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Lung cancer risk and genetic variants in East Asians: a meta-analysis

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Tumor Biology

Abstract

Inconsistent results are often found regarding the risk of genetic variants in lung cancer association studies. To alleviate these conflicts, we performed a large-scale meta-analysis to evaluate the effect of variants on lung cancer in East Asian population (Han Chinese, Japanese, and Korean). Forty-three genetic variants with data from at least three independent case-control studies were under investigation of which two variants (rs1800734 in hMLH1, rs2273953-rs1801173 bi-marker in P73) were first meta-analyzed in East Asians. We found that three variants in CYP1A1, GSTM1, and XRCC1 showed consistently significant associations with lung cancer in mixed analysis and stratified analysis, and several variants showed diverse effects interacting with different environmental factors in stratified analysis. Our study presents a comprehensive and systematic analysis of lung cancer association studies in East Asians and confirms the effect of three variants in lung cancer risk. Additionally, result from stratified analysis suggests the importance of inclusion of environmental factors, such as smoking and tumor histology, in the analysis.

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Acknowledgments

We thank Jianping Chen, Maochun Zhong, and Hua Li for the helpful discussions on this manuscript. We also thank Qiongna Xiao for the technical assistance. This work was supported by National Innovation Fund for Technology Based Firms (China, no. 09C26224422211), the Introduction of Innovative R&D Team Program of Guangdong Province (China, no. 2009010029), and Production-Education-Research Integral Program of Guangdong Province and Ministry of Education (China, no. 2011A090200114).

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Authors and Affiliations

  1. Department of Human Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA

    Qu Zhang

  2. HYK High-throughput Biotechnology Institute, 4/F, Building #11, Software Park, 2nd Central Keji Rd, Hi-Tech Industrial Park, Shenzhen, China

    Hong Jin, Lin Wang, BoBo Xin, Jie Zhang & Sitong Sheng

  3. Toy Testing Technology Center of Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen, China

    Yi Zhou

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  1. Qu Zhang
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  2. Hong Jin
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Correspondence to Qu Zhang or Sitong Sheng.

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Qu Zhang and Hong Jin contribute equally to this work.

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Zhang, Q., Jin, H., Wang, L. et al. Lung cancer risk and genetic variants in East Asians: a meta-analysis. Tumor Biol. 35, 5173–5179 (2014). https://doi.org/10.1007/s13277-014-1671-0

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  • DOI: https://doi.org/10.1007/s13277-014-1671-0

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