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Rsf-1 overexpression in human prostate cancer, implication as a prognostic marker

  • Research Article
  • Published:
Tumor Biology

Abstract

Rsf-1 (HBXAP) was recently reported to be overexpressed in various cancers and associated with the malignant behavior of cancer cells. However, the expression of Rsf-1 and its clinical significance in human prostate cancer have not been reported. In the present study, we analyzed the expression pattern of Rsf-1 in human prostate cancer tissues and found that Rsf-1 was overexpressed in 45 % of prostate cancer specimens. There was a significant association between Rsf-1 overexpression and tumor stage (p = 0.0039) and preoperative PSA level (p = 0.015). Furthermore, Rsf-1 overexpression correlated with poor biomedical recurrence-free survival in prostate cancer patients (p < 0.001). Rsf-1 overexpression could serve as an independent predictor for poor recurrence-free survival (p = 0.012). In addition, small interfering RNA (siRNA) knockdown in DU145 cells with high endogenous Rsf-1 expression decrease cell proliferation, colony formation, and invasion. In conclusion, Rsf-1 is overexpressed in human prostate cancers and serves as a novel prognostic marker. Rsf-1 contributes to prostate cancer cell growth and invasion, which makes it a candidate therapeutic target.

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Acknowledgment

The study was supported by Outstanding Scientific Fund of Shengjing Hospital (No. 201205).

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Authors and Affiliations

  1. Department of Geriatrics, Shengjing Hospital of China Medical University, 36 Sanhao Road, Shenyang, 110004, China

    Hui Li, Yi Zhang, Yue Zhang, Xue Bai, Yang Peng & Ping He

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  1. Hui Li
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  2. Yi Zhang
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  3. Yue Zhang
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Correspondence to Ping He.

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Li, H., Zhang, Y., Zhang, Y. et al. Rsf-1 overexpression in human prostate cancer, implication as a prognostic marker. Tumor Biol. 35, 5771–5776 (2014). https://doi.org/10.1007/s13277-014-1766-7

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  • DOI: https://doi.org/10.1007/s13277-014-1766-7

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