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Clinicopathological significance of SLP-2 overexpression in human gallbladder cancer

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Tumor Biology

Abstract

Several studies have indicated that overexpression of stomatin-like protein 2 (SLP-2) has been identified in several types of cancer. However, its role and clinical relevance in gallbladder cancer (GBC) is unknown. The purpose of this study was to reveal the prognostic significance of SLP-2 in GBC. The SLP-2 expression was examined at mRNA and protein levels by real-time quantitative polymerase chain reaction (qRT-PCR), and immunohistochemistry in GBC tissues and adjacent noncancerous tissues. Statistical analyses were applied to test the associations between SLP-2 expression, clinicopathologic factors, and prognosis. Immunohistochemistry and qRT-PCR showed that the protein and mRNA expression levels of SLP-2 were both significantly higher in GBC tissues than in adjacent noncancerous tissues. In addition, immunohistochemistry analysis showed that SLP-2 expression was significantly correlated with histological grade (P <0.001), pathologic T stage (P = 0.019), clinical stage (P = 0.001), and lymph node metastasis (P = 0.026). The Kaplan–Meier survival curves indicated that patients with high expression of SLP-2 had shorter overall survival than those with low expression (P <0.001). Meanwhile, the Cox multivariate analysis indicated that high expressions of SLP-2 were an independent prognostic factor for patients with GBC. These data showed that SLP-2 may play an important role in human GBC tumorigenesis, and SLP-2 might serve as a novel prognostic marker in human GBC.

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Authors and Affiliations

  1. Department of General Surgery, The Affiliated People’s Hospital of Jiangsu University, No. 8, Dianli Road, Zhenjiang, 212002, China

    Wei-Xin Wang, Gui Ma & Wei-Dong Qi

  2. Department of Oncology, Affiliated Jiangyin Hospital of Southeast University Medical College, No. 163, Shoushan Road, Jiangyin, 214400, China

    Qing-Feng Lin, Dong Shen, Shao-Ping Liu & Wei-Dong Mao

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  1. Wei-Xin Wang
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  2. Qing-Feng Lin
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  3. Dong Shen
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  4. Shao-Ping Liu
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  5. Wei-Dong Mao
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  6. Gui Ma
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  7. Wei-Dong Qi
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Correspondence to Qing-Feng Lin.

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Wang, WX., Lin, QF., Shen, D. et al. Clinicopathological significance of SLP-2 overexpression in human gallbladder cancer. Tumor Biol. 35, 419–423 (2014). https://doi.org/10.1007/s13277-013-1058-7

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  • DOI: https://doi.org/10.1007/s13277-013-1058-7

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