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Association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer: a meta-analysis

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Tumor Biology

Abstract

Several previous studies have investigated the association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer in various populations. However, these results remain inconsistent. Therefore, we performed this meta-analysis to evaluate the relationship between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer. An extensive literature search was performed to identify all eligible studies regarding this association. The odds ratios (ORs) with 95 % confidence intervals (CIs) were used to estimate the strength of risk under fixed and random effects models. We identified and included eight case-control studies including 2,036 cases and 2,273 controls. No significant association was found between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer under the dominant model; however, those with the SULT1A1 Arg/Arg genotype had a significantly increased risk (OR = 1.218, 95 % CI = 1.067–1.392, P = 0.0044) under the recessive model. In the subgroup analysis of ethnicity, a significant association was observed in Caucasians under the recessive model (OR = 1.269, 95 % CI = 1.069–1.506, P = 0.007). Furthermore, an increased risk of bladder cancer was observed between the Arg213His polymorphism and never smokers in the recessive model (OR = 1.428, 95 % CI = 1.079–1.890, P = 0.013). The results of this meta-analysis indicate that the SULT1A1 Arg213His polymorphism is associated with the risk bladder cancer under a recessive model; however, a possibly higher risk for Caucasians with the Arg/Arg genotype and never smokers needs further investigation.

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Acknowledgments

This study was supported by grants from the National Science Council, Taiwan (grant no.: NSC 101-2314-B-038-058) and Taipei Medical University, Taiwan (grant no.: TMU101-AE1-B40).

Conflicts of interests

None.

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Authors and Affiliations

  1. Division of General Surgery, Department of Surgery, Taipei Medical University Shuang Ho Hospital, New Taipei City, Taiwan

    Chih-Ming Su, Hsin-An Chen, Ming-Te Huang & Chih-Hsiung Wu

  2. Department of Microbiology and Immunology, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Mei-Chieh Chen

  3. Department of Ophthalmology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan

    I-Chan Lin

  4. Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Chih-Ming Su, Hsin-An Chen & Yuan-Hung Wang

  5. Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan

    Ming-Te Huang & Chih-Hsiung Wu

  6. Division of Urology, Department of Surgery, Chi-Mei Medical Center, No.901, Zhonghua Rd., Yongkang Dist., Tainan City, 710, Taiwan

    Kun-Hung Shen

  7. Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan

    Kun-Hung Shen

  8. Division of General Surgery, Department of Urology, Taipei Medical University Shuang Ho Hospital, No. 291, Jhongjheng Road, Jhonghe District, New Taipei City, 23561, Taiwan

    Yuan-Hung Wang

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  1. Chih-Ming Su
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Correspondence to Kun-Hung Shen or Yuan-Hung Wang.

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Chih-Ming Su and Mei-Chieh Chen contributed equally to this work.

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Su, CM., Chen, MC., Lin, IC. et al. Association between the SULT1A1 Arg213His polymorphism and the risk of bladder cancer: a meta-analysis. Tumor Biol. 35, 7147–7153 (2014). https://doi.org/10.1007/s13277-014-1954-5

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  • DOI: https://doi.org/10.1007/s13277-014-1954-5

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