoma—epidemiological trends and risk factors. Dig Dis. 2009;27:80–92.

    PubMed  Google Scholar 

  4. Sun G-A, Wang L-Y, Chen C-J, et al. Genetic polymorphisms of glutathione S-transferases M1 and T1 associated with susceptibility to aflatoxin -related hepatocarcinogenesis among chronic hepatitis B carriers a nested case-control study in Taiwan. Carcinogenesis. 2001;22(8):1289–94.

    Article  CAS  PubMed  Google Scholar 

  5. Gelatti U, Covolo L, Talamini R, et al. N-Acetyltransferase-2, glutathione S-transferase M1 and T1 genetic polymorphisms, cigarette smoking and hepatocellular carcinoma: a case-control study. Int J Cancer. 2005;115:301–6.

    Article  CAS  PubMed  Google Scholar 

  6. Dong ZH, Yu SZ, Chen GC, Zhao DM, Fi YP. Relationship of GSTT1 and M1 Genotypes and their effects on elevated aflatoxin exposure and increased risk of hepatocellular carcinoma. Tumor Prev Treat Res. 1997;24(6):327–9.

    Google Scholar 

  7. Dong ZH, Zi XL, Yu SZ, Han JS. Relationship between deletion of slutathion S-transferase gene and susceptibility to primary hepatocellular carcinoma. China Public Health J. 1997;16(3):141–2.

    CAS  Google Scholar 

  8. Bian JC, Shen FM, Shen L, et al. Susceptibility to hepatocellular carcinoma associated with null genotypes of GSTM1 and GSTT1. World J Gastroenterol. 2000;6(2):228–30.

    CAS  PubMed  Google Scholar 

  9. Liu CZ, Bian JC, Jiang F, Shen FM. Genetic polymorphism of glutathione S-transferase M1, T1, P1 on susceptibility hepatocellular carcinoma. China Public Health. 2002;18(8):935–6.

    CAS  Google Scholar 

  10. Wei YP, Ma Y, Deng ZL. Genetic polymorphisms of glutathione S 2transferase M1 and T1 and the risk of hepatocellular carcinoma. Tumor. 2003;23(6):454–66.

    Google Scholar 

  11. He SJ, Tan JR, Gu YY, Zhong WG, Su SG. Genetic polymorphism analysis of GSTM1、GSTT1 in patients with hepatocellular carcinoma. J Guangxi Med Univ. 2005;22(6):875–6.

    CAS  Google Scholar 

  12. Deng ZL, Wei YP, Genetic MY. Deletion of GSTM1 and GSTT1 Detoxicated Enzymes in relation to hepatocellular carcinoma in Guangxi. Guangxi Sci. 2005;12(1):55–7.

    CAS  Google Scholar 

  13. Long XD, Ma Y, Wei YP, Deng ZL. Study on the detoxication gene gstM1-, gstT1-null and susceptibility to aflatoxin B,-related hepatocellular carcinoma in Guangxi. China J Epidemiol. 2005;26(10):777–81.

    Google Scholar 

  14. Guo HY, Bian JC, Jiang F, et al. The null genotypes of GSTM1 and GSTT1 and the genetic susceptibility of primary liver cancer in Luoyang. China Tumor. 2005;25(1):58–61.

    CAS  Google Scholar 

  15. Lei Y, Wang C-Y, Xi B, et al. GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population. World J Gastroenterol. 2011;17(27):3248–56.

    Google Scholar 

  16. Dragani TA. Risk of HCC: genetic heterogeneity and complex genetics. J Hepatol. 2010;52:252–7.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Cancer Research Institute, First Affiliated Hospital, China Medical University, Shenyang, 110001, China

    Chengguang Sui

  2. Department of Cell Biology, Key Lab of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, 110001, China

    Jianzhong Ma & Xin He

  3. Department of General Surgery, The First Affiliated Hospital, China Medical University, Shenyang, 110001, China

    Guang Wang

  4. Department of Hepatobiliary Surgery, The Tumor Hospital of Liaoning Province, Shenyang, 110042, China

    Fulu Ai

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  1. Chengguang Sui
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  2. Jianzhong Ma
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  3. Xin He
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  4. Guang Wang
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  5. Fulu Ai
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Correspondence to Jianzhong Ma.

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Sui, C., Ma, J., He, X. et al. Interactive effect of glutathione S-transferase M1 and T1 polymorphisms on hepatocellular carcinoma. Tumor Biol. 35, 8235–8241 (2014). https://doi.org/10.1007/s13277-014-2071-1

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  • DOI: https://doi.org/10.1007/s13277-014-2071-1

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